Evaluating the evidence for non-monotonic dose-response relationships: A systematic literature review and (re-)analysis of in vivo toxicity data in the area of food safety

2018 ◽  
Vol 339 ◽  
pp. 10-23 ◽  
Author(s):  
C. Varret ◽  
A. Beronius ◽  
L. Bodin ◽  
B.G.H. Bokkers ◽  
P.E. Boon ◽  
...  
Keyword(s):  
Food Safety ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Dose Response ◽  
Toxicity Data ◽  
In Vivo Toxicity

Direct in vivo strain measurements in human bone—A systematic literature review

2012 ◽  
Vol 45 (1) ◽  
pp. 27-40 ◽  
Author(s):  
R. Al Nazer ◽  
J. Lanovaz ◽  
C. Kawalilak ◽  
J.D. Johnston ◽  
S. Kontulainen
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Human Bone ◽  
Strain Measurements

scholarly journals Paracetamol: not as safe as we thought? A systematic literature review of observational studies

2015 ◽  
Vol 75 (3) ◽  
pp. 552-559 ◽  
Author(s):  
Emmert Roberts ◽  
Vanessa Delgado Nunes ◽  
Sara Buckner ◽  
Susan Latchem ◽  
Margaret Constanti ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Dose Response ◽  
Observational Studies ◽  
Relative Rate ◽  
Adult Population ◽  
Assessment Development ◽  
Increased Risk ◽  
General Adult Population ◽  
Paracetamol Toxicity

ObjectivesWe conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol.MethodsWe searched Medline and Embase from database inception to 1 May 2013. We screened for observational studies in English, which reported mortality, cardiovascular, gastrointestinal (GI) or renal AEs in the general adult population at standard analgesic doses of paracetamol. Study quality was assessed using Grading of Recommendations Assessment, Development and Evaluation. Pooled or adjusted summary statistics were presented for each outcome.ResultsOf 1888 studies retrieved, 8 met inclusion criteria, and all were cohort studies. Comparing paracetamol use versus no use, of two studies reporting mortality one showed a dose–response and reported an increased relative rate of mortality from 0.95 (0.92 to 0.98) to 1.63 (1.58 to 1.68). Of four studies reporting cardiovascular AEs, all showed a dose–response with one reporting an increased risk ratio of all cardiovascular AEs from 1.19 (0.81 to 1.75) to 1.68 (1.10 to 2.57). One study reporting GI AEs reported a dose–response with increased relative rate of GI AEs or bleeds from 1.11 (1.04 to 1.18) to 1.49 (1.34 to 1.66). Of four studies reporting renal AEs, three reported a dose–response with one reporting an increasing OR of ≥30% decrease in estimated glomerular filtration rate from 1.40 (0.79 to 2.48) to 2.19 (1.4 to 3.43).DiscussionGiven the observational nature of the data, channelling bias may have had an important impact. However, the dose–response seen for most endpoints suggests a considerable degree of paracetamol toxicity especially at the upper end of standard analgesic doses.

Do in vivo kinematic studies provide insight into adjacent segment degeneration? A qualitative systematic literature review

2015 ◽  
Vol 24 (9) ◽  
pp. 1865-1881 ◽  
Author(s):  
Masoud Malakoutian ◽  
David Volkheimer ◽  
John Street ◽  
Marcel F. Dvorak ◽  
Hans-Joachim Wilke ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Adjacent Segment Degeneration ◽  
Adjacent Segment ◽  
Kinematic Studies ◽  
Insight Into

Quantitative in vivo longitudinal nerve excursion and strain in response to joint movement: A systematic literature review

2014 ◽  
Vol 29 (8) ◽  
pp. 839-847 ◽  
Author(s):  
Ana Silva ◽  
André Manso ◽  
Ricardo Andrade ◽  
Vanessa Domingues ◽  
Maria Piedade Brandão ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Joint Movement ◽  
Longitudinal Nerve

scholarly journals The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

2010 ◽  
Vol 118 (2) ◽  
pp. 470-484 ◽  
Author(s):  
Jochem Louisse ◽  
Esther de Jong ◽  
Johannes J. M. van de Sandt ◽  
Bas J. Blaauboer ◽  
Ruud A. Woutersen ◽  
...  
Keyword(s):  
Kinetic Modeling ◽  
Dose Response ◽  
Developmental Toxicity ◽  
In Vitro Toxicity ◽  
Toxicity Data ◽  
Glycol Ethers ◽  
Response Curves ◽  
Physiologically Based

scholarly journals Association between fish consumption and risk of dementia: a new study from China and a systematic literature review and meta-analysis

