Comparison of White Light, Photodynamic Diagnosis, and Narrow-band Imaging in Detection of Carcinoma In Situ or Flat Dysplasia at Transurethral Resection of the Bladder: the DaBlaCa-8 Study

Urology ◽  
2017 ◽  
Vol 102 ◽  
pp. 138-142 ◽  
Author(s):  
Ditte Drejer ◽  
Sami Béji ◽  
Recep Oezeke ◽  
Anna Munk Nielsen ◽  
Søren Høyer ◽  
...  
Keyword(s):  
White Light ◽  
Transurethral Resection ◽  
Carcinoma In Situ ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Photodynamic Diagnosis

scholarly journals Comparison Between 5-Aminolevulinic Acid Photodynamic Diagnosis and Narrow- Band Imaging for Bladder Cancer Detection: A Single-Center Retrospective Cohort Study

2021 ◽  
Author(s):  
Hiroki Hagimoto ◽  
Noriyuki Makita ◽  
Yuta Mine ◽  
Hidetoshi Kokubun ◽  
Shiori Murata ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Detection ◽  
White Light ◽  
Transurethral Resection ◽  
Aminolevulinic Acid ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Photodynamic Diagnosis ◽  
Bladder Tumors

Abstract BackgroundNo comparative studies exist between 5-aminolevulinic acid-photodynamic diagnosis (PDD) and narrow-band imaging (NBI) for the detection of urothelial carcinoma. Therefore, we compared 5-aminolevulinic acid-mediated PDD with NBI for cancer detection during transurethral resection of bladder tumors.MethodsBetween June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-aminolevulinic acid (20 mg/kg) 2 h before transurethral resection of bladder tumors. The bladder was inspected with white light, PDD, and NBI for each patient and all areas that were positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results.ResultsThe sensitivity, specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 88.1%, 47.5%, 80.9%, and 61.3% for white light; 89.6%, 22.5%, 74.5%, and 46.2% for PDD; and 76.2%, 46.3%, 78.2%, and 43.5% for NBI, respectively. PPD was significantly more sensitive than NBI for all lesions (p<0.001), including carcinoma in situ lesions (94.6% vs. 54.1%, p<0.001).ConclusionsPDD can increase the detection rate of bladder cancer compared to NBI by greater than 10%. Adding PDD to white light can detect 100% of carcinoma in situ lesions.

scholarly journals Usefulness of narrow-band imaging in transurethral resection of bladder tumor: Early experience from a tertiary center in India

2019 ◽  
Vol 08 (04) ◽  
pp. 226-228
Author(s):  
Kanuj Malik ◽  
Anand Raja ◽  
Sivakumar Mahalingam ◽  
L.S Ravishankar
Keyword(s):  
White Light ◽  
Transurethral Resection ◽  
Bladder Tumor ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Urinary Bladder Cancer ◽  
Early Experience ◽  
Current Standard ◽  
Tertiary Center ◽  
Long Term Follow Up

Abstract Background: The current standard for diagnosis and treatment of urinary bladder cancer is transurethral resection of bladder tumor (TURBT) using white light guidance. Narrow band imaging (NBI) has emerged as a promising method for identifying additional bladder lesions. Various studies have been published to evaluate its sensitivity in identifying new lesions and its impact on decreasing recurrences. In this study, we evaluated our early experience using NBI in TURBTs. Aims and Objective: The aim of the study is to determine the accuracy of NBI in identifying additional malignant lesions during TURBT. Materials and Methods: We retrospectively collected data for all patients who underwent either TURBT or repeat TURBT with white light and NBI from November 2016 to July 2017 at Cancer Institute (WIA). The number of additional lesions identified using NBI was evaluated along with its correlation with the final histopathology. Results: Forty patients were analysed of which 20 underwent TURBT and 20 underwent repeat TURBT. Of these, 36 patients had complete resection of tumour. Additional lesions were detected in 6 patients (14%) by NBI of which 2 (33%) were malignant histology. The additional lesions detected were carcinoma in situ and no patient was upstaged. Conclusion: The inclusion of NBI to conventional white light TURBT increases the sensitivity for identifying additional lesions. The limitation of NBI is high false positivity and its availability. Long term follow up studies with larger subset of patients are required to evaluate its role in decreasing recurrences and justification in routine clinical practice.

scholarly journals Performance of Narrow Band Imaging (NBI) and Photodynamic Diagnosis (PDD) Fluorescence Imaging Compared to White Light Cystoscopy (WLC) in Detecting Non-Muscle Invasive Bladder Cancer: A Systematic Review and Lesion-Level Diagnostic Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4378
Author(s):  
Giorgio I. Russo ◽  
Tamir N. Sholklapper ◽  
Andrea Cocci ◽  
Giuseppe Broggi ◽  
Rosario Caltabiano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bladder Cancer ◽  
White Light ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Meta Analysis ◽  
Photodynamic Diagnosis ◽  
Muscle Invasive Bladder Cancer ◽  
White Light Cystoscopy ◽  
Muscle Invasive

