Applicator for cervical brachytherapy for MRI or CT guided therapy

7537 Background: Radiotherapy is extremely important in extranodal natural killer/T-cell lymphoma (ENKTL). [18F]-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is a routine pretreatment imaging technique used in ENKTL, while magnetic resonance imaging (MRI) plays a key role in head and neck (HN) cancer. The purpose of this study was to investigate the value of pretreatment HN-MRI and PET/CT-guided therapy in improving survival in upper aerodigestive tract ENKTL (UADT-ENKTL). Methods: We prospectively conducted a single center study on untreated patients with pathologically diagnosed UADT-ENKTL. Patients undergoing PET/CT with/without HN-MRI were decided by clinicians for staging and restaging. The patients were treated with L-asparaginase/Pegaspargase and non-anthracycline-based chemotherapy with intensity-modulated radiation therapy (IMRT). Results: We enrolled 171 patients (median age, 44 years; range, 18-75 years; 118 (69%) males) from April 2011 to March 2018. Overall, 71 patients underwent PET/CT and HN-MRI (PET/CT-MRI) and 100 patients underwent PET/CT alone. HN-MRI upgraded the clinical stages in 8 patients (8/71) undergoing PET/CT based on the Ann Arbor staging system and in 10 patients (10/71) based on the TNM staging system by detecting additional local lesions ( P=0.011 and P=0.019, respectively). With a median follow-up of 54 months, the 5-year overall survival (OS), local recurrence-free survival (LRFS) and progression-free survival (PFS) rates were 72.7%, 68.6% and 68.2%, respectively, for all patients. The 5-year LRFS rate was 100% in the PET/CT-MRI group and 64.3% in the PET/CT group ( P<0.001). Similarly, the 5-year OS and PFS were longer in the PET/CT-MRI group than in the PET/CT group (84.5% vs. 67.8% and 78.3% vs. 65.6%; P=0.04 and P=0.03, respectively). Conclusions: HN-MRI and PET/CT-guided therapy could assist in decreasing local recurrence, which improved prognosis in UADT-ENKTL patients. Therefore, HN-MRI and PET/CT should be incorporated into routine pretreatment imaging examinations in patients with UADT-ENKTL. Clinical trial information: NCT01788137.

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Origami Lesion-Targeting Device for CT-Guided Interventions

Journal of Imaging ◽

10.3390/jimaging5020023 ◽

2019 ◽

Vol 5 (2) ◽

pp. 23

Author(s):

Austin Taylor ◽

Sheng Xu ◽

Bradford Wood ◽

Zion Tse

Keyword(s):

3D Printing ◽

Minimally Invasive ◽

Laser Cutting ◽

Low Cost ◽

Needle Insertion ◽

Ct Guided ◽

Surgical Tools ◽

Image Guided ◽

Radiocontrast Agent ◽

Guided Therapy

The objective of this study is to preliminarily evaluate a lesion-targeting device for CT-guided interventions. The device is created by laser cutting the structure from a sheet of medical grade paperboard, 3D printing two radiocontrast agent grids onto the surface and folding the structure into a rectangular prism with a viewing window. An abdominal imaging phantom was used to evaluate the device through CT imaging and the targeting of lesions for needle insertion. The lesion-targeting trials resulted in a mean targeting error of 2.53 mm (SD 0.59 mm, n = 30). The device is rigid enough to adequately support standard biopsy needles, and it attaches to the patient, reducing the risk of tissue laceration by needles held rigidly in place by an external manipulator. Additional advantages include adequate support for the insertion of multiple surgical tools at once for procedures such as composite ablation and the potential to guide off-axial needle insertion. The low-cost and disposability of the device make it well-suited for the minimally invasive image-guided therapy environment.

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Micro-invasive CT guided therapy for trigeminal neuralgia and atypical facial pain

Minimally Invasive Therapy ◽

10.3109/13645709409153031 ◽

1994 ◽

Vol 3 (6) ◽

pp. 323-329

Author(s):

G. J. Schmid ◽

R. M. M. Seibel ◽

D. H. W. Grönemeyer ◽

P. Van Leeuwen

Keyword(s):

Trigeminal Neuralgia ◽

Facial Pain ◽

Atypical Facial Pain ◽

Ct Guided ◽

Guided Therapy

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Breast Cancer Patient Auto-Setup Using Residual Neural Network for CT-Guided Therapy

IEEE Access ◽

10.1109/access.2020.3035809 ◽

2020 ◽

Vol 8 ◽

pp. 201666-201674

Author(s):

Chenning Liu ◽

Chenan Liu ◽

Fengquan Lv ◽

Kaibang Zhong ◽

Hongjin Yu

Keyword(s):

Breast Cancer ◽

Neural Network ◽

Cancer Patient ◽

Breast Cancer Patient ◽

Ct Guided ◽

Guided Therapy

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Interim PET-CT–guided therapy in elderly patients with Hodgkin lymphoma—a retrospective national multi-center study

Annals of Hematology ◽

10.1007/s00277-019-03686-y ◽

2019 ◽

Vol 98 (7) ◽

pp. 1665-1674 ◽

Cited By ~ 1

Author(s):

O. S. Bentur ◽

E. J. Dann ◽

E. Paran ◽

D. Lavie ◽

B. Nachmias ◽

...

Keyword(s):

Elderly Patients ◽

Hodgkin Lymphoma ◽

Ct Guided ◽

Interim Pet ◽

Pet Ct ◽

Multi Center Study ◽

Center Study ◽

Guided Therapy

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Origami Needle Guide for CT-Guided Interventions

10.20944/preprints201809.0342.v1 ◽

2018 ◽

Author(s):

Austin Taylor ◽

Sheng Xu ◽

Bradford J. Wood ◽

Zion Tsz Ho Tse

Keyword(s):

Standard Deviation ◽

3D Printing ◽

Laser Cutting ◽

Low Cost ◽

Needle Insertion ◽

Ct Guided ◽

Image Guided ◽

Radiocontrast Agent ◽

Horizontal Orientation ◽

Guided Therapy

The objective of this study is to preliminarily evaluate a new CT-biopsy guidance device, an origami needle guide. The device is created by laser cutting the structure from a sheet of cardboard, 3D printing two radiocontrast agent grids on to the surface and folding the structure into a rectangular prism with a viewing window. An abdominal imaging phantom was used to evaluate the device through CT imaging and the targeting of lesions for needle insertion. The lesion targeting trials resulted in a mean targeting error of 1.88 mm with a standard deviation of 0.73 mm. The device attaches to the patient and is rigid enough to adequately support standard biopsy needles, reducing the effect of gravity and the risk of laceration by the needles, making it potentially advantageous for biopsy of superficial lesions and lesions approached from a horizontal orientation. The device supports insertion of multiple needles at once, making it particularly suitable for composite ablation using multiple needles. Another advantage of the device is that it can guide off-axial needle insertion. The low-cost and disposability of the device make it well-suited for the minimally invasive image guided therapy environment.

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