Continuous improvements in short and long-term outcomes after partial hepatectomy for hepatocellular carcinoma in the 21st century: Single institution experience with 1300 resections over 18 years

2021 ◽  
pp. 101609
Author(s):  
Brian K.P. Goh ◽  
Darren W. Chua ◽  
Ye-Xin Koh ◽  
Ek-Khoon Tan ◽  
Juinn-Huar Kam ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Partial Hepatectomy ◽  
21St Century ◽  
Long Term Outcomes ◽  
Single Institution ◽  
Short And Long Term

scholarly journals Meta-analysis of short- and long-term outcomes after pure laparoscopic versus open liver surgery in hepatocellular carcinoma patients

2018 ◽  
Vol 33 (5) ◽  
pp. 1491-1507 ◽  
Author(s):  
Jan Witowski ◽  
Mateusz Rubinkiewicz ◽  
Magdalena Mizera ◽  
Michał Wysocki ◽  
Natalia Gajewska ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Surgery ◽  
Meta Analysis ◽  
Long Term Outcomes ◽  
Short And Long Term

Comparison of short- and long-term outcomes of patients with hepatocellular carcinoma undergoing surgical resection, local ablation, angiological treatment or palliation: Single center results over 35 years

2019 ◽  
Author(s):  
Valtteri Kairaluoma ◽  
Mira Karjalainen ◽  
Juha Saarnio ◽  
Jarmo Niemelä ◽  
Heikki Huhta ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Survival Rates ◽  
Confounding Factors ◽  
Single Center ◽  
Long Term Outcomes ◽  
Local Ablation ◽  
Short And Long Term ◽  
Overall Survival Rates

Abstract Background Hepatocellular carcinoma (HCC) is one leading cause of cancer mortality often presenting at inoperable stage. The aim of this study was to examine and compare surgically resected, locally ablated, angiologically treated and palliatively treated HCC patients’ short- and long-term outcomes in a single center over 35 year period. Methods All HCC diagnosed in Oulu University Hospital between 1983-2018 were identified from hospital records (n=273). Patients underwent hepatic resection (n=49), local ablation (RF, laser ablation or PEI; n=25), angiological treatments (TACE, TAE and SIRT; n=48) or palliative treatment (chemotherapy, best supportive care; n=151). Primary outcomes of the study were postoperative complications within 30 days after the operation, and short- (30- and 90-day) and long-term (1, 3 and 5-year) survival. Results were adjusted with sex, age, comorbidities, cirrhosis, Child-Pugh index points, ASA status, year of operation and stage. Results Surgically resected patients were younger than patients in other groups. Recurrence and local recidives occurred more often in local ablation group and in angiological treatment group (p<0.001). Surgical resection rate was 17.9%. Overall complication rates in surgical resection, local ablation and angiological group were 71.5%, 32.0% and 58.3%, (p<0.001). Major complications in respective groups occurred in 28.6%, 8.0% and 27.1%. Overall survival rates in surgical resection group were at 30 and 90 days, 1-, 3 and 5-years 95.9%, 95.9%, 85.1%, 59.0% and 51.2%. In local ablation group, respective overall survival rates were 100.0%, 100.0%, 86.1%, 43.1% and 18.8%, and in angiological group 95.8%, 93.6%, 56.1%, 26.3% and 6.6%. In cox regression model adjusted for confounding factors, local ablation and angiological treatment were significant risk factors for mortality. Prognosis was poor in palliatively treated patients. Conclusions Based on our study on Northern Finland population, the surgical resection of HCC seems to be the most effective treatment considering long-term survival and tumor recurrence after adjustment for confounding factors.

Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution

2013 ◽  
Vol 68 (5) ◽  
pp. 721-728 ◽  
Author(s):  
Yukiko Ushigome ◽  
Yoko Kano ◽  
Tadashi Ishida ◽  
Kazuhisa Hirahara ◽  
Tetsuo Shiohara
Keyword(s):  
Hypersensitivity Syndrome ◽  
Long Term Outcomes ◽  
Single Institution ◽  
Drug Induced ◽  
Short And Long Term

scholarly journals Age Is No Longer a Limit: Two Cases of Hepatectomy in Patients Over 90 Years Old

2015 ◽  
Vol 9 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Shugo Uwatoko ◽  
Kentaroh Yamamoto ◽  
Takamitsu Sasaki ◽  
Daisuke Fukumori ◽  
Hirotsune Igimi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Elderly Patients ◽  
Malignant Tumor ◽  
Poor Prognosis ◽  
Major Hepatectomy ◽  
Long Term Outcomes ◽  
Younger Patients ◽  
The World ◽  
Short And Long Term

Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. The age of patients affected by HCC is considered to be increasing, and several studies have reported significantly higher rates of morbidity and mortality after hepatectomy for HCC in elderly patients. However, other studies have reported that the short- and long-term outcomes of surgery for HCC in elderly patients are similar to those in younger patients. Whether the indications for hepatic resection in elderly patients resemble those in younger patients has thus been questioned. We describe two cases of patients over 90 years old who underwent major hepatectomy for HCC, representing the oldest patients in the world to have done so.

Short- and Long-Term Outcomes after Hepatic Resection for Hepatocellular Carcinoma with Concomitant Esophageal Varices in Patients with Cirrhosis

2008 ◽  
Vol 15 (6) ◽  
pp. 1670-1676 ◽  
Author(s):  
Yuichiro Kawano ◽  
Atsushi Sasaki ◽  
Seiichiro Kai ◽  
Yuichi Endo ◽  
Kentaro Iwaki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Resection ◽  
Esophageal Varices ◽  
Long Term Outcomes ◽  
Short And Long Term
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