scholarly journals Comparison Between 5-Aminolevulinic Acid Photodynamic Diagnosis and Narrow- Band Imaging for Bladder Cancer Detection: A Single-Center Retrospective Cohort Study

2021 ◽  
Author(s):  
Hiroki Hagimoto ◽  
Noriyuki Makita ◽  
Yuta Mine ◽  
Hidetoshi Kokubun ◽  
Shiori Murata ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Detection ◽  
White Light ◽  
Transurethral Resection ◽  
Aminolevulinic Acid ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Photodynamic Diagnosis ◽  
Bladder Tumors

Abstract BackgroundNo comparative studies exist between 5-aminolevulinic acid-photodynamic diagnosis (PDD) and narrow-band imaging (NBI) for the detection of urothelial carcinoma. Therefore, we compared 5-aminolevulinic acid-mediated PDD with NBI for cancer detection during transurethral resection of bladder tumors.MethodsBetween June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-aminolevulinic acid (20 mg/kg) 2 h before transurethral resection of bladder tumors. The bladder was inspected with white light, PDD, and NBI for each patient and all areas that were positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results.ResultsThe sensitivity, specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 88.1%, 47.5%, 80.9%, and 61.3% for white light; 89.6%, 22.5%, 74.5%, and 46.2% for PDD; and 76.2%, 46.3%, 78.2%, and 43.5% for NBI, respectively. PPD was significantly more sensitive than NBI for all lesions (p<0.001), including carcinoma in situ lesions (94.6% vs. 54.1%, p<0.001).ConclusionsPDD can increase the detection rate of bladder cancer compared to NBI by greater than 10%. Adding PDD to white light can detect 100% of carcinoma in situ lesions.

scholarly journals Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroki Hagimoto ◽  
Noriyuki Makita ◽  
Yuta Mine ◽  
Hidetoshi Kokubun ◽  
Shiori Murata ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urothelial Carcinoma ◽  
Cancer Detection ◽  
Predictive Value ◽  
Aminolevulinic Acid ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Bladder Tumour ◽  
Photodynamic Diagnosis ◽  
Imaging Data

Abstract Background To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT). Methods Between June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The bladder was inspected with white light (WL), PDD, and NBI for each patient, and all areas positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results. Results The sensitivities of WL, PDD, and NBI for detecting urothelial carcinoma were 88.1%, 89.6%, and 76.2%, respectively. The specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 47.5%, 80.9%, and 61.3%, respectively, for WL; 22.5%, 74.5%, and 46.2%, respectively, for PDD; and 46.3%, 78.2%, and 43.5%, respectively, for NBI. PDD was significantly more sensitive than NBI for all lesions (p < 0.001) and carcinoma in situ (CIS) lesions (94.6% vs. 54.1%, p < 0.001). Conclusions PDD can increase the detection rate of bladder cancer, compared to NBI, by greater than 10%. Therefore, 100% of CIS lesions can be detected by adding PDD to WL.

scholarly journals Performance of Narrow Band Imaging (NBI) and Photodynamic Diagnosis (PDD) Fluorescence Imaging Compared to White Light Cystoscopy (WLC) in Detecting Non-Muscle Invasive Bladder Cancer: A Systematic Review and Lesion-Level Diagnostic Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4378
Author(s):  
Giorgio I. Russo ◽  
Tamir N. Sholklapper ◽  
Andrea Cocci ◽  
Giuseppe Broggi ◽  
Rosario Caltabiano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bladder Cancer ◽  
White Light ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Meta Analysis ◽  
Photodynamic Diagnosis ◽  
Muscle Invasive Bladder Cancer ◽  
White Light Cystoscopy ◽  
Muscle Invasive

Despite early detection and regular surveillance of non-muscle invasive bladder cancer (NMIBC), recurrence and progression rates remain exceedingly high for this highly prevalent malignancy. Limited visualization of malignant lesions with standard cystoscopy and associated false-negative biopsy rates have been the driving force for investigating alternative and adjunctive technologies for improved cystoscopy. The aim of our systematic review and meta-analysis was to compare the sensitivity, specificity, and oncologic outcomes of photodynamic diagnosis (PDD) fluorescence, narrow band imaging (NBI), and conventional white light cystoscopy (WLC) in detecting NMIBC. Out of 1,087 studies reviewed, 17 prospective non-randomized and randomized controlled trials met inclusion criteria for the study. We demonstrated that tumor resection with either PDD and NBI exhibited lower recurrence rates and greater diagnostic sensitivity compared to WLC alone. NBI demonstrated superior disease sensitivity and specificity as compared to WLC and an overall greater hierarchical summary receiver operative characteristic. Our findings are consistent with emerging guidelines and underscore the value of integrating these enhanced technologies as a part of the standard care for patients with suspected or confirmed NMIBC.

scholarly journals Emerging Endoscopic and Photodynamic Techniques for Bladder Cancer Detection and Surveillance

2011 ◽  
Vol 11 ◽  
pp. 2550-2558 ◽  
Author(s):  
Prashant Patel ◽  
Richard T. Bryan ◽  
D. Michael A. Wallace
Keyword(s):  
Raman Spectroscopy ◽  
Bladder Cancer ◽  
Cancer Detection ◽  
Clinical Evidence ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Photodynamic Diagnosis ◽  
Virtual Cystoscopy ◽  
Spectroscopy Optical ◽  
Bladder Tumours

This review provides an overview of emerging techniques, namely, photodynamic diagnosis (PDD), narrow band imaging (NBI), Raman spectroscopy, optical coherence tomography, virtual cystoscopy, and endoscopic microscopy for its use in the diagnosis and surveillance of bladder cancer. The technology, clinical evidence and future applications of these approaches are discussed with particular emphasis on PDD and NBI. These approaches show promise to optimise cystoscopy and transurethral resection of bladder tumours.

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