scholarly journals Loss of tumor suppressive properties of lipid metabolism enzyme CPT2 in ovarian carcinoma: Comment on “CPT2 down-regulation promotes tumor growth and metastasis through inducing ROS/NFκB pathway in ovarian cancer” by Zhang et al.

2021 ◽  
Vol 14 (7) ◽  
pp. 101067
Author(s):  
Panagiotis J. Vlachostergios
Keyword(s):  
Ovarian Cancer ◽  
Lipid Metabolism ◽  
Tumor Growth ◽  
Ovarian Carcinoma ◽  
Down Regulation ◽  
Metabolism Enzyme ◽  
Tumor Growth And Metastasis ◽  
Nfκb Pathway

scholarly journals CPT2 Down-Regulation Promotes Tumor Growth and Metastasis Through Inducing ROS/NFκB Pathway in Ovarian Cancer

2020 ◽  
Author(s):  
Xiaohong Zhang ◽  
Zhen Zhang ◽  
Shujuan Liu ◽  
Jia Li ◽  
Liying Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Down Regulation ◽  
Tumor Growth And Metastasis ◽  
Nfκb Pathway

scholarly journals CPT2 down-regulation promotes tumor growth and metastasis through inducing ROS/NFκB pathway in ovarian cancer

2021 ◽  
Vol 14 (4) ◽  
pp. 101023
Author(s):  
Xiaohong Zhang ◽  
Zhen Zhang ◽  
Shujuan Liu ◽  
Jia Li ◽  
Liying Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Down Regulation ◽  
Tumor Growth And Metastasis ◽  
Nfκb Pathway

The Dynamic Metastases of Human Ovarian Carcinoma to Grading Lymph Nodes in Mouse Model

2020 ◽  
Author(s):  
Licheng Du ◽  
Fenghua Kong ◽  
Qing Yang ◽  
Yaqiong Li ◽  
Peikai Ding ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Lymph Nodes ◽  
Ovarian Carcinoma ◽  
Underlying Mechanism ◽  
Computer Assisted ◽  
Primary Tumors ◽  
Lymphogenous Metastasis ◽  
Cell Dissemination ◽  
And Control

Abstract Background：Lymphogenous metastasis, one of the most common dissemination routes for ovarian carcinoma, predicts a poor prognosis and relates to most cancer-related death. Now there were no effective therapy and control methods for ovarian carcinoma. Hence, it is necessary to build an animal model of lymph node metastasis in ovarian cancer to seek for the tools to find effective treatments. Our purpose of this study was to investigate the tumor cell dissemination of ovarian carcinoma to the gradient lymph nodes of nude mice and its possible mechanism. Methods: The mice models of VEGF-D over-expressed were built and the tumor growth and sentinel lymph nodes were evaluated weekly, while the visible lymph nodes and tumor masses were excised for histological examination using HE examination. Then Evan’s Blue was conducted to observe the unveil lymphatic network. Subsequently, immunohistochemistry was performed to check the expression of relative genes. Meanwhile, microvessel counting was performed within the tumor tissues and measured using computer assisted morphometric analysis.Results: The over-expression of VEGF-D promoted the tumor growth of ovarian carcinoma, facilitated the hyperplasia of tumor lymphatic and increased the intratumoral lymphatic vessel density. Besides, the up-regulation of VEGF-D induced the expression of MMP-2, which might be the underlying mechanism for the lymph metastasis in ovarian cancer. Conclusion: It was a step-by-step progression from the inoculation of cancer cells, to the proliferation of the primary tumors, and then to the lymphatic metastases, in which VEGF-D and MMP-2 played vital roles.

scholarly journals CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFκB pathway in hepatocellular carcinoma

2020 ◽  
Vol 11 (5) ◽  
Author(s):  
Hulin Chang ◽  
Juntang Li ◽  
Kai Qu ◽  
Yong Wan ◽  
Sinan Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Tumor Growth And Metastasis ◽  
Nfκb Pathway

scholarly journals Correction: Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells

Oncotarget ◽  
2020 ◽  
Vol 11 (32) ◽  
pp. 3103-3104
Author(s):  
Sham S. Kakar ◽  
Seema Parte ◽  
Kelsey Carter ◽  
Irving G. Joshua ◽  
Christopher Worth ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Tumor Growth ◽  
Withaferin A ◽  
Ovarian Cancer Stem Cells ◽  
Tumor Growth And Metastasis

scholarly journals Hypoxia Regulated Inhibin Promotes Tumor Growth and Vascular Permeability By ACVRL1 and CD105 Dependent VE-Cadherin Internalization

2021 ◽  
Author(s):  
Karthikeyan Mythreye ◽  
Ben Horst ◽  
Shrikant Pradhan ◽  
Roohi Chaudhary ◽  
Eduardo Listik ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Ovarian Cancer Cell ◽  
Vascular Normalization ◽  
Cancer Management ◽  
Vessel Normalization ◽  
Ovarian Cancer Cell Lines ◽  
Tumor Growth And Metastasis ◽  
Early Tumor

Abstract Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. However, toxicities and resistance to anti-angiogenics limits their use making identification of new targets vital. Inhibin, a heteromeric TGFb ligand, is a contextual regulator of tumor progression acting as an early tumor suppressor, yet also an established biomarker for ovarian cancers. Here, we demonstrate a previously unknown role for inhibins and find that hypoxia increases inhibin levels in ovarian cancer cell lines, xenograft tumors, and patients. Inhibin is regulated specifically through HIF-1, shifting the balance from activins to inhibins. Hypoxia regulated inhibin promotes tumor growth, endothelial cell invasion and permeability. Targeting inhibin in vivo through knockdown and anti-inhibin strategies robustly reduces permeability in vivo and alters the balance of pro and anti-angiogenic mechanisms resulting in vascular normalization. Mechanistically, inhibin regulates permeability by increasing VE-cadherin internalization via ACVRL1 and CD105, a receptor complex that we find stabilized directly by inhibin. Our findings are the first to demonstrate direct roles for inhibins in vascular normalization via TGF-b receptors providing new insights into the therapeutic significance of inhibins as a strategy to normalize the tumor vasculature in ovarian cancer.

scholarly journals Epithelial/mesenchymal heterogeneity of high‐grade serous ovarian carcinoma samples correlates with miRNA let‐7 levels and predicts tumor growth and metastasis

2020 ◽  
Vol 14 (11) ◽  
pp. 2796-2813
Author(s):  
Evgeny Chirshev ◽  
Nozomi Hojo ◽  
Antonella Bertucci ◽  
Linda Sanderman ◽  
Anthony Nguyen ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Ovarian Carcinoma ◽  
High Grade ◽  
Serous Ovarian Carcinoma ◽  
Tumor Growth And Metastasis
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