Intratubular Germ Cell Neoplasia of the Testis, Bilateral Testicular Cancer, and Aberrant Histologies

Purpose To evaluate the probability of subsequent testicular cancer (STC) in patients with intratubular germ cell neoplasia unclassified (IGCNU) treated for first-time invasive germ cell cancer. Patients and Methods Sixty-one patients with germ cell testicular cancer or extragonadal germ cell cancer received follow-up from diagnosis of IGCNU to development of STC, initiation of IGCNU-definitive treatment (orchiectomy/radiotherapy), emigration, death, or end of follow-up. The probability of STC was assessed in subgroups according to chemotherapy burden. Results The probability of STC in the nonexposed patients was significantly increased compared with those exposed to chemotherapy (P = .05; 5-year probability of 54% [95% CI, 33% to 78%] and 23% [95% CI, 11% to 45%], respectively). In the group of patients treated with one to three cycles or no chemotherapy, the probability of STC was significantly increased compared with those exposed to four or more cycles (P = .03; 5-year probability of 42% [95% CI, 27% to 62%] and 22% [95% CI, 8% to 54%], respectively). Twenty-two of 22 patients were tumor-free and alive at a median of 56 months (range, 2 to 184 months) after diagnosis of STC. Conclusion Platinum-based chemotherapy may reduce the probability of STC in patients with IGCNU, particularly in those treated with four or more cycles of chemotherapy. A watch-and-wait strategy for patients with IGCNU may be justified in selected patients with future plans for paternity.

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p53 Protein alterations in human testicular cancer including pre-invasive intratubular germ-cell neoplasia

International Journal of Cancer ◽

10.1002/ijc.2910490209 ◽

1991 ◽

Vol 49 (2) ◽

pp. 196-202 ◽

Cited By ~ 93

Author(s):

Ji??ina Bártkov´ ◽

Ji??í Bártek ◽

Ji??ina Lukáŝ ◽

Bo??ivoj Vojtêŝek ◽

Zdenka Staŝková ◽

...

Keyword(s):

Testicular Cancer ◽

Germ Cell ◽

P53 Protein ◽

Intratubular Germ Cell Neoplasia ◽

Protein Alterations

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OCT 4 immunohistochemistry in postpubertal cryptorchidism

Open Medicine ◽

10.2478/s11536-010-0074-x ◽

2011 ◽

Vol 6 (2) ◽

pp. 243-246

Author(s):

Ivan Krhen ◽

Tomislav Kulis ◽

Marijana Coric ◽

Nikola Knezevic ◽

Zvonimir Marekovic ◽

...

Keyword(s):

Testicular Cancer ◽

Germ Cell ◽

Immunohistochemical Staining ◽

Testicular Germ Cell Tumor ◽

Specific Marker ◽

Nuclear Staining ◽

Testicular Germ Cell ◽

Increased Risk ◽

Intratubular Germ Cell Neoplasia ◽

Work Up

AbstractPatients with cryptorchidism are at an increased risk for germ cell testicular cancer. OCT 4 has been shown to be a sensitive and specific marker for some types of germ cell testicular cancer. We undertook this study to establish whether OCT 4 immunohistochemistry is a useful tool in the pathohistologic evaluation of postpubertal patients with cryptorchidism. Seventeen postpubertal patients underwent orchidectomy for cryptorchidism at our center since 1997. Immunohistochemical staining with OCT 4 was performed on these samples. Characteristic OCT 4 nuclear staining was positive in two patients. One patient was correctly diagnosed on previous pathohistological evaluation, while OCT4 immunohistochemical staining revealed previously unidentified intratubular germ cell neoplasia in the other patient. OCT 4 immunohistochemistry can be useful in diagnosing a testicular germ cell tumor in patients with cryptorchidism. If we consider a low number of postpubertal patients with cryptorchidism a benefit of immunohistochemical staining with OCT4, this could favor the use of OCT 4 staining in work-up of cryptorchidism.

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