Effect of low-dose aspirin on the development of ovarian hyperstimulation syndrome and outcomes of assisted reproductive techniques in the women with PCOS, a randomized double-blinded clinical trial

Abstract Background The rate of preterm births in Germany is 8.6%, which is very high compared to other European countries. As preterm birth contributes significantly to perinatal morbidity and mortality rates, the existing prevention strategies need to be optimized and expanded further. About ⅔ of all women with preterm birth have preterm labor or premature rupture of membranes. They are bracketed together under the term “spontaneous preterm birth” as opposed to iatrogenic preterm birth, for example as a consequence of preeclampsia or fetal growth retardation. Recent studies suggest that low-dose aspirin does not just reduce the rate of iatrogenic preterm births but can also further reduce the rate of spontaneous preterm births. This review article presents the current state of knowledge. Method A selective literature search up until April 2020 was done in PubMed, using the terms “randomized trial”, “randomized study”, “spontaneous preterm birth”, and “aspirin”. Results Secondary analyses of prospective randomized studies on the prevention of preeclampsia with low-dose aspirin show that this intervention also significantly reduced the rate of spontaneous preterm births in both high-risk and low-risk patient populations. The results of the ASPIRIN trial, a prospective, randomized, double-blinded multicenter study carried out in six developing countries, also point in this direction, with the figures showing that the daily administration of 81 mg aspirin starting before 14 weeks of gestation lowered the preterm birth rate of nulliparous women without prior medical conditions by around 11% (11.6 vs. 13.1%; RR 0.89; 95% CI: 0.81 – 0.98, p = 0.012). Conclusion Further studies on this issue are urgently needed. If these confirm the currently available results, then it would be worth discussing whether general aspirin prophylaxis for all pregnant women starting at the latest in 12 weeks of gestation is indicated.

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The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i9.7664 ◽

2020 ◽

Author(s):

Robab Davar ◽

Soheila Pourmasumi ◽

Banafsheh Mohammadi ◽

Maryam Mortazavi Lahijani

Keyword(s):

Clinical Trial ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Low Dose ◽

Endometrial Thickness ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Clinical Pregnancy Rates

Background: The results of previous studies on the effect of low-dose aspirin in frozenthawed embryo transfer (FET) cycles are limited and controversial. Objective: To evaluate the effect of low-dose aspirin on the clinical pregnancy in the FET cycles. Materials and Methods: This study was performed as a randomized clinical trial from May 2018 to February 2019; 128 women who were candidates for the FET were randomly assigned to two groups receiving either 80 mg oral aspirin (n = 64) or no treatment. The primary outcome was clinical pregnancy rate and secondary outcome measures were the implantation rate, miscarriage rate, and endometrial thickness. Results: The endometrial thickness was lower in patients who received aspirin in comparison to the control group. There were statistically significant differences between the two groups (p = 0.018). Chemical and clinical pregnancy rates and abortion rate was similar in the two groups and there was no statistically significant difference. Conclusion: The administration of aspirin in FET cycles had no positive effect on the implantation and the chemical and clinical pregnancy rates, which is in accordance with current Cochrane review that does not recommend aspirin administration as a routine in assisted reproductive technology cycles. Key words: Aspirin, Embryo transfer, Pregnancy rates.

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Low-Dose Aspirin for the Prevention and Treatment of Preeclampsia

50 Studies Every Obstetrician-Gynecologist Should Know ◽

10.1093/med/9780190947088.003.0002 ◽

2021 ◽

pp. 7-12

Author(s):

Danielle M. Panelli ◽

Deirdre J. Lyell

Keyword(s):

Lower Risk ◽

Low Dose ◽

Controlled Trial ◽

Entire Cohort ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Prevention And Treatment ◽

