Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson’s disease

Toxicology ◽  
2020 ◽  
Vol 436 ◽  
pp. 152437 ◽  
Author(s):  
Wenbin Ding ◽  
Hongyan Lin ◽  
Xin Hong ◽  
Dongliang Ji ◽  
Feng Wu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Poloxamer 188 ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease

2018 ◽  
Vol 9 (12) ◽  
pp. 6414-6426 ◽  
Author(s):  
Li-fan Zhang ◽  
Xiao-lin Yu ◽  
Mei Ji ◽  
Shu-ying Liu ◽  
Xiao-ling Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Neuroprotective Effects

Resveratrol exerts neuroprotective effects on the A53T α-synuclein mouse model of Parkinson's disease.

scholarly journals Human Amniotic Epithelial Cells Recover Mouse model of Parkinson’s Disease mainly by Neuroprotective，Anti-oxidative and Anti-inflammatory factors

2020 ◽  
Author(s):  
Jiaofei Zhang ◽  
Hui Li ◽  
Hao Yang ◽  
Jianhua Lin ◽  
You Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Epithelial Cells ◽  
Mouse Model ◽  
Inflammatory Factors ◽  
Amniotic Epithelial Cells ◽  
Human Amniotic Epithelial Cells ◽  
Anti Inflammatory

Abstract The authors have withdrawn this preprint due to author disagreement.

Anti-inflammatory effects of usnic acid in an MPTP-induced mouse model of Parkinson’s disease

2020 ◽  
Vol 1730 ◽  
pp. 146642 ◽  
Author(s):  
Seulah Lee ◽  
Yujeong Lee ◽  
Sugyeong Ha ◽  
Hae Young Chung ◽  
Hangun Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Usnic Acid ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1855
Author(s):  
Seulah Lee ◽  
Yeon Ji Suh ◽  
Yujeong Lee ◽  
Seonguk Yang ◽  
Dong Geun Hong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Cell Activation ◽  
Motor Dysfunction ◽  
Dopamine Neurons ◽  
Neuroprotective Effects ◽  
Glial Cell Activation ◽  
Anti Inflammatory ◽  
Neuroprotective Treatment

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined the neuroprotective effects of the barbiturate derivative, MHY2699 [5-(4-hydroxy 3,5-dimethoxybenzyl)-2 thioxodihydropyrimidine-4,6(1H,5H)-dione] in a mouse model of PD. MHY2699 ameliorated MPP⁺-induced astrocyte activation and ROS production in primary astrocytes and inhibited the MPP⁺-induced phosphorylation of MAPK and NF-κB. The anti-inflammatory effects of MHY2699 in protecting neurons were examined in an MPTP-induced mouse model of PD. MHY2699 inhibited MPTP-induced motor dysfunction and prevented dopaminergic neuronal death, suggesting that it attenuated neuroinflammation. Overall, MHY2699 has potential as a neuroprotective treatment for PD.

scholarly journals Cognitive deficits in a mouse model of pre-manifest Parkinson’s disease

2012 ◽  
Vol 35 (6) ◽  
pp. 870-882 ◽  
Author(s):  
Iddo Magen ◽  
Sheila M. Fleming ◽  
Chunni Zhu ◽  
Eddie C. Garcia ◽  
Katherine M. Cardiff ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Cognitive Deficits
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