scholarly journals Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory

2014 ◽  
Vol 8 ◽  
Author(s):  
Jorge Valero ◽  
Giorgia Mastrella ◽  
Ismael Neiva ◽  
Silvia Sánchez ◽  
João O. Malva
Keyword(s):  
Spatial Memory ◽  
Adult Neurogenesis ◽  
Systemic Administration ◽  
Long Term Effects

Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner

2018 ◽  
Vol 122 ◽  
pp. 1-10 ◽  
Author(s):  
Laia Guardia-Escote ◽  
Pia Basaure ◽  
Jordi Blanco ◽  
Maria Cabré ◽  
Cristian Pérez-Fernández ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Cholinergic System ◽  
Apoe Genotype ◽  
Dependent Manner ◽  
Postnatal Exposure ◽  
Long Term Effects

Long-Term Effects of Intracerebroventricular Streptozotocin Treatment on Adult Neurogenesis in the Rat Hippocampus

2015 ◽  
Vol 12 (8) ◽  
pp. 772-784 ◽  
Author(s):  
Ping Sun ◽  
Ana Knezovic ◽  
Milena Parlak ◽  
Jacqueline Cuber ◽  
Margherita Karabeg ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Rat Hippocampus ◽  
Long Term Effects

scholarly journals Long-Term Effects of Neonatal Single or Multiple Isoflurane Exposures on Spatial Memory in Rats

2013 ◽  
Vol 4 ◽  
Author(s):  
Kathy L. Murphy ◽  
Mark G. Baxter
Keyword(s):  
Spatial Memory ◽  
Long Term Effects

Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats

2003 ◽  
Vol 145 (1-2) ◽  
pp. 171-178 ◽  
Author(s):  
W.B Rowe ◽  
J.-P O’Donnell ◽  
D Pearson ◽  
G.M Rose ◽  
M.J Meaney ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Receptor Antagonist ◽  
Memory Performance ◽  
Cognitively Impaired ◽  
Long Term Effects

Long-Term Effects of 56Fe Irradiation on Spatial Memory of Mice: Role of Sex and Apolipoprotein E Isoform

2011 ◽  
Vol 80 (2) ◽  
pp. 567-573 ◽  
Author(s):  
Laura E. Villasana ◽  
Theodore S. Benice ◽  
Jacob Raber
Keyword(s):  
Spatial Memory ◽  
Apolipoprotein E ◽  
Long Term Effects

scholarly journals Preliminary findings of single session of noninvansive brain stimulation over parietal lobe and performance on spatial memory task

2019 ◽  
Author(s):  
V Marija Čolić ◽  
Uroš Konstantinović ◽  
Jovana Bjekić ◽  
R Saša Filipović
Keyword(s):  
Spatial Memory ◽  
Parietal Cortex ◽  
Brain Stimulation ◽  
Posterior Parietal Cortex ◽  
Spatial Information ◽  
Parietal Lobe ◽  
Memory Performance ◽  
Memory Task ◽  
Long Term Effects

AbstractSpatial memory relies on efficient encoding, storage and retrieval of spatial information, which enables us to remember paths or locations of objects in everyday life. Moreover, this type of memory has been shown to decline with age and various neurodegenerative disorders. Parietal cortex has been shown to play an important role in the formation of short-term representations of spatial information. The aim of the current study was to test the possibility of immediate and long-term spatial memory enhancement, by increasing excitability of parietal posterior cortex. We used transcranial direct current stimulation (tDCS) over posterior parietal cortex in a placebo-controlled cross-over study. Participants received anodal (1.5 mA) or sham tDCS stimulation over P4 site (10-20 EEG system) for 20 minutes in two separate sessions. Immediately after stimulation, participants completed a spatial maze task, which consisted of learning block, 2D recall, and 3D recall. Spatial memory performance was tested 24 hours and 7 days after stimulation, to assess potential long-term effects. We found no significant effects of anodal stimulation on spatial memory performance either on immediate or delayed recall. This was the case with both, 2D and 3D spatial memory recall. Our results are in line with some studies that suggest that single brain stimulation sessions do not always produce effects on cognitive functions.