Double Blinded ◽

The Impact ◽

To Receive

“CLASP: A Randomized Trial of Low-Dose Aspirin for the Prevention and Treatment of Preeclampsia Among 9364 Pregnant Women” was a double-blinded, placebo-controlled trial that evaluated the impact of antenatal aspirin administration on development of preeclampsia and intrauterine growth restriction (IUGR). A total of 9364 women either at risk for preeclampsia or currently experiencing preeclampsia or IUGR were enrolled between 12 and 32 weeks and randomized to receive 60mg aspirin daily or placebo. While a nonsignificant 12% reduction in the odds of preeclampsia was found among the entire cohort, the reduction in preeclampsia with aspirin use was more pronounced for those who began prophylaxis prior to 20 weeks (22% reduction, p = 0.06). There was also a lower risk of preterm birth before 37 weeks in those who received aspirin at any time (19.7% vs. 22.2%, p = 0.003) but no difference in IUGR infants. In conclusion, 60mg aspirin daily did not significantly reduce the risk of preeclampsia or IUGR among the women included in this study.

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Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Elderly Japanese Patients with Atherosclerotic Risk Factors: Subanalysis of a Randomized Clinical Trial (JPPP-70)

American Journal of Cardiovascular Drugs ◽

10.1007/s40256-018-0313-0 ◽

2018 ◽

Vol 19 (3) ◽

pp. 299-311 ◽

Cited By ~ 1

Author(s):

Masahiro Sugawara ◽

◽

Yoshio Goto ◽

Tsutomu Yamazaki ◽

Tamio Teramoto ◽

...

Keyword(s):

Risk Factors ◽

Clinical Trial ◽

Cardiovascular Events ◽

Low Dose ◽

Japanese Patients ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Elderly Japanese ◽

Elderly Japanese Patients ◽

Atherosclerotic Risk Factors

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Randomized clinical trial of preconception low dose aspirin use and pregnancy loss: results from the eager trial

Fertility and Sterility ◽

10.1016/j.fertnstert.2014.07.186 ◽

2014 ◽

Vol 102 (3) ◽

pp. e54

Author(s):

S.L. Mumford ◽

L.L. Lesher ◽

M.V. White ◽

N.J. Perkins ◽

E.F. Schisterman ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Pregnancy Loss ◽

Low Dose ◽

Dose Aspirin ◽

Low Dose Aspirin

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Bipolar vs monopolar resection of bladder tumours of >3 cm in patients maintained on low-dose aspirin: A randomised clinical trial

Arab Journal of Urology ◽

10.1016/j.aju.2017.04.001 ◽

2017 ◽

Vol 15 (3) ◽

pp. 223-227 ◽

Cited By ~ 6

Author(s):

Mohamed M. Hashad ◽

Hussein M. Abdeldaeim ◽

Ahmed Moussa ◽

Akram Assem ◽

Tamer M. Abou Youssif

Keyword(s):

Clinical Trial ◽

Low Dose ◽

Randomised Clinical Trial ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Bladder Tumours

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Effect of Low Dose Aspirin in Low Risk Pregnant Ladies with Abnormal Uterine Artery Doppler Results, and the Evaluation of Maternal and Fetal outcomes: A Randomized Clinical Trial

Kurdistan Journal of Applied Research ◽

10.24017/science.2018.2.14 ◽

2018 ◽

pp. 85-89

Author(s):

Parzhin Jalal Ali ◽

Chro Najmaddin Fattah

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Uterine Artery ◽

Low Dose ◽

Low Risk ◽

The Other ◽

P Value ◽

Uterine Artery Doppler ◽

Dose Aspirin ◽

Low Dose Aspirin

This study aimed to identify the effect of low dose aspirin administration in low risk pregnant ladies who have abnormal uterine artery Doppler results. Patients and Methods: A randomized clinical trial was performed on 50 pregnant ladies (≥16 weeks of gestation) in Sulaymaniyah Maternity Teaching Hospital during January 2017 to January 2018. The participants were randomly enrolled into two groups; the participants in the first group were given 100 mg of aspirin tablet each but the other group was given nothing. Results: Preeclampsia was significantly (P-value of <0.001) less in the aspirin group as compared to the other group (16% and 40% respectively). The pulsatility index (PI) was not significantly different in both the groups (P-value = 0.69), but resistance index (RI) was significantly lower in the aspirin group (P-value of <0.001). Conclusion: Doppler study of the uterine artery at 16 weeks or higher in low risk pregnant women appears to be useful as a screening test and low dose of aspirin therapy at early stage of pregnancy will decrease the incidence of preeclampsia.

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