Exposure to biomass smoke induces pulmonary Th17 cell differentiation by activating TLR2 on dendritic cells in a COPD rat model

2021 ◽  
Author(s):  
Jinding Pu ◽  
Juan Xu ◽  
Lu Chen ◽  
Hongbin Zhou ◽  
Weitao Cao ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Differentiation ◽  
Rat Model ◽  
Th17 Cell ◽  
Biomass Smoke ◽  
Th17 Cell Differentiation

scholarly journals Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation

2021 ◽  
Vol 22 (14) ◽  
pp. 7535
Author(s):  
Hye-Soo Park ◽  
Seunga Choi ◽  
Yong-Woo Back ◽  
Kang-In Lee ◽  
Han-Gyu Choi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mycobacterium Tuberculosis ◽  
Cell Differentiation ◽  
Prostaglandin E2 ◽  
Th17 Cell ◽  
Th17 Cells ◽  
Bacterial Load ◽  
Cell Responses ◽  
Ep4 Receptor ◽  
Th17 Cell Differentiation

Prostaglandin E2 (PGE2) is an important biological mediator involved in the defense against Mycobacterium tuberculosis (Mtb) infection. Currently, there are no reports on the mycobacterial components that regulate PGE2 production. Previously, we have reported that RpfE-treated dendritic cells (DCs) effectively expanded the Th1 and Th17 cell responses simultaneously; however, the mechanism underlying Th1 and Th17 cell differentiation is unclear. Here, we show that PGE2 produced by RpfE-activated DCs via the MAPK and cyclooxygenase 2 signaling pathways induces Th1 and Th17 cell responses mainly via the EP4 receptor. Furthermore, mice administered intranasally with PGE2 displayed RpfE-induced antigen-specific Th1 and Th17 responses with a significant reduction in bacterial load in the lungs. Furthermore, the addition of optimal PGE2 amount to IL-2-IL-6-IL-23p19-IL-1β was essential for promoting differentiation into Th1/Th17 cells with strong bactericidal activity. These results suggest that RpfE-matured DCs produce PGE2 that induces Th1 and Th17 cell differentiation with potent anti-mycobacterial activity.

scholarly journals REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells

2019 ◽  
Vol 17 (11) ◽  
pp. 1136-1147 ◽  
Author(s):  
Lei Zhou ◽  
Liangfang Yao ◽  
Qing Zhang ◽  
Wei Xie ◽  
Xiaoshuang Wang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Differentiation ◽  
Th17 Cell ◽  
Autoimmune Inflammation ◽  
Th17 Cell Differentiation

scholarly journals Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

Immunity ◽  
2014 ◽  
Vol 40 (4) ◽  
pp. 594-607 ◽  
Author(s):  
Yoshiyuki Goto ◽  
Casandra Panea ◽  
Gaku Nakato ◽  
Anna Cebula ◽  
Carolyn Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Differentiation ◽  
Th17 Cell ◽  
Filamentous Bacteria ◽  
Segmented Filamentous Bacteria ◽  
Th17 Cell Differentiation
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