scholarly journals Long Term Effects of Low-Level Sarin Inhalation Exposure on the Spatial Memory of Rats in a T-Maze

2001 ◽  
Vol 44 (3) ◽  
pp. 93-96 ◽  
Author(s):  
Jiří Kassa ◽  
Marie Koupilová ◽  
Josef Vachek
Keyword(s):  
Spatial Memory ◽  
Cognitive Functions ◽  
Inhalation Exposure ◽  
Long Term Effects ◽  
Low Level ◽  
Appetitive Motivation ◽  
Low Concentrations ◽  
Level 3 ◽  
Short Time

To study the influence of low-level sarin exposure on cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber. Testing of cognitive functions was carried out using the T-maze evaluating learning and spatial memory. The behavior of sarin-exposed rats in the T-maze was tested several times within five weeks following sarin inhalation exposure to look for any cognitive impairments. The alteration of cognition was evaluated by using a method studying memory elicitation in response to appetitive motivation in a multiple T-maze. 2. Statistically significant, short-term deficiency in the T-maze performance was observed in rats exposed to symptomatic (LEVEL 3) as well as clinically asymptomatic concentration (LEVEL 2) of sarin. The repeated exposure of rats to clinically asymptomatic dose of sarin (LEVEL 2R) did not change the effect of lowlevel sarin exposure on spatial memory compared to the single exposure to the same dose of sarin. 3. Thus, sarin is able to influence the cognitive functions (e.g. spatial memory) even at low doses that do not cause clinically manifested intoxication following the inhalation exposure. Nevetheless, the alteration of spatial memory lasts for a short time only, in contrast with the severe sarin poisoning.

scholarly journals Early Stroke Induces Long-Term Impairment of Adult Neurogenesis Accompanied by Hippocampal-Mediated Cognitive Decline

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1654 ◽  
Author(s):  
Carolin Kathner-Schaffert ◽  
Lina Karapetow ◽  
Madlen Günther ◽  
Max Rudolph ◽  
Mahmoud Dahab ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Fluorescent Protein ◽  
Search Strategies ◽  
Neuronal Morphology ◽  
Aging Brain ◽  
Long Term Effects ◽  
Stroke Lesion ◽  
The Impact ◽  
Early Stroke

Stroke increases neurogenesis in the adult dentate gyrus in the short term, however, long-term effects at the cellular and functional level are poorly understood. Here we evaluated the impact of an early stroke lesion on neurogenesis and cognitive function of the aging brain. We hypothesized that a stroke disturbs dentate neurogenesis during aging correlate with impaired flexible learning. To address this issue a stroke was induced in 3-month-old C57Bl/6 mice by a middle cerebral artery occlusion (MCAO). To verify long-term changes of adult neurogenesis the thymidine analogue BrdU (5-Bromo-2′-deoxyuridine) was administrated at different time points during aging. One and half months after BrdU injections learning and memory performance were assessed with a modified version of the Morris water maze (MWM) that includes the re-learning paradigm, as well as hippocampus-dependent and -independent search strategies. After MWM performance mice were transcardially perfused. To further evaluate in detail the stroke-mediated changes on stem- and progenitor cells as well as endogenous proliferation nestin-green-fluorescent protein (GFP) mice were used. Adult nestin-GFP mice received a retroviral vector injection in the hippocampus to evaluate changes in the neuronal morphology. At an age of 20 month the nestin-GFP mice were transcardially perfused after MWM performance and BrdU application 1.5 months later. The early stroke lesion significantly decreased neurogenesis in 7.5- and 9-month-old animals and also endogenous proliferation in the latter group. Furthermore, immature doublecortin (DCX)-positive neurons were reduced in 20-month-old nestin-GFP mice after lesion. All MCAO groups showed an impaired performance in the MWM and mostly relied on hippocampal-independent search strategies. These findings indicate that an early ischemic insult leads to a dramatical decline of neurogenesis during aging that correlates with a premature development of hippocampal-dependent deficits. Our study supports the notion that an early stroke might lead to long-term cognitive deficits as observed in human patients after lesion.

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