Resistant oral mucosal lesions in pemphigus vulgaris responsive to double filtration plasmapheresis: First case report from Turkey

2013 ◽  
Vol 48 (2) ◽  
pp. 273-275 ◽  
Author(s):  
E. Şavk ◽  
M. Uslu ◽  
I. Yavaşoğlu ◽  
G. Kadıköylü ◽  
N. Şendur ◽  
...  
Keyword(s):  
Case Report ◽  
Pemphigus Vulgaris ◽  
Double Filtration Plasmapheresis ◽  
First Case ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions ◽  
Double Filtration

scholarly journals Double Filtration Plasmapheresis Treatment of Refractory Multiple Sclerosis Relapsed on Fingolimod: A Case Report

2020 ◽  
Vol 10 (21) ◽  
pp. 7404
Author(s):  
Roberto De Masi ◽  
Stefania Orlando ◽  
Salvatore Accoto
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Improvement ◽  
Gamma Globulin ◽  
Neurological Diseases ◽  
Methyl Prednisolone ◽  
Double Filtration Plasmapheresis ◽  
First Case ◽  
Double Filtration ◽  
Steroid Refractory ◽  
Inflammatory Effect

Double filtration plasmapheresis (DFPP) is an emerging semi-selective apheretic method for treating immuno-mediated neurological diseases. Here we report the first case of steroid-refractory relapsed multiple sclerosis (MS) on Fingolimod (FTY), treated effectively by this technique, in a 37-year-old woman. This condition is thought to be caused by soluble inflammatory species, but its demyelinating pattern is unknown; moreover, despite megadoses of intravenous 6-methyl prednisolone, it induces severe neurological deterioration, but dramatically responded to DFPP in our patient. The clinical improvement was driven by a strong DFPP-induced anti-inflammatory effect, with significant reduction of C3/C4 components, total gamma globulin concentrations (IgG), and gamma-fibrinogen (FGG), resulting in a brain pseudoatrophy phenomenon. Our findings are: first, the steroid-refractory relapsed MS on FTY, however serious, can be treated with DFPP; second, given the good clinical improvement due to the DFPP-induced neuroinflammatory components removal, this clinical condition can be associated with a Lucchinetti pattern II of demyelination.

scholarly journals Successful treatment of steroid-resistant anti-aquaporin 4 antibody-positive optic neuritis with double-filtration plasmapheresis: a case report

2018 ◽  
Vol 51 (6) ◽  
pp. 379-385
Author(s):  
Kei Fukuda-Hihara ◽  
Masayuki Iyoda ◽  
Tomohiro Saito ◽  
Noriko Arai-Nunota ◽  
Yukihiro Wada ◽  
...  
Keyword(s):  
Case Report ◽  
Optic Neuritis ◽  
Successful Treatment ◽  
Aquaporin 4 ◽  
Steroid Resistant ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration ◽  
Aquaporin 4 Antibody

scholarly journals Double filtration plasmapheresis was effective in the treatment of a case of pemphigus vulgaris with multiple organ failure.

1994 ◽  
Vol 27 (7) ◽  
pp. 1091-1094
Author(s):  
Yukihiko Matsuno ◽  
Hiroshi Oda ◽  
Hiroshige Ohashi ◽  
Yasunori Kotoo ◽  
Sachirou Watanabe ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Pemphigus Vulgaris ◽  
Multiple Organ ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

scholarly journals Oral mucosal lesions in patients with pemphigus and pemphigoid skin diseases: a cross sectional study from southern India.

