New advances in vivo mutagenicity tests: Application of the guidance of the European Food Safety Authority

2015 ◽  
Vol 238 (2) ◽  
pp. S17-S18
Author(s):  
R. Crebelli ◽  
M. Carfì ◽  
J.M. Parra Morte ◽  
A.M. Rossi ◽  
M.V. Vettori ◽  
...  
Author(s):  
Ilse-Dore Adler ◽  
James Bootman ◽  
John Favor ◽  
Graham Hook ◽  
Gerlinde Schriever-Schwemmer ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2095
Author(s):  
Pedro Estevan Navarro ◽  
Isabel Sospedra ◽  
Alejandro Perales ◽  
Cristina González-Díaz ◽  
Rubén Jiménez-Alfageme ◽  
...  

Caffeine is a food supplement widely consumed by athletes, but it has not been established. So far, the veracity of their labeling in terms of the dosage and cause/effect relationship aimed at the consumer. The aim is to analyze the health claims and the dosage presented on the labeling of caffeine supplements and to evaluate if they follow the European Food Safety Authority (EFSA) and international criteria. A descriptive cross-sectional study of a sample of caffeine supplements was carried out. The search was done through the Amazon and Google Shopping web portals. In order to assess the adequacy of the health claims, the guidelines of reference established by European Food Safety Authority were compared to the Academy of Nutrition and Dietetics, International Olympic Committee, and Australian Institute of Sport guidelines; in addition, recent systematic reviews were addressed. A review of labels of 42 caffeine supplements showed that, in less than 3% of the products were the health claims supported by the recommendations and by the labeled quantity of caffeine. The claims that fully complied the recommendations were, “improves or increases endurance performance”, “improves strength performance”, or “improves short-term performance”. In most cases, the recommended dosage was 200 mg/day for these products, which is the minimum for the caffeine effects to be declared. The rest of the health claims were not adequate or need to be modified. Most of the health claims identified indicated an unproven cause and effect, which constitutes consumer fraud, and so must be modified or eliminated.


Mutagenesis ◽  
2004 ◽  
Vol 19 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Leslie Recio ◽  
Maria Donner ◽  
Diane Abernethy ◽  
Linda Pluta ◽  
Ann‐Marie Steen ◽  
...  

2017 ◽  
Vol 19 (3) ◽  
pp. 168-182
Author(s):  
Caer Smyth

In 2015, the International Agency for Research on Cancer of the World Health Organisation published a monograph stating that glyphosate, the active ingredient in Roundup, Monsanto’s leading herbicide, was ‘probably carcinogenic to humans’. Shortly after this, the European Food Safety Authority re-assessed glyphosate’s licence for use in the European Union, and deemed it to be safe for human use. Both of these expert advisory bodies faced condemnation and accusations of political bias as a result of these assessments. Employing Jasanoff’s ‘three-body problem’, this article examines the conflicting conclusions of the International Agency for Research on Cancer and the European Food Safety Authority, exploring what the contested assessments of glyphosate reveal about the entangled relationship between scientific expertise and law-making.


2021 ◽  
Vol 3 ◽  
Author(s):  
Rositsa Serafimova ◽  
Tamara Coja ◽  
George E. N. Kass

The safety assessment of chemicals added or found in food has traditionally made use of data from in vivo studies performed on experimental animals. The nature and amount of data required to carry out a risk assessment is generally stipulated either in the different food legislations or in sectoral guidance documents. However, there are still cases where no or only limited experimental data are available or not specified by law, for example for contaminants or for some minor metabolites from active substances in plant protection products. For such cases, the Threshold of Toxicological Concern (TTC) can be applied. This review explores the use of the TTC approach in food safety in the European Union, in relation to the different food sectors, legal requirements and future opportunities.


2016 ◽  
Vol 70 (8) ◽  
pp. 741-745 ◽  
Author(s):  
Christopher J Portier ◽  
Bruce K Armstrong ◽  
Bruce C Baguley ◽  
Xaver Baur ◽  
Igor Belyaev ◽  
...  

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