scholarly journals USING GENE EXPRESSION AND OTHER NEW RESEARCH TOOLS TO ENHANCE AND JUDGE POULTRY PRODUCTION

2011 ◽  
Vol 48 (1) ◽  
pp. 313-313
Keyword(s):  
Gene Expression ◽  
Poultry Production ◽  
New Research ◽  
Research Tools

Epigenetics In Autoimmune Disease

2018 ◽  
Author(s):  
Matlock A Jeffries
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Autoimmune Disease ◽  
Noncoding Rna ◽  
Specific Treatment ◽  
Cell Types ◽  
Response To Therapy ◽  
Human Immune System ◽  
Treatment Regimens ◽  
New Research

Autoimmunity refers to a pathologic state of immunologic dysregulation in which the human immune system turns inward, attacking healthy tissues. The key step in this process is a break of self-immune tolerance. Recent studies have implicated dysregulation of gene expression via altered epigenetic control as a key mechanism in the development and promotion of autoimmunity. Epigenetics is defined as heritable changes in gene expression as a result of modification of DNA methylation, histone side chains, and noncoding RNA. Studies examining identical twins discordant for lupus, for example, were among the first to identify alterations in DNA methylation leading to lupus. Histone side-chain changes have been studied extensively in rheumatoid arthritis (RA), and many pathogenic cell types in RA exhibit a hyperacetylation phenotype. Finally, new research in the noncoding RNA field has not only uncovered potentially targetable pathways (e.g., miR-155) but may lead to the development of new diagnostic and prognostic biomarkers, helping physicians better tailor specific treatment regimens to improve response to therapy in autoimmune disease.   This review contains 4 figures, 1 table and 47 references Key Words: autoimmunity, big data, biomarkers, computational biology, DNA methylation, epigenetics, histone acetylation, histone methylation, microRNA, noncoding RNA

scholarly journals Embryonic Thermal Manipulation and in ovo Gamma-Aminobutyric Acid Supplementation Regulating the Chick Weight and Stress-Related Genes at Hatch

2022 ◽  
Vol 8 ◽  
Author(s):  
Akshat Goel ◽  
Chris Major Ncho ◽  
Chae-Mi Jeong ◽  
Yang-Ho Choi
Keyword(s):  
Gene Expression ◽  
Growth Performance ◽  
Organ Weight ◽  
Aminobutyric Acid ◽  
Poultry Production ◽  
Gamma Aminobutyric Acid ◽  
Related Gene ◽  
In Ovo ◽  
Stress Related Genes ◽  
Thermal Manipulation

Chickens are exposed to numerous types of stress from hatching to shipping, influencing poultry production. Embryonic manipulation may develop resistance against several stressors. This study investigates the effects of thermoneutral temperature (T0; 37.8°C) with no injection (N0) (T0N0), T0 with 0.6 ml of 10% in ovo gamma-aminobutyric acid (GABA) supplementation (N1) at 17.5th embryonic day (ED) (T0N1), thermal manipulation (T1) at 39.6°C from the 10th to 18th ED (6 h/day) with N0 (T1N0), and T1 with N1 (T1N1) on hatchability parameters and hepatic expression of stress-related genes in day-old Arbor Acres chicks. The parameters determined were hatchability, body weight (BW), organ weight, hepatic malondialdehyde (MDA), and antioxidant-related gene expression. Percent hatchability was calculated on a fertile egg basis. Growth performance was analyzed using each chick as an experimental unit. Eight birds per group were used for organ weight. Two-way ANOVA was used taking temperature and GABA as the main effect for growth performance and gene expression studies. Analysis was performed using an IBM SPSS statistics software package 25.0 (IBM software, Chicago, IL, USA). Hatchability was similar in all the groups and was slightly lower in the T1N1. Higher BW was recorded in both T1 and N1. Intestinal weight and MDA were higher in T0N1 against T0N0 and T1N1, respectively. The expression of HSP70, HSP90, NOX1, and NOX4 genes was higher and SOD and CAT genes were lower in the T1 group. The present results show that T1 and N1 independently improve the BW of broiler chicks at hatch, but T1 strongly regulates stress-related gene expression and suggests that both T1 and N1 during incubation can improve performance and alleviate stress after hatch.

scholarly journals Historical and legal discourse in the context of classical and postclassical legal understanding

