scholarly journals PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation

2018 ◽  
Vol 356 ◽  
pp. 151-158 ◽  
Author(s):  
Ognian C. Ikonomov ◽  
George Altankov ◽  
Diego Sbrissa ◽  
Assia Shisheva
Keyword(s):  
Cytoplasmic Vacuolation

Ultrastructural diagnosis of plasmacytoma on a fine-needle aspirate

1991 ◽  
Vol 49 ◽  
pp. 102-103
Author(s):  
S. Siew ◽  
W. deMendonca-Calaca
Keyword(s):  
Mononuclear Cells ◽  
Fibrous Tissue ◽  
Needle Aspiration ◽  
Focal Lesions ◽  
Diffuse Infiltration ◽  
Fine Needle ◽  
Cytoplasmic Vacuolation ◽  
Chest Mass ◽  
Mitotic Figures ◽  
Microscopy Examination

A 36 year old man presented with a mass in the chest and multiple “hot” focal lesions were identified on bone scan. Fine needle aspiration was performed of the chest mass. Routine histology showed the presence of some bundles of dense fibrous tissue and a diffuse infiltration of mononuclear cells, which varied in size and nucleo-cytoplasmic ratio. The smaller cells had eccentric hyperchromatic nuclei. Nucleoli were noted in the larger cells. There was well marked cytoplasmic vacuolation of some of the cells. Mitosis was present. A small fragment of tissue was received for electron microscopy. Examination of 1 μm sections showed trabeculae of medium-large polygonal cells with eccentric nuclei and occasional nucleoli. Some irregularly shaped cells had well marked cytoplasmic vacuolation. Mitotic figures were present.

Epithelioid haemangioendothelioma in the parapharyngeal space

2006 ◽  
Vol 120 (6) ◽  
pp. 505-507 ◽  
Author(s):  
J-C Lee ◽  
B-J Lee ◽  
S-G Wang ◽  
H-W Kim
Keyword(s):  
Endothelial Cells ◽  
Facial Nerve ◽  
Head And Neck ◽  
Soft Tissues ◽  
Parapharyngeal Space ◽  
Malignant Potential ◽  
Vascular Neoplasm ◽  
Cytoplasmic Vacuolation ◽  
Upper And Lower Extremities ◽  
Epithelioid Haemangioendothelioma

Epithelioid haemangioendothelioma (EHE) is an uncommon vascular neoplasm which occurs rarely in the head and neck and has an unpredictable clinical behaviour. It is characterized by round or spindle-shaped endothelial cells with cytoplasmic vacuolation. Most often, EHE arises from the soft tissues of the upper and lower extremities, and it has borderline malignant potential. We describe the first reported case of EHE in the parapharyngeal space, which was treated successfully via a transcervical–transparotid approach (following angiography with embolization), without massive intra-operative bleeding or facial nerve damage.

Morphology of Nicotiana tabacum cells grown in contact with lunar material

1973 ◽  
Vol 51 (1) ◽  
pp. 151-156 ◽  
Author(s):  
P. S. Baur ◽  
C. H. Walkinshaw ◽  
R. S. Halliwell ◽  
V. E. Scholes
Keyword(s):  
Nicotiana Tabacum ◽  
Tissue Cultures ◽  
Chloroplast Structure ◽  
Cytoplasmic Vacuolation ◽  
Lunar Material ◽  
Cell Association

Suspension and stationary habituated tobacco tissue cultures were examined histologically and cytologically after treatment with 0.22 g of lunar material. The treated and untreated tissues differed in chloroplast structure and distribution, degree of cell association, cytoplasmic vacuolation and vesiculation, and living to nonliving ratios.

Swelling and cytoplasmic vacuolation

1946 ◽  
Vol 42 (0) ◽  
pp. B253-B254
Author(s):  
E. Fauré-Fremiet
Keyword(s):  
Cytoplasmic Vacuolation

Cytoplasmic vacuolation, intracytoplasmic lumina, and DPAS staining in ductal carcinoma of the breast

2003 ◽  
Vol 28 (6) ◽  
pp. 291-294 ◽  
Author(s):  
Raje Nijhawan ◽  
Arvind Rajwanshi ◽  
Upasana Gautam ◽  
Subhash K. Gupta
Keyword(s):  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Cytoplasmic Vacuolation ◽  
Intracytoplasmic Lumina

scholarly journals Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4682
Author(s):  
Recardia Schoeman ◽  
Natasha Beukes ◽  
Carminita Frost
Keyword(s):  
Breast Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Effect Analysis ◽  
Cytoplasmic Vacuolation ◽  
Cycle Arrest ◽  
Median Effect Analysis ◽  
Mcf 7

This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across the MDA-MB-231 and MCF-7 human breast cancer cell lines. Cannabinoids were combined and their synergistic interactions were evaluated using median effect analysis. The most promising cannabinoid combination (C6) consisted of tetrahydrocannabinol, cannabigerol (CBG), cannabinol (CBN), and cannabidiol (CBD), and displayed favorable dose reduction indices and limited cytotoxicity against the non-cancerous breast cell line, MCF-10A. C6 exerted its effects in the MCF-7 cell line by inducing cell cycle arrest in the G2 phase, followed by the induction of apoptosis. Morphological observations indicated the induction of cytoplasmic vacuolation, with further investigation suggesting that the vacuole membrane was derived from the endoplasmic reticulum. In addition, lipid accumulation, increased lysosome size, and significant increases in the endoplasmic reticulum chaperone protein glucose-regulated protein 78 (GRP78) expression were also observed. The selectivity and ability of cannabinoids to halt cancer cell proliferation via pathways resembling apoptosis, autophagy, and paraptosis shows promise for cannabinoid use in standardized breast cancer treatment.

scholarly journals Effects of Tamiflu and Adamine on histology and ultrastructure of the liver of albino mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nagla Zaky Ibrahim El-Alfy ◽  
Samia Mohamed Sakr ◽  
Mahmoud Fathy Mahmoud ◽  
Heba Ahmed Omar
Keyword(s):  
Microscopic Investigation ◽  
Electron Microscopic Investigation ◽  
Hepatic Tissue ◽  
Hepatic Veins ◽  
Endothelial Lining ◽  
Electron Microscopic ◽  
Hepatic Sinusoid ◽  
Cytoplasmic Vacuolation ◽  
Prevention And Treatment ◽  
Albino Mice

Abstract Background Tamiflu (Oseltamivir) and Adamine (Amantadine HCl) are antiviral drugs which are used for prevention and treatment for influenza. The present study was carried out to evaluate the effect of Tamiflu and Adamine on the liver of adult male albino mice from the histological and ultrastructural points of views. Results Histological examination of liver sections treated with Tamiflu and Adamine included enlargement and congestion of central and hepatic veins in addition to erosion of their endothelial lining cells, cytoplasmic vacuolation of hepatocytes, pyknosis of their nuclei, and dilatation of hepatic sinusoid. The electron microscopic investigation illustrated mitochondrial swelling, fragmented rough endoplasmic reticulum, cytoplasmic vacuolation, the nuclei with irregular envelope and condensed heterochromatin, dilated microvilli in sinusoid, in addition to active Kupffer cells have many lysosomes and filopodia in its membrane. Conclusion The study suggested that both drugs induced histopathological and ultrastructural alterations in hepatic tissue. In conclusion, Tamiflu and Adamine have pathological effects on liver of albino mice (Mus musculus).

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