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Arvind Babu Rajendra Santosh ◽  
Venkat Ramana Reddy Baddam ◽  
Chigurupati Anuradha ◽  
Chandrashekar Poosarla
Keyword(s):  
Skin Diseases ◽  
Disease Process ◽  
Pemphigus Vulgaris ◽  
Diagnostic Procedures ◽  
Cross Sectional Study ◽  
Southern India ◽  
Cross Sectional ◽  
Autoimmune Blistering Disease ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Objective:To assess the prevalence of oral mucosal lesions in patients with pemphigus and pemphigoid diseases from Southern India. Design and Methods: A cross-sectional hospital based study was conducted from August 2010 to July 2011. Patients with confirmed pemphigus and pemphigoid skin disease were selected and informed to participate in the study. Oral examination of all participants were done to document site and type of oral manifestation and diagnostic procedures such as histopathological and Immunofluorescence methods were performed to confirm the diagnosis. Demographic details such as age, gender and occupation were also documented. The results of the study were analyzed by SPSS software version 19.0 (Armonk, NY) and presented as descriptive statistics. Results: Sixty percent of the patients exhibited oral mucosal manifestations. A higher female (86.66%) predilection of autoimmune blistering disease was observed in the study. A slightly higher number of pemphigoid patients (53.33%, 16 out of 30) were reported than pemphigus (46.66%, 14 out of 30 cases). The most common subtypes of pemphigus is Pemphigus vulgaris 71% (10 out of 14) among pemphigus, and bullous pemphigoid 87.5%(14 out of 16) among pemphigoid. Buccal mucosa (92.85%) is the most common site in pemphigus patients, where as hard palate (12.5%) is mostly commonly reported site in pemphigoid patients. Initial involvement of oral tissue in disease process was observed in 78.57% of pemphigus, and 12.5% of pemphigoid patients. Conclusion: Oral mucosal lesions are more frequently associated in pemphigus patients. Oral mucosal lesions are the initial site of disease process in pemphigus patients. The significance of diagnosis of oral lesions at earlier stage of disease, specifically pemphigus may help in early intervention of disease and help to reduce the morbidity and mortality state. The study emphasizes multidisciplinary approach in diagnosis and management of both pemphigus and pemphigoid.

scholarly journals A case of pemphigus vulgaris of the oral mucosa that responded to double-filtration plasmapheresis

2006 ◽  
Vol 52 (10) ◽  
pp. 556-559
Author(s):  
Miki ISHIBASHI ◽  
Kazuma NOGUCHI ◽  
Norio MASUDA ◽  
Kazunari SAKURAI ◽  
Masahiro URADE
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

scholarly journals Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report

2017 ◽  
Vol 21 (2) ◽  
pp. 119-122
Author(s):  
Athanasios Poulopoulos ◽  
Fotios Iordanidis ◽  
Dimitrios Andreadis ◽  
Konstantinos Antoniadis
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Granulocytic Sarcoma ◽  
Unknown Origin ◽  
Malignant Tumour ◽  
Myeloid Sarcoma ◽  
Initial Manifestation ◽  
First Case ◽  
Oral Mucosal Lesions ◽  
Solid Malignant Tumour

SummaryBackground: Myeloid sarcoma (MS) is a solid malignant tumour associated with infiltration of immature myeloid precursor cells in an extramedullary site. The term MS has replaced the term granulocytic sarcoma and chloroma, which were used in the past. MS in the oral cavity is very uncommon, with less of 40 cases reported until recently. Case Report: We report the first case, the features, and the diagnostic sequence, of intraoral MS with bilateral palatal involvement, which presented as an initial manifestation, and preceded the appearance of acute myeloid leukaemia (AML). Diagnostic confirmation of such oral mucosal lesions usually requires biopsy, histopathological examination with additional immunohistochemical investigation. MS can occur during the course of acute or chronic myelogenous leukaemia, and myelodysplastic syndromes. In the vast majority of the reported cases, only one site was involved with a single intraoral MS lesion, and the cases predominantly associated with AML. Conclusion: The majority of intraoral MS occurs in patients with known AML, but in some of them, presented as an initial manifestation, and preceded the appearance of the disease. Therefore, clinicians should carefully evaluate all unusual oral lesions of unknown origin.

Double filtration plasmapheresis in an ABO-incompatible renal transplantation: a case report

2003 ◽  
Vol 35 (1) ◽  
pp. 227-229 ◽  
Author(s):  
H Kawamura ◽  
M Matsumura ◽  
Y Kishi ◽  
K Fujikawa ◽  
K Uchiyama ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplantation ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration
Sign in / Sign up

Export Citation Format

Share Document