Human Hepatoma HepaRG Cell Line Engraftment in Severe Combined Immunodeficient × Beige Mice Using Mouse-Specific Anti-Fas Antibody

2010 ◽  
Vol 42 (9) ◽  
pp. 3773-3778 ◽  
Author(s):  
L. Jiang ◽  
J.G. Li ◽  
L. Lan ◽  
Y.M. Wang ◽  
Q. Mao ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Hepatoma ◽  
Heparg Cell ◽  
Heparg Cell Line

scholarly journals Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor

Hepatology ◽  
2007 ◽  
Vol 45 (4) ◽  
pp. 957-967 ◽  
Author(s):  
Virginie Cerec ◽  
Denise Glaise ◽  
Delphine Garnier ◽  
Serban Morosan ◽  
Bruno Turlin ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Hepatoma ◽  
Heparg Cell ◽  
Heparg Cell Line

scholarly journals Assessing hepatoprotective effects of antioxidants on amiodarone-induced cytotoxicity in human hepatoma HepaRG cell line

2021 ◽  
Author(s):  
KS Filimonova ◽  
NYu Rogovskaya ◽  
PP Beltyukov ◽  
VN Babakov
Keyword(s):  
Cell Line ◽  
P53 Protein ◽  
Toxic Effects ◽  
Human Hepatoma ◽  
Cell Cycle Regulators ◽  
Human Hepatoma Cells ◽  
Heparg Cell ◽  
Heparg Cell Line ◽  
Ic50 Value ◽  
Hepatoprotective Effects

Effective therapy of amiodarone-induced hepatotoxicity requires studying the mechanisms of the toxic effects of amiodarone on hepatocytes and assessing the potential impact of hepotoprotective agents. The study was aimed to assess hepatoprotective effects of antioxidants on the amiodarone-induced hepatotoxicity with the use of immortalized human hepatoma cells of the HepaRG cell line. Cell viability was evaluated upon exposure to amiodarone and in the mixture with vitamin Е, N-acetylcysteine and S-adenosylmethionine by impedance measurement; the levels of some hepatotoxicity biomarkers were defined using the Luminex xMAP technology. As a result of the research, the dose-dependent toxic effects of amiodarone were established. The IC50 value of amiodarone in the HepaRG cell line was 3.5 μМ. It is shown that cytotoxic effects decrease and the IC50 value increases in the presence of vitamin Е, N-acetylcysteine and S-adenosylmethionine. Amiodarone reduces the activity of cell cycle regulators: AKT, JNK kinases, and p53 protein. Exposure to amiodarone results in reduced intracellular ATP levels and the release of intracellular enzymes (malate dehydrogenase 1, glutathione S-transferase, sorbitol dehydrogenase, 5'-nucleotidase) into conditioned medium, indicating the necrotic cell death. Thus, vitamin Е, S-adenosylmethionine and N-acetylcysteine reduce amiodarone cytotoxicity in the model of amiodarone-induced damage to hepatocytes and can be considered as hepatoprotective agents in case of the need to protect liver against the hepatotoxic effects of amiodarone.

Ethanol Effect on Cell Proliferation in the Human Hepatoma HepaRG Cell Line: Relationship With Iron Metabolism

2010 ◽  
Vol 35 (3) ◽  
pp. 408-419 ◽  
Author(s):  
Thi Hong Tuoi Do ◽  
François Gaboriau ◽  
Martine Ropert ◽  
Romain Moirand ◽  
Isabelle Cannie ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Line ◽  
Iron Metabolism ◽  
Human Hepatoma ◽  
Heparg Cell ◽  
Heparg Cell Line ◽  
Ethanol Effect ◽  
Line Relationship

Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

2006 ◽  
Vol 28 (1-2) ◽  
pp. 109-117 ◽  
Author(s):  
Marc Le Vee ◽  
Emilie Jigorel ◽  
Denise Glaise ◽  
Philippe Gripon ◽  
Christiane Guguen-Guillouzo ◽  
...  
Keyword(s):  
Cell Line ◽  
Drug Transporters ◽  
Functional Expression ◽  
Human Hepatoma ◽  
Hepatic Drug ◽  
Heparg Cell ◽  
Heparg Cell Line

scholarly journals Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line

2018 ◽  
Vol 9 ◽  
Author(s):  
Longtai You ◽  
Xiaoxv Dong ◽  
Boran Ni ◽  
Jing Fu ◽  
Chunjing Yang ◽  
...  
Keyword(s):  
Cell Line ◽  
Heparg Cell ◽  
Heparg Cell Line

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

2012 ◽  
Vol 8 (7) ◽  
pp. 909-920 ◽  
Author(s):  
Tommy B Andersson ◽  
Kajsa P Kanebratt ◽  
John Gerry Kenna
Keyword(s):  
Drug Metabolism ◽  
Cell Line ◽  
Heparg Cell ◽  
Heparg Cell Line

scholarly journals Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line

2018 ◽  
Vol 5 ◽  
pp. 819-826 ◽  
Author(s):  
Robin Mesnage ◽  
Martina Biserni ◽  
Eva Wozniak ◽  
Theodoros Xenakis ◽  
Charles A. Mein ◽  
...  
Keyword(s):  
Cell Line ◽  
Heparg Cell ◽  
Heparg Cell Line

scholarly journals In-vitro evaluation of DDI with cobicistat and ritonavir using heparg cell line

2015 ◽  
Vol 37 (8) ◽  
pp. e98
Author(s):  
F. Storelli ◽  
C. Bruggmann ◽  
F. Doffey-Lazeyras ◽  
C. Samer ◽  
J. Desmeules ◽  
...  
Keyword(s):  
Cell Line ◽  
In Vitro Evaluation ◽  
Heparg Cell ◽  
Heparg Cell Line

scholarly journals Critical selection of reliable reference genes for gene expression study in the HepaRG cell line

2011 ◽  
Vol 81 (10) ◽  
pp. 1255-1261 ◽  
Author(s):  
Liesbeth Ceelen ◽  
Ward De Spiegelaere ◽  
Michael David ◽  
Jurgen De Craene ◽  
Mathieu Vinken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Reference Genes ◽  
Gene Expression Study ◽  
Expression Study ◽  
Heparg Cell ◽  
Heparg Cell Line ◽  
Selection Of

The HepaRG cell line: a valuable in vitro tool for hepatitis virus infection studies

2013 ◽  
Vol 7 (2) ◽  
pp. 394-399
Author(s):  
Liesbeth Ceelen ◽  
Marusya Lieveld ◽  
Ramses Forsyth ◽  
Mathieu Vinken
Keyword(s):  
Virus Infection ◽  
Cell Line ◽  
Hepatitis Virus ◽  
Heparg Cell ◽  
Heparg Cell Line ◽  
Hepatitis Virus Infection
Sign in / Sign up

Export Citation Format

Share Document