Isolation of a post-PKS C–C branching jadomycin from S. venezuelae ISP5230 in the presence of 8-aminooctanoic acid
2018 ◽
Vol 96
(7)
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pp. 760-764
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Keyword(s):
The jadomycin family of natural products was first identified and characterized by Vining and co-workers at Dalhousie University in the 1990s. Herein, we report findings from a recently developed co-amino acid supplementation culture method with S. venezuelae ISP5230 using 8-aminooctanoic acid, where the major natural product was a jadomycin variant omitting an E-ring (1). These results reinforce that the 3a position is susceptible to nucleophilic addition by cellular metabolites in jadomycin biosynthesis when intramolecular cyclization is unfavorable. Further, the cytotoxicity data for several unsubstituted E-ring jadomycins are reported and discussed.
2009 ◽
Vol 103
(6)
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pp. 1176-1191
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Keyword(s):
1992 ◽
Vol 24
(Supplement)
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pp. S150
Keyword(s):
2009 ◽
Vol 87
(4)
◽
pp. 1270-1281
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