A new bioorthogonal cross-linker with alkyne and hydrazide end groups for chemoselective ligation. Application to antibody labelling

Tetrahedron ◽  
2012 ◽  
Vol 68 (47) ◽  
pp. 9638-9644 ◽  
Author(s):  
Nathalie Fischer-Durand ◽  
Michèle Salmain ◽  
Anne Vessières ◽  
Gérard Jaouen
Keyword(s):  
Chemoselective Ligation ◽  
End Groups ◽  
Cross Linker ◽  
Antibody Labelling

scholarly journals Glycoconjugate synthesis using chemoselective ligation

2019 ◽  
Vol 17 (10) ◽  
pp. 2646-2650 ◽  
Author(s):  
Shuihong Cheng ◽  
Paeton L. Wantuch ◽  
Megan E. Kizer ◽  
Dustin R. Middleton ◽  
Ruitong Wang ◽  
...  
Keyword(s):  
Adipic Acid ◽  
Chemoselective Ligation ◽  
Cross Linker

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker.

Photoyellowing behavior of non-phenolic lignin models representative of end groups and β-ether structures

2004 ◽  
Vol 19 (2) ◽  
pp. 146-154
Author(s):  
Jim Parkås ◽  
Magnus Paulsson ◽  
Shiming Li ◽  
Knut Lundquist ◽  
Ulla Westermark
Keyword(s):  
End Groups

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins

2020 ◽  
Vol 17 (2) ◽  
pp. 85-89
Author(s):  
Francisco J. Hidalgo ◽  
Nathan A.P. Lorentz ◽  
TinTin B. Luu ◽  
Jonathan D. Tran ◽  
Praveen D. Wickremasinghe ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Dynamic Behavior ◽  
Industrial Applications ◽  
19F Nmr ◽  
Nmr Studies ◽  
Synthetic Pathway ◽  
End Groups ◽  
Sugar End

: Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.

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