2018 ◽  
Vol 21 (10) ◽  
pp. 1921-1932 ◽  
Author(s):  
Aishat T Bakre ◽  
Ruoling Chen ◽  
Ranjit Khutan ◽  
Li Wei ◽  
Tina Smith ◽  
...  
Keyword(s):  
Rural Communities ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Dose Response ◽  
Fish Consumption ◽  
Meta Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Cross Sectional ◽  
The Impact

AbstractObjectiveTo assess the association of fish consumption with risk of dementia and its dose–response relationship, and investigate variations in the association among low-, middle- and high-income countries.DesignA new community-based cross-sectional study and a systematic literature review.SettingsUrban and rural communities in China; population-based studies systematically searched from worldwide literature.SubjectsChinese adults aged ≥60 years in six provinces (n 6981) took part in a household health survey of dementia prevalence and risk factors. In addition, 33 964 participants from eleven published and eligible studies were included in the systematic review and meta-analysis.ResultsIn the new study in China, 326 participants were diagnosed with dementia (4·7 %); those who consumed any amount of fish in the past two years v. those who consumed no fish had reduced risk of dementia (adjusted OR=0·73, 95 % CI 0·64, 0·99), but the dose–response relationship was not statistically significant. The meta-analysis of available data from the literature and the new study showed relative risk (RR) of dementia of 0·80 (95 % CI 0·74, 0·87) for people with fish consumption; the impact was similar among countries with different levels of income. Pooled dose–response data revealed RR (95 % CI) of 0·84 (0·72, 0·98), 0·78 (0·68, 0·90) and 0·77 (0·61, 0·98) in people with low, middle and high consumption of fish, respectively. Corresponding figures for Alzheimer’s disease were 0·88 (0·74, 1·04), 0·79 (0·65, 0·96) and 0·67 (0·58, 0·78), respectively.ConclusionsGreater consumption of fish is associated with a lower risk of dementia. Increasing fish consumption may help prevent dementia worldwide regardless of income level.

Alcohol, alcoholic beverages, and melanoma risk: a systematic literature review and dose–response meta-analysis

2018 ◽  
Vol 57 (7) ◽  
pp. 2323-2332 ◽  
Author(s):  
Sara Gandini ◽  
Giovanna Masala ◽  
Domenico Palli ◽  
Benedetta Cavicchi ◽  
Calogero Saieva ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Dose Response ◽  
Meta Analysis ◽  
Alcoholic Beverages ◽  
Melanoma Risk

scholarly journals Engaging Marginalized, “At-Risk” Middle-Level Students: A Focus on the Importance of a Sense of Belonging at School

2018 ◽  
Vol 8 (3) ◽  
pp. 138 ◽  
Author(s):  
Donna Pendergast ◽  
Jeanne Allen ◽  
Glenda McGregor ◽  
Michelle Ronksley-Pavia
Keyword(s):  
At Risk ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Sense Of Belonging ◽  
Middle Level ◽  
Pedagogical Practices ◽  
Marginalized Students ◽  
Data Set ◽  
Rich Data

The philosophy of middle level education is to intentionally create a learning environment that supports every young adolescent. The literature around engagement points to the need for students to experience (among other requirements) a sense of belonging at school (SOBAS). When the need for belonging is not achieved there may be significant consequences, including an impact on intellectual performance, and hence, learning potential may not be achieved. For students with marginalized identities, an intensification of factors that create challenges places them at-risk of disengaging and their sense of belonging at school is more likely to be compromised. Nurturing SOBAS is positively associated with the retention of students who are at-risk of dropping out of, thereby being an aspirational goal of education. Methods: The findings of a systematic literature review related to young adolescents and the importance of SOBAS forms a focused literature base. We highlight findings from a study that explored the effectiveness of engagement strategies for marginalized students in one educational jurisdiction in Australia. Data in the form of a series of interviews and focus groups conducted with 25 students, 25 of their teachers, and 39 school leaders provides a rich data set for thematic content analysis. Inductive analysis and in vivo coding led to a framework that summarized each of the sub-group data sets to convey emergent themes. Results: Five themes related to SOBAS emerged from the data: (a) Relationships in School; (b) School Climate; (c) Pedagogical Practices; (d) Specific Programs and Activities; and (e) Other Issues, mainly variables such as family, mental health, trauma and poverty that impacted on a student’s SOBAS. Conclusion: The systematic literature review and the findings of the empirical study presented in this paper highlight aspects of SOBAS that can be formalized into a series of strategies to increase retention of marginalized students.

Sign in / Sign up

Export Citation Format

Share Document