Toxicity and cardiac effects of acute exposure to tryptophan metabolites on the kynurenine pathway in early developing zebrafish (Danio rerio) embryos

2018 ◽  
Vol 341 ◽  
pp. 16-29 ◽  
Author(s):  
Michal Majewski ◽  
Natalia Kasica ◽  
Anna Jakimiuk ◽  
Piotr Podlasz
Keyword(s):  
Danio Rerio ◽  
Kynurenine Pathway ◽  
Acute Exposure ◽  
Cardiac Effects ◽  
Tryptophan Metabolites ◽  
Danio Rerio Embryos

Neurulation in the posterior region of zebrafish, Danio rerio embryos

2021 ◽  
Author(s):  
Julia Gladysheva ◽  
Evdokia Evnukova ◽  
Ekaterina Kondakova ◽  
Milana Kulakova ◽  
Vladimir Efremov
Keyword(s):  
Danio Rerio ◽  
Posterior Region ◽  
Danio Rerio Embryos

scholarly journals Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos

Chemosphere ◽  
2021 ◽  
Vol 276 ◽  
pp. 130282
Author(s):  
Johannes Pohl ◽  
Oksana Golovko ◽  
Gunnar Carlsson ◽  
Stefan Örn ◽  
Monika Schmitz ◽  
...  
Keyword(s):  
Network Analysis ◽  
Danio Rerio ◽  
Danio Rerio Embryos

91. Studies on impact of chilling on sox gene expression in zebrafish (Danio rerio) embryos

Cryobiology ◽  
2010 ◽  
Vol 61 (3) ◽  
pp. 389
Author(s):  
K.K. Desai ◽  
E. Spikings ◽  
D.M. Rawson ◽  
T. Zhang
Keyword(s):  
Gene Expression ◽  
Danio Rerio ◽  
Sox Gene ◽  
Danio Rerio Embryos

Short exposure to glyphosate induces locomotor, craniofacial, and bone disorders in zebrafish (Danio rerio) embryos

2021 ◽  
pp. 103700
Author(s):  
Rubén D. Díaz-Martín ◽  
Ana Carvajal-Peraza ◽  
Beatriz Yáñez-Rivera ◽  
Miguel Betancourt-Lozano
Keyword(s):  
Danio Rerio ◽  
Short Exposure ◽  
Bone Disorders ◽  
Danio Rerio Embryos

Effects of the brominated flame retardant, TBCO, on development of zebrafish (Danio rerio) embryos

Chemosphere ◽  
2021 ◽  
Vol 266 ◽  
pp. 129195
Author(s):  
Darren Van Essen ◽  
Chloe Devoy ◽  
Justin Miller ◽  
Paul D. Jones ◽  
Steve Wiseman
Keyword(s):  
Flame Retardant ◽  
Danio Rerio ◽  
Brominated Flame Retardant ◽  
Danio Rerio Embryos

Simvastatin effects on detoxification mechanisms in Danio rerio embryos

2016 ◽  
Vol 23 (11) ◽  
pp. 10615-10629 ◽  
Author(s):  
V. Cunha ◽  
M. M. Santos ◽  
P. Moradas-Ferreira ◽  
M. Ferreira
Keyword(s):  
Danio Rerio ◽  
Detoxification Mechanisms ◽  
Danio Rerio Embryos

scholarly journals Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis

2013 ◽  
Vol 6s1 ◽  
pp. IJTR.S11737 ◽  
Author(s):  
Richard O. Williams
Keyword(s):  
Rheumatoid Arthritis ◽  
Anthranilic Acid ◽  
Kynurenine Pathway ◽  
Gene Encoding ◽  
Rate Limiting Step ◽  
Tryptophan Metabolites ◽  
Synthetic Derivative ◽  
Rate Limiting ◽  
Kinetics Of ◽  
Draining Lymph Nodes

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting step along the kynurenine pathway and is thought to play a key role in immune homeostasis through depletion of tryptophan and accumulation of kynurenines. In this review we summarize recent research into the possibility of harnessing the IDO pathway for the therapy of rheumatoid arthritis. Inhibition of IDO activity, or knockout of the gene encoding IDO, was shown to cause an increase in the severity of collagen-induced arthritis, an animal model of rheumatoid arthritis. The increased severity of disease was associated with elevated numbers of pathogenic Th1 and Th17 cells in the joints and draining lymph nodes. In another study, analysis of the kinetics of expression of downstream kynurenine pathway enzymes during the course of arthritis revealed a potential role for tryptophan metabolites in resolution of arthritis. Furthermore, the therapeutic administration of L-kynurenine or [3,4-dimethoxycinnamonyl]-anthranilic acid (a synthetic derivative of 3-hydroxy-anthranilic acid) significantly reduced both clinical and histological progression of experimental arthritis. These findings raise the possibility of exploiting the IDO pathway for the therapy of autoimmune disease.

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