scholarly journals Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese mice

2014 ◽  
Vol 164 (4) ◽  
pp. 259-269 ◽  
Author(s):  
Jason M. York ◽  
Karla J. Castellanos ◽  
Robert J. Cabay ◽  
Giamila Fantuzzi
Keyword(s):  
Acute Pancreatitis ◽  
Nucleotide Binding ◽  
Binding Domain ◽  
Obese Mice ◽  
Nucleotide Binding Domain ◽  
Pyrin Domain ◽  
Experimentally Induced

scholarly journals The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology

2017 ◽  
Vol 11 (2) ◽  
pp. 57-72 ◽  
Author(s):  
Brian M. Inouye ◽  
Francis M. Hughes,Jr ◽  
Stephanie J. Sexton ◽  
J. Todd Purves
Keyword(s):  
Outlet Obstruction ◽  
Nucleotide Binding ◽  
Binding Domain ◽  
Nucleotide Binding Domain ◽  
Pyrin Domain ◽  
Voiding Symptoms ◽  
Bladder Pathology ◽  
Tract Infections ◽  
Underlying Inflammation

Irritative voiding symptoms (e.g. increased frequency and urgency) occur in many common pathologic conditions such as urinary tract infections and bladder outlet obstruction, and these conditions are well-established to have underlying inflammation that directly triggers these symptoms. However, it remains unclear as to how such diverse stimuli individually generate a common inflammatory process. Jürg Tschopp provided substantial insight into this conundrum when, working with extracts from THP-1 cells, he reported the existence of the inflammasome. He described it as a structure that senses multiple diverse signals from intracellular/extracellular sources and pathogens and triggers inflammation by the maturation and release of the pro-inflammatory cytokines interleukin-1β and interleukin-18. Recently, many of these sensors were found in the bladder and the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3, has been shown to be a central mediator of inflammation in several urological diseases. In this review, we introduce the nucleotide-binding domain, leucine-rich-containing family, pyrin domaincontaining-3 inflammasome, highlight its emerging role in several common urologic conditions, and speculate on the potential involvement of other inflammasomes in bladder pathology.

scholarly journals A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases.

1983 ◽  
Vol 258 (10) ◽  
pp. 6450-6457 ◽  
Author(s):  
P Argos ◽  
M Hanei ◽  
J M Wilson ◽  
W N Kelley
Keyword(s):  
Nucleotide Binding ◽  
Binding Domain ◽  
Nucleotide Binding Domain
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