Despite early detection and regular surveillance of non-muscle invasive bladder cancer (NMIBC), recurrence and progression rates remain exceedingly high for this highly prevalent malignancy. Limited visualization of malignant lesions with standard cystoscopy and associated false-negative biopsy rates have been the driving force for investigating alternative and adjunctive technologies for improved cystoscopy. The aim of our systematic review and meta-analysis was to compare the sensitivity, specificity, and oncologic outcomes of photodynamic diagnosis (PDD) fluorescence, narrow band imaging (NBI), and conventional white light cystoscopy (WLC) in detecting NMIBC. Out of 1,087 studies reviewed, 17 prospective non-randomized and randomized controlled trials met inclusion criteria for the study. We demonstrated that tumor resection with either PDD and NBI exhibited lower recurrence rates and greater diagnostic sensitivity compared to WLC alone. NBI demonstrated superior disease sensitivity and specificity as compared to WLC and an overall greater hierarchical summary receiver operative characteristic. Our findings are consistent with emerging guidelines and underscore the value of integrating these enhanced technologies as a part of the standard care for patients with suspected or confirmed NMIBC.

Diagnostic significance of narrow-band imaging for detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral leukoplakia

2012 ◽  
Vol 122 (12) ◽  
pp. 2754-2761 ◽  
Author(s):  
Shih-Wei Yang ◽  
Yun-Shien Lee ◽  
Liang-Che Chang ◽  
Cheng-Cheng Hwang ◽  
Tai-An Chen
Keyword(s):  
Carcinoma In Situ ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Oral Leukoplakia ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Diagnostic Significance

Moderne endoskopische Bildgebungsverfahren für das Urothelkarzinom der Harnblase

2017 ◽  
Vol 48 (04) ◽  
pp. 296-305 ◽  
Author(s):  
M. Kriegmair ◽  
M. Ritter ◽  
M. Michel ◽  
C. Bolenz
Keyword(s):  
Carcinoma In Situ ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Optische Kohärenztomografie ◽  
Diagnostik Und Therapie ◽  
Molekulare Zielstrukturen ◽  
Eine Verbesserte

ZusammenfassungDie primäre Diagnostik und Therapie des Urothelkarzinoms (UCC) der Harnblase erfolgt endoskopisch. Eine möglichst sichere Differenzierung zwischen benignen Läsionen und maligne entartetem Urothel ist erforderlich. Die Weißlichtzystoskopie gilt als Goldstandard, jedoch bestehen Limitationen bei der Detektion kleiner Tumore und des Carcinoma in situ. Mit der Photodyamischen Diagnostik (PDD) und dem Narrow Band Imaging (NBI) stehen zwei klinisch etablierte Techniken zur Verfügung, die die Detektionsrate verbessern und die Rezidivrate eines Urothelkarzinoms senken können. Das Storz Professional Imaging Enhancement System (SPIES) beruht auf einer digitalen Kontrastverstärkung und wird aktuell in klinischen Studien evaluiert. Mit der konfokalen Laser-Endomikroskopie (CLE) wird das Prinzip der optischen Biopsie verfolgt. Sie erlaubt bereits intraoperativ die Darstellung des Gewebes mit einer der Lichtmikroskopie vergleichbaren Auflösung. Die optische Kohärenztomografie (OCT) stellt intraoperativ Querschnittsbilder der Harnblasenwand dar und liefert Informationen zur Eindringtiefe des Tumors. Eine weitere Ergänzung ist die Raman-Spektroskopie, die über Spektralanalysen die Beurteilung der Zusammensetzung von Material und Gewebe erlaubt. Die zunehmende molekulare Entschlüsselung des Urothelkarzinoms der Harnblase bietet neue Chancen für die Endoskopie. In Zukunft werden moderne Fotosensibilisatoren über molekulare Zielstrukturen spezifisch an Urothelkarzinomzellen binden, um malignes Gewebe sensitiver zu detektieren. Softwarebasierte Bildgebungsmodalitäten bieten neben der Unterstützung bei der Interpretation von endoskopischen Bildern diverse Möglichkeiten für eine verbesserte digitale Befunddokumentation und -kommunikation. Die vorliegende Arbeit stellt die modernen endoskopischen Bildgebungsverfahren vor und diskutiert deren potenziellen klinischen Nutzen.

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