Tissue engineering solutions to replace contractile function during pediatric heart surgery

2020 ◽  
Vol 67 ◽  
pp. 101452
Author(s):  
Stuart K. Williams ◽  
Ravi K. Birla
Circulation ◽  
1996 ◽  
Vol 94 (5) ◽  
pp. 1063-1067 ◽  
Author(s):  
Robert E. Shaddy ◽  
Dixie D. Hunter ◽  
Karen A. Osborn ◽  
Linda M. Lambert ◽  
L. LuAnn Minich ◽  
...  

Circulation ◽  
2000 ◽  
Vol 102 (Supplement 3) ◽  
pp. III-179-III-182 ◽  
Author(s):  
J. P. Breinholt ◽  
J. A. Hawkins ◽  
L. M. Lambert ◽  
T. C. Fuller ◽  
T. Profaizer ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Yifei Li ◽  
Donghui Zhang

During the past several decades, major advances and improvements now promote better treatment options for cardiovascular diseases. However, these diseases still remain the single leading cause of death worldwide. The rapid development of cardiac tissue engineering has provided the opportunity to potentially restore the contractile function and retain the pumping feature of injured hearts. This conception of cardiac tissue engineering can enable researchers to produce autologous and functional biomaterials which represents a promising technique to benefit patients with cardiovascular diseases. Such an approach will ultimately reshape existing heart transplantation protocols. Notable efforts are accelerating the development of cardiac tissue engineering, particularly to create larger tissue with enhanced functionality. Decellularized scaffolds, polymer synthetics fibrous matrix, and natural materials are used to build robust cardiac tissue scaffolds to imitate the morphological and physiological patterns of natural tissue. This ultimately helps cells to implant properly to obtain endogenous biological capacity. However, newer designs such as the hydrogel scaffold-free matrix can increase the applicability of artificial tissue to engineering strategies. In this review, we summarize all the methods to produce artificial cardiac tissue using scaffold and scaffold-free technology, their advantages and disadvantages, and their relevance to clinical practice.


1996 ◽  
Vol 22 (5) ◽  
pp. 492-494 ◽  
Author(s):  
C. Bartels ◽  
B. Hadzik ◽  
M. Abel ◽  
B. Roth

2017 ◽  
Vol 69 (11) ◽  
pp. 591
Author(s):  
Meena Nathan ◽  
Brielle Tishler ◽  
Kimberlee Gauvreau ◽  
Gregory S. Matte ◽  
Robert J. Howe ◽  
...  

2018 ◽  
Vol 30 (1) ◽  
pp. 62-68
Author(s):  
Punkaj Gupta ◽  
Mallikarjuna Rettiganti ◽  
Andrew Wilcox ◽  
Mai-Anh Vuong-Dac ◽  
Jeffrey M. Gossett ◽  
...  

2018 ◽  
Vol 29 (2) ◽  
pp. 195-199 ◽  
Author(s):  
Kathleen N. Fenton ◽  
Frank Molloy ◽  
William M. Novick

AbstractBackgroundIt has become increasingly apparent that only the truly effective humanitarian work emphasises empowering local practitioners. One problem, though, is that we are often seen as the “experts” who have come to “save” the children. This perception may adversely affect the confidence in the country’s own providers.MethodsNon-profit organisations performing paediatric heart surgery in developing countries were identified from two sources: the CTSnet “volunteerism” web page and an Internet search using the term “Pediatric Heart Surgery Medical Mission.” The website of each organisation was reviewed, seeking a “purpose” or “mission” statement or summary of the organisation’s work. A separate Internet search of news articles was performed. The top five articles were analysed for each organisation, and the findings are then analysed using the Principlist and Utilitarian ethical systems.ResultsA total of 10 separate non-profit organisations were identified. The websites of eight (80%) placed significant emphasis on the educational aspects of their work and/or on interaction with local professionals. However, of 43 news articles reviewed, reporters mentioned education of, or interaction with, local professionals in only 14 (33%), and four out of 10 organisations studied had no mention of the local providers in any article.ConclusionsAlthough non-profit organisations emphasise the teaching and programme-building aspects of their efforts, media reports largely focus on simpler and more emotional stories such as patient successes or large donations. Acknowledgement of the clinical and financial contributions of the host countries is both a duty following from the principle of justice and an important factor in long-term programme building.


Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 141
Author(s):  
Christiane Neuhof ◽  
Friedhelm Dapper ◽  
Olaf Walter ◽  
Jürgen Bauer ◽  
Edwin Fink ◽  
...  

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