scholarly journals Vulvar squamous cell carcinoma associated with Equus caballus papillomavirus type 2 infection in a Japanese mare

2021 ◽  
Vol 12 ◽  
pp. 200226
Author(s):  
Nanako Yamashita-Kawanishi ◽  
Soma Ito ◽  
James K. Chambers ◽  
Kazuyuki Uchida ◽  
Masato Sato ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Equus Caballus ◽  
Vulvar Squamous Cell Carcinoma

scholarly journals Exploring Differentially Methylated Genes in Vulvar Squamous Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3580
Author(s):  
Shatavisha Dasgupta ◽  
Patricia C. Ewing-Graham ◽  
Sigrid M. A. Swagemakers ◽  
Thierry P. P. van den Bosch ◽  
Peggy N. Atmodimedjo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Sequences ◽  
Cpg Island ◽  
Epigenetic Modification ◽  
Vulvar Squamous Cell Carcinoma ◽  
Differentially Methylated Genes ◽  
Methylation Profiling

DNA methylation is the most widely studied mechanism of epigenetic modification, which can influence gene expression without alterations in DNA sequences. Aberrations in DNA methylation are known to play a role in carcinogenesis, and methylation profiling has enabled the identification of biomarkers of potential clinical interest for several cancers. For vulvar squamous cell carcinoma (VSCC), however, methylation profiling remains an under-studied area. We sought to identify differentially methylated genes (DMGs) in VSCC, by performing Infinium MethylationEPIC BeadChip (Illumina) array sequencing, on a set of primary VSCC (n = 18), and normal vulvar tissue from women with no history of vulvar (pre)malignancies (n = 6). Using a false-discovery rate of 0.05, beta-difference (Δβ) of ± 0.5, and CpG-island probes as cut-offs, 199 DMGs (195 hyper-methylated, 4 hypo-methylated) were identified for VSCC. Most of the hyper-methylated genes were found to be involved in transcription regulator activity, indicating that disruption of this process plays a vital role in VSCC development. The majority of VSCCs harbored amplifications of chromosomes 3, 8, and 9. We identified a set of DMGs in this exploratory, hypothesis-generating study, which we hope will facilitate epigenetic profiling of VSCCs. Prognostic relevance of these DMGs deserves further exploration in larger cohorts of VSCC and its precursor lesions.

scholarly journals Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeffrey A. How ◽  
Amir A. Jazaeri ◽  
Pamela T. Soliman ◽  
Nicole D. Fleming ◽  
Jing Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Phase Ii ◽  
Squamous Cell ◽  
Single Agent ◽  
Case Series ◽  
Predictive Biomarkers ◽  
Vulvar Squamous Cell Carcinoma ◽  
Metastatic Setting ◽  
Progression Of Disease

AbstractVaginal and vulvar squamous cell carcinoma (SCC) are rare tumors that can be challenging to treat in the recurrent or metastatic setting. We present a case series of patients with vaginal or vulvar SCC who were treated with single-agent pembrolizumab as part of a phase II basket clinical trial to evaluate efficacy and safety. Two cases of recurrent and metastatic vaginal SCC, with multiple prior lines of systemic chemotherapy and radiation, received pembrolizumab. One patient had significant reduction (81%) in target tumor lesions prior to treatment discontinuation at cycle 10 following confirmed progression of disease with new metastatic lesions (stable disease by irRECIST criteria). In contrast, the other patient with vaginal SCC discontinued treatment after cycle 3 due to disease progression. Both patients had PD-L1 positive vaginal tumors and tolerated treatment well. One case of recurrent vulvar SCC with multiple surgical resections and prior progression on systemic carboplatin had a 30% reduction in her target tumor lesions following pembrolizumab treatment with a PD-L1 positive tumor. Treatment was discontinued for grade 3 mucositis after cycle 5. Pembrolizumab may provide some clinical benefit to some patients with vaginal or vulvar SCC and is overall safe to utilize in this population. Future studies are needed to evaluate the efficacy of pembrolizumab in these rare tumor types and to identify predictive biomarkers of response.

scholarly journals The diagnostic challenge of vulvar squamous cell carcinoma: Clinical manifestations and unusual human papillomavirus types

2014 ◽  
Vol 70 (3) ◽  
pp. 586-588 ◽  
Author(s):  
Aditi Sagdeo ◽  
Rachel H. Gormley ◽  
Katrina Abuabara ◽  
Stephen K. Tyring ◽  
Peter Rady ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Manifestations ◽  
Vulvar Squamous Cell Carcinoma ◽  
Diagnostic Challenge

The role of RhoA in vulvar squamous cell carcinoma: a carcinogenesis, progression, and target therapy marker

Tumor Biology ◽  
2015 ◽  
Vol 37 (3) ◽  
pp. 2879-2890 ◽  
Author(s):  
Jing Wang ◽  
Qiong Wu ◽  
Li-hua Zhang ◽  
Yun-xia Zhao ◽  
Xin Wu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Target Therapy ◽  
Vulvar Squamous Cell Carcinoma

scholarly journals Genomic characterization of vulvar squamous cell carcinoma

2018 ◽  
Vol 29 ◽  
pp. viii349
Author(s):  
K. Prieske ◽  
M. Alawi ◽  
S.A. Joosse ◽  
K. Eylmann ◽  
E. Burandt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Vulvar Squamous Cell Carcinoma ◽  
Genomic Characterization

scholarly journals Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Emily R. Holthoff ◽  
Stephanie D. Byrum ◽  
Samuel G. Mackintosh ◽  
Thomas Kelly ◽  
Alan J. Tackett ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Differential Expression ◽  
Squamous Cell ◽  
Vulvar Squamous Cell Carcinoma

scholarly journals Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma

2013 ◽  
pp. 621
Author(s):  
Ali Yavuzcan ◽  
Pelin Özün Özbay ◽  
Ekinci ◽  
Yiğit ◽  
Uysal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Vulvar Squamous Cell Carcinoma
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