Mouse models of osteoarthritis provide new research tools

2005 ◽  
Vol 26 (7) ◽  
pp. 333-335 ◽  
Author(s):  
M YOUNG
Author(s):  
Tetiana Bondaruk

Іntroduction. Historical and legal science, as well as the science of law in general, is acutely faced with challenges related to the new stage of development of humanities knowledge and the corresponding change of research paradigm that occurs during the struggle between classical and nonclassical (postclassical) types of legal understanding Тhe aim of the article. Тhese processes need to be understood and "adapted" in particular in the historical and legal discourse. In particular, it is proposed to analyze the phenomenon of deformation of the phenomenon of law, and the resulting differentiation of the subject, in particular in historical and legal research, and the coherence of research tools offered within the classical and nonclassical types of legal understanding Results. Modern methodological research is a natural reaction of the domestic legal process to the dominance of the monistic materialist approach to the study of legal phenomena, which actualizes anthropological and axiological approaches. Both anthropologization and axiologization of law cause the deformalization of the phenomenon of law, creating a conceptual In the light of the above, it seems important to consider in relation to the relationship such concepts as legal reality (historical and legal reality), legal life, legal system as central, and legal space, legal field, legal environment as peripheral. At the same time, attention is drawn to the normative nature of the legal system, the ontological nature of legal reality, the inconsistency of legal life as a starting point in the choice of methodological tools. Introduction to the historical and legal discourse of «ontological metaphors»: legal communication, legal event, legal life, legal space, legal field, legal environment, etc., will activate the intersubjective model of knowledge of law as a sociocultural phenomenon, draw attention to the dynamics of law, using an arsenal of non-classical methodology. Conclusions. An overview of some trends that lead to a change in the object and subject of jurisprudence shows a radical change in its methodology, which should form research tools to answer new research questions. This process is part of the process of modern «cultivation» of integrated thinking as opposed to or in addition to analytical and systemic, which is characterized by consideration of reality in mechanistic categories, and, being irreversible, requires appropriate historical and legal reflections


2020 ◽  
Vol 21 (3) ◽  
pp. 1122 ◽  
Author(s):  
Michal Burmistrz ◽  
Kamil Krakowski ◽  
Agata Krawczyk-Balska

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)–CRISPR-associated (Cas) systems have revolutionized modern molecular biology. Numerous types of these systems have been discovered to date. Many CRISPR–Cas systems have been used as a backbone for the development of potent research tools, with Cas9 being the most widespread. While most of the utilized systems are DNA-targeting, recently more and more attention is being gained by those that target RNA. Their ability to specifically recognize a given RNA sequence in an easily programmable way makes them ideal candidates for developing new research tools. In this review we summarize current knowledge on CRISPR–Cas systems which have been shown to target RNA molecules, that is type III (Csm/Cmr), type VI (Cas13), and type II (Cas9). We also present a list of available technologies based on these systems.


PMLA ◽  
2016 ◽  
Vol 131 (2) ◽  
pp. 381-391 ◽  
Author(s):  
Emily Lethbridge ◽  
Steven Hartman

This essay discusses strategic efforts to develop new digital research tools and approaches as key elements of an inter-disciplinary research initiative in progress, Inscribing Environmental Memory in the Icelandic Sagas (IEM), which aims to study aspects of Icelandic literature, history, archaeology, environment, and geography in order to better understand societal responses to environmental change over the longue durée. The essay showcases a particular digital humanities project, Icelandic Saga Map (ISM), which not only provides an extremely useful tool for helping achieve many of the identified aims and methodological needs of an integrated environmental humanities initiative such as IEM but also is a valuable example of how innovative digital humanities tools can foster new research trajectories and open up new horizons for interdisciplinary engagement and synthesis of knowledge and diverse data.


2014 ◽  
Vol 211 (6) ◽  
pp. 861-869 ◽  
Author(s):  
G. Rinaldi ◽  
N. D. Young ◽  
J. D. Honeycutt ◽  
P. J. Brindley ◽  
R. B. Gasser ◽  
...  

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