2021 ◽  
pp. 106-111
Author(s):  
Tetiana Bondaruk
Keyword(s):  
Legal System ◽  
Legal Discourse ◽  
Radical Change ◽  
Legal Environment ◽  
Stage Of Development ◽  
Starting Point ◽  
Legal Space ◽  
New Research ◽  
Legal Understanding ◽  
Research Tools

Іntroduction. Historical and legal science, as well as the science of law in general, is acutely faced with challenges related to the new stage of development of humanities knowledge and the corresponding change of research paradigm that occurs during the struggle between classical and nonclassical (postclassical) types of legal understanding Тhe aim of the article. Тhese processes need to be understood and "adapted" in particular in the historical and legal discourse. In particular, it is proposed to analyze the phenomenon of deformation of the phenomenon of law, and the resulting differentiation of the subject, in particular in historical and legal research, and the coherence of research tools offered within the classical and nonclassical types of legal understanding Results. Modern methodological research is a natural reaction of the domestic legal process to the dominance of the monistic materialist approach to the study of legal phenomena, which actualizes anthropological and axiological approaches. Both anthropologization and axiologization of law cause the deformalization of the phenomenon of law, creating a conceptual In the light of the above, it seems important to consider in relation to the relationship such concepts as legal reality (historical and legal reality), legal life, legal system as central, and legal space, legal field, legal environment as peripheral. At the same time, attention is drawn to the normative nature of the legal system, the ontological nature of legal reality, the inconsistency of legal life as a starting point in the choice of methodological tools. Introduction to the historical and legal discourse of «ontological metaphors»: legal communication, legal event, legal life, legal space, legal field, legal environment, etc., will activate the intersubjective model of knowledge of law as a sociocultural phenomenon, draw attention to the dynamics of law, using an arsenal of non-classical methodology. Conclusions. An overview of some trends that lead to a change in the object and subject of jurisprudence shows a radical change in its methodology, which should form research tools to answer new research questions. This process is part of the process of modern «cultivation» of integrated thinking as opposed to or in addition to analytical and systemic, which is characterized by consideration of reality in mechanistic categories, and, being irreversible, requires appropriate historical and legal reflections

scholarly journals RNA-Targeting CRISPR–Cas Systems and Their Applications

2020 ◽  
Vol 21 (3) ◽  
pp. 1122 ◽  
Author(s):  
Michal Burmistrz ◽  
Kamil Krakowski ◽  
Agata Krawczyk-Balska
Keyword(s):  
Molecular Biology ◽  
Current Knowledge ◽  
Type Ii ◽  
Rna Molecules ◽  
Dna Targeting ◽  
Modern Molecular Biology ◽  
Rna Targeting ◽  
New Research ◽  
Target Rna ◽  
Research Tools

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)–CRISPR-associated (Cas) systems have revolutionized modern molecular biology. Numerous types of these systems have been discovered to date. Many CRISPR–Cas systems have been used as a backbone for the development of potent research tools, with Cas9 being the most widespread. While most of the utilized systems are DNA-targeting, recently more and more attention is being gained by those that target RNA. Their ability to specifically recognize a given RNA sequence in an easily programmable way makes them ideal candidates for developing new research tools. In this review we summarize current knowledge on CRISPR–Cas systems which have been shown to target RNA molecules, that is type III (Csm/Cmr), type VI (Cas13), and type II (Cas9). We also present a list of available technologies based on these systems.

Inscribing Environmental Memory in the Icelandic Sagas and the Icelandic Saga Map

PMLA ◽  
2016 ◽  
Vol 131 (2) ◽  
pp. 381-391 ◽  
Author(s):  
Emily Lethbridge ◽  
Steven Hartman
Keyword(s):  
Environmental Change ◽  
Digital Humanities ◽  
Environmental Humanities ◽  
New Horizons ◽  
Research Initiative ◽  
Literature History ◽  
New Research ◽  
Diverse Data ◽  
Digital Research ◽  
Research Tools

This essay discusses strategic efforts to develop new digital research tools and approaches as key elements of an inter-disciplinary research initiative in progress, Inscribing Environmental Memory in the Icelandic Sagas (IEM), which aims to study aspects of Icelandic literature, history, archaeology, environment, and geography in order to better understand societal responses to environmental change over the longue durée. The essay showcases a particular digital humanities project, Icelandic Saga Map (ISM), which not only provides an extremely useful tool for helping achieve many of the identified aims and methodological needs of an integrated environmental humanities initiative such as IEM but also is a valuable example of how innovative digital humanities tools can foster new research trajectories and open up new horizons for interdisciplinary engagement and synthesis of knowledge and diverse data.

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