Characterization of Nuclear Matrix Protein Alterations Associated with Renal Cell Carcinoma

Urology ◽  
2007 ◽  
Vol 69 (6) ◽  
pp. 1227-1230 ◽  
Author(s):  
Glenn M. Cannon ◽  
Manimaalha Balasudramani ◽  
Robert H. Getzenberg
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Matrix ◽  
Renal Cell ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Protein Alterations

389: Characterization of Nuclear Matrix Protein Alterations Associated with Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 127-127
Author(s):  
M. Cannon ◽  
Manimaalha Balasudramani ◽  
Robert H. Getzenberg
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Matrix ◽  
Renal Cell ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Protein Alterations

IDENTIFICATION OF NUCLEAR MATRIX PROTEIN ALTERATIONS ASSOCIATED WITH RENAL CELL CARCINOMA

1998 ◽  
Vol 159 (4) ◽  
pp. 1359-1363 ◽  
Author(s):  
BADRINATH R. KONETY ◽  
AJAY K. NANGIA ◽  
THU-SUONG T. NGUYEN ◽  
BARBARA N. VEITMEIER ◽  
RAJIV DHIR ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Matrix ◽  
Renal Cell ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Protein Alterations

IDENTIFICATION OF NUCLEAR MATRIX PROTEIN ALTERATIONS ASSOCIATED WITH RENAL CELL CARCINOMA

1998 ◽  
pp. 1359-1363 ◽  
Author(s):  
BADRINATH R. KONETY ◽  
AJAY K. NANGIA ◽  
THU-SUONG T. NGUYEN ◽  
BARBARA N. VEITMEIER ◽  
RAJIV DHIR ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Matrix ◽  
Renal Cell ◽  
Matrix Protein ◽  
Nuclear Matrix Protein ◽  
Protein Alterations

1023: Using Nuclear Matrix Protein, RCCA-5, as Biomarker for Renal Cell Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 270-270 ◽  
Author(s):  
Joseph J. Chen ◽  
Robert H. Getzenberg
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Matrix ◽  
Renal Cell ◽  
Matrix Protein ◽  
Nuclear Matrix Protein

Urinary nuclear matrix protein 22 for diagnosis of renal cell carcinoma

2005 ◽  
Vol 39 (1) ◽  
pp. 25-29 ◽  
Author(s):  
K. Kaya ◽  
S. Ayan ◽  
G. Gokce ◽  
H. Kilicarslan ◽  
E. Yildiz ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Matrix ◽  
Renal Cell ◽  
Matrix Protein ◽  
Nuclear Matrix Protein

scholarly journals Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines

2021 ◽  
Author(s):  
Youfeng Yang ◽  
Christopher J. Ricketts ◽  
Cathy D. Vocke ◽  
J. Keith Killian ◽  
Hesed M. Padilla‐Nash ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell ◽  
Carcinoma Cell Lines

Characterization of FH-deficient renal cell carcinoma

2021 ◽  
Author(s):  
Louise Stone
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell

scholarly journals Development and characterization of a novel mAb against bilitranslocase - a new biomarker of renal carcinoma

2013 ◽  
Vol 47 (2) ◽  
pp. 128-137 ◽  
Author(s):  
Sendi Montanic ◽  
Michela Terdoslavich ◽  
Uros Rajcevic ◽  
Luigina De Leo ◽  
Serena Department of Medical Sciences, Uni ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Monoclonal Antibodies ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Carcinoma ◽  
Vascular Endothelial Cells ◽  
Polyclonal Antibodies ◽  
Functional Characterization ◽  
Immunological Approach

Background. Bilitranslocase (TC 2.A.65.1.1) is a bilirubin-specific membrane transporter, found on absorptive (stomach and intestine) and excretory (kidney and liver) epithelia and in vascular endothelium. Polyclonal antibodies have been raised in rabbits in the past, using a synthetic peptide corresponding to AA65-77 of rat liver bilitranslocase, as an antigen. Affinity-purified antibodies from immune sera have been found to inhibit various membrane transport functions, including the bilirubin uptake into human hepatocytes and the uptake of some flavonoids into human vascular endothelial cells. It was described by means of immunohistochemistry using polyclonal antibodies that bilitranslocase expression is severely down-regulated in clear cell renal carcinoma. The aim of our work was development and characterization of high-affinity, specific mAbs against bilitranslocase, which can be used as a potential diagnostic tool in renal cell carcinoma as well as in a wide variety of biological assays on different human tissues. Materials and methods. Mice were immunized with a multi-antigen peptide corresponding to segment 65-75 of predicted primary structure of the bilitranslocase protein. By a sequence of cloning, immune- and functional tests, we aimed at obtaining a specific monoclonal antibody which recognizes a 37 kDa membrane protein, and influences the transport activity of bilitranslocase. Results. On the basis of previous results, specific IgM monoclonal antibodies were produced in BALB/c mice, in order to further improve and extend the immunological approach to the study of bilitranslocase in renal cancer cells as well as to develop its potential diagnostics use. Conclusions. In this article we show an immunological approach, based on newly developed monoclonal antibodies, to a detailed biochemical and functional characterization of a protein whose gene and protein structure is still unknown. We were able to demonstrate our novel mAb as a tumor marker candidate of renal cell carcinoma, which may prove useful in the diagnostic procedures.

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