The dumbbell probe mediated triple cascade signal amplification strategy for sensitive and specific detection of uracil DNA glycosylase activity

Talanta ◽  
2021 ◽  
pp. 122680
Author(s):  
Yayun Yang ◽  
Xiaoting Liu ◽  
Nan Zhang ◽  
Wei Jiang
Keyword(s):  
Signal Amplification ◽  
Dna Glycosylase ◽  
Specific Detection ◽  
Uracil Dna Glycosylase ◽  
Amplification Strategy

A novel fluorescent assay for uracil DNA glycosylase activity built on the 3′–5′ exonuclease activity-based endonuclease IV cyclic signal amplification strategy

2020 ◽  
Vol 44 (48) ◽  
pp. 21211-21217
Author(s):  
Jing-Xuan Tian ◽  
Yan-Zhao Fang ◽  
Yi-Xuan Yang ◽  
Shuang Wu ◽  
Qiang Xiao ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Dna Glycosylase ◽  
Exonuclease Activity ◽  
Sensitive Assay ◽  
Fluorescent Assay ◽  
Uracil Dna Glycosylase ◽  
Highly Sensitive ◽  
Dna Strands ◽  
Amplification Strategy

The unique 3′-5′ exonuclease activity of endonuclease IV to DNA strands has been demonstrated, which enables the development of a novel highly sensitive assay for UDG activity.

Ligase chain reaction-based electrochemical biosensor for the ultrasensitive and specific detection of single nucleotide polymorphisms

2019 ◽  
Vol 43 (36) ◽  
pp. 14327-14335 ◽  
Author(s):  
Wancun Zhang ◽  
Fang Hu ◽  
Xianwei Zhang ◽  
Wei Meng ◽  
Yaodong Zhang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Signal Amplification ◽  
Electrochemical Biosensor ◽  
Nucleotide Polymorphisms ◽  
Specific Detection ◽  
Chain Reaction ◽  
Single Nucleotide ◽  
Ligase Chain Reaction ◽  
Amplification Strategy

In this study, a sensitive electrochemical biosensor for universally, robustly, specifically, and sensitively detecting SNPs was developed by using LCR as a signal amplification strategy.

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