New efficient synthesis of 1H-pyrimido[2,1-b]quinazoline-2,6-diones via a tandem aza-Wittig/nucleophilic addition/intramolecular cyclization/isomerization reaction starting from the Baylis–Hillman adducts

Tetrahedron ◽  
2015 ◽  
Vol 71 (3) ◽  
pp. 419-423 ◽  
Author(s):  
Ding Yuan ◽  
Han-Han Kong ◽  
Ming-Wu Ding
Keyword(s):  
Intramolecular Cyclization ◽  
Nucleophilic Addition ◽  
Isomerization Reaction ◽  
Efficient Synthesis

CF3SOCl-Promoted Intramolecular Cyclization of β-Diketones: An Efficient Synthesis of Flavones

Tetrahedron ◽  
2021 ◽  
pp. 132226
Author(s):  
Dong-Wei Sun ◽  
Yong-Yan Zhou ◽  
Min Jiang ◽  
Tang Nian ◽  
Jin-Tao Liu
Keyword(s):  
Intramolecular Cyclization ◽  
Efficient Synthesis

scholarly journals Isolation of a post-PKS C–C branching jadomycin from S. venezuelae ISP5230 in the presence of 8-aminooctanoic acid

2018 ◽  
Vol 96 (7) ◽  
pp. 760-764 ◽  
Author(s):  
Jeanna M. MacLeod ◽  
Stephanie M. Forget ◽  
Camilo F. Martinez-Farina ◽  
David L. Jakeman
Keyword(s):  
Natural Products ◽  
Amino Acid ◽  
Natural Product ◽  
Intramolecular Cyclization ◽  
Nucleophilic Addition ◽  
Culture Method ◽  
Amino Acid Supplementation ◽  
Acid Supplementation

The jadomycin family of natural products was first identified and characterized by Vining and co-workers at Dalhousie University in the 1990s. Herein, we report findings from a recently developed co-amino acid supplementation culture method with S. venezuelae ISP5230 using 8-aminooctanoic acid, where the major natural product was a jadomycin variant omitting an E-ring (1). These results reinforce that the 3a position is susceptible to nucleophilic addition by cellular metabolites in jadomycin biosynthesis when intramolecular cyclization is unfavorable. Further, the cytotoxicity data for several unsubstituted E-ring jadomycins are reported and discussed.

ChemInform Abstract: Efficient Synthesis of 2,8-Diazabicyclo(4.3.0)nonane Derivatives via Intramolecular Cyclization Reaction.

ChemInform ◽  
2010 ◽  
Vol 27 (7) ◽  
pp. no-no
Author(s):  
J. W. LEE ◽  
H. J. SON ◽  
J. H. LEE ◽  
Y. E. JUNG ◽  
G. J. YOON ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Cyclization Reaction ◽  
Efficient Synthesis

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

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