Suitability of high-resolution mass spectrometry in analytical toxicology: Focus on drugs of abuse

2021 ◽  
Author(s):  
Ruben Goncalves ◽  
Romain Pelletier ◽  
Aurélien Couette ◽  
Thomas Gicquel ◽  
Brendan Le Daré
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Drugs Of Abuse ◽  
High Resolution Mass Spectrometry ◽  
Analytical Toxicology ◽  
High Resolution Mass ◽  
Resolution Mass

scholarly journals Hyphenated high-resolution mass spectrometry—the “all-in-one” device in analytical toxicology?

2020 ◽  
Author(s):  
Hans H. Maurer
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Forensic Toxicology ◽  
Analytical Toxicology ◽  
High Resolution Mass ◽  
Scientific Meetings ◽  
Application Fields ◽  
Clinical And Forensic Toxicology ◽  
Resolution Mass

AbstractThis trend article reviews papers with hyphenated high-resolution mass spectrometry (HRMS) approaches applied in analytical toxicology, particularly in clinical and forensic toxicology published since 2016 and referenced in PubMed. The article focuses on the question of whether HRMS has or will become the all-in-one device in these fields as supposed by the increasing number of HRMS presentations at scientific meetings, corresponding original papers, and review articles. Typical examples for the different application fields are discussed such as targeted or untargeted drug screening, quantification, drug metabolism studies, and metabolomics approaches. Considering the reviewed papers, HRMS is currently the only technique that fulfills the criteria of an all-in-one device for the various applications needed in analytical toxicology.Graphical abstract

Potential of High-Resolution Mass Spectrometry for the Detection of Drugs and Metabolites in Hair: Methoxetamine in a Real Forensic Case

2020 ◽  
Author(s):  
J M Matey ◽  
Adrián López-Fernández ◽  
Carmen García-Ruiz ◽  
Gemma Montalvo ◽  
M D Moreno ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Drugs Of Abuse ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Low Concentrations ◽  
Forensic Case ◽  
High Resolution Technique ◽  
The One ◽  
Resolution Mass

Abstract The analysis of drugs of abuse in hair and other biological matrices of forensic interest requires great selectivity and sensitivity. This is done traditionally through target analysis, with one or more analytical methods, or with different and specific preanalytical phases, and complex procedures performed by the toxicological laboratories, and there is no exception with ketamine-like compounds, such as methoxetamine, a new psychoactive substance whose use has increased in the last decades, and continues to grow quickly year by year. More validated methods of analysis are needed to detect these substances in low concentrations selectively. Reanalyzing the samples of a former case of a polydrug consumer accused of a crime against public health in Spain, five metabolites of methoxetamine (normethoxetamine, O-desmethylmethoxetamine, dehydromethoxetamine, dihydronormethoxetamine and hydroxynormethoxetamine) were tentatively detected using a high-resolution technique, i.e., liquid chromatography coupled to high-resolution mass spectrometry (LC–HR-MS-MS). The highest analytical selectivity of LC–HR-MS-MS method together a universal and simpler pretreatment stages has demonstrated to allow faster analysis and more sensitivity than the one performed traditionally at the INTCF laboratories, which was gas chromatography coupled to mass spectrometry.

(Un)targeted Scanning of Locks of Hair for Drugs of Abuse by Direct Analysis in Real Time–High-Resolution Mass Spectrometry

2016 ◽  
Vol 88 (4) ◽  
pp. 2489-2496 ◽  
Author(s):  
Wilco F. Duvivier ◽  
Marc R. van Putten ◽  
Teris A. van Beek ◽  
Michel W. F. Nielen
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Real Time ◽  
Drugs Of Abuse ◽  
High Resolution Mass Spectrometry ◽  
Direct Analysis ◽  
High Resolution Mass ◽  
Resolution Mass
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