G Protein–Coupled Receptor Kinases in Cardiovascular Disease: Why “Where” Matters

2012 ◽  
Vol 22 (8) ◽  
pp. 213-219 ◽  
Author(s):  
Fadia A. Kamal ◽  
Joshua G. Travers ◽  
Burns C. Blaxall
Keyword(s):  
Cardiovascular Disease ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease

2006 ◽  
Vol 69 (1) ◽  
pp. 46-56 ◽  
Author(s):  
P PENELA ◽  
C MURGA ◽  
C RIBAS ◽  
A TUTOR ◽  
S PEREGRIN ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 75
Author(s):  
Marta Laganà ◽  
Géraldine Schlecht-Louf ◽  
Françoise Bachelerie
Keyword(s):  
G Protein ◽  
Chemokine Receptor ◽  
Immune Cell ◽  
Neutrophil Migration ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Immune Cell Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Gpcr Desensitization

Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.

Correlation Between Beta-Adrenoceptors and G-Protein-Coupled Receptor Kinases in Pretransplantation Heart Failure

2008 ◽  
Vol 40 (9) ◽  
pp. 3014-3016 ◽  
Author(s):  
J. Agüero ◽  
L. Almenar ◽  
P. D'Ocon ◽  
E. Oliver ◽  
F. Montó ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Beta Adrenoceptors ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

2000 ◽  
Vol 86 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Andrea D. Eckhart ◽  
Sandra J. Duncan ◽  
Raymond B. Penn ◽  
Jeffrey L. Benovic ◽  
Robert J. Lefkowitz ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled
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