scholarly journals Avian reovirus sigma C enhances the mucosal and systemic immune responses elicited by antigen-conjugated lactic acid bacteria

Vaccine ◽  
2012 ◽  
Vol 30 (33) ◽  
pp. 5019-5029 ◽  
Author(s):  
Kuan-Hsun Lin ◽  
Ai-Ping Hsu ◽  
Jui-Hung Shien ◽  
Tien-Jye Chang ◽  
Jiunn-Wang Liao ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Immune Responses ◽  
Avian Reovirus

Differential effects of lactobacilli on activation and maturation of mouse dendritic cells

2014 ◽  
Vol 5 (3) ◽  
pp. 323-334 ◽  
Author(s):  
I. Elawadli ◽  
J.T. Brisbin ◽  
B.A. Mallard ◽  
M.W. Griffiths ◽  
M. Corredig ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Immune Responses ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Lactobacillus Helveticus ◽  
Inflammatory Cytokine Production

Lactic acid bacteria (LAB) are of interest because of their potential to modulate immune responses. The effects of LAB range from regulation to stimulation of the immune system. A series of studies were performed in vitro to study the effects of six lactic acid bacteria (LAB), Lactobacillus helveticus LH-2, Lactobacillus acidophilus La-5, La-115, La-116 and La-14, and Lactobacillus salivarius, on maturation and activation of mouse dendritic cells. Production of tumour necrosis factor (TNF)-?, interleukin (IL)-6 and IL-10 by dendritic cells (DCs) was determined after treating cells with live LAB. The expression of DC maturation markers, CD80 and CD40, was also measured using flow cytometry after stimulation with LAB. In addition, the expression of Toll-like receptors (TLRs) 2, 4 and 9 by DCs stimulated with LAB was measured. Our results revealed that LAB act differentially on pro-inflammatory and anti-inflammatory cytokine production and induction of co-stimulatory molecules by DCs. Specifically, L. salivarius was found to be the most effective LAB to induce pro-inflammatory cytokine production and expression of co-stimulatory molecules. Moreover, La-14, La-116 and La-5 induced moderate maturation and activation of DCs. On the other hand, LH-2 and La-115 were the least effective lactobacilli to induce DC responses. The present study also revealed that L. salivarius was able to induce the expression of TLR2, 4 and 9 by DCs. In conclusion, various strains and species of LAB can differentially regulate DC activation and maturation, providing further evidence that these bacteria may have the ability to influence and steer immune responses in vivo.

scholarly journals Intravaginal Lactic Acid Bacteria Modulated Local and Systemic Immune Responses and Lowered the Incidence of Uterine Infections in Periparturient Dairy Cows

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124167 ◽  
Author(s):  
Qilan Deng ◽  
John F. Odhiambo ◽  
Umar Farooq ◽  
Tran Lam ◽  
Suzanna M. Dunn ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Immune Responses ◽  
Dairy Cows

Modulation of peanut-induced allergic immune responses by oral lactic acid bacteria-based vaccines in mice

2014 ◽  
Vol 98 (14) ◽  
pp. 6353-6364 ◽  
Author(s):  
Chengcheng Ren ◽  
Qiuxiang Zhang ◽  
Gang Wang ◽  
Chunqing Ai ◽  
Mengsha Hu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Immune Responses

scholarly journals Lactic acid bacteria, probiotics and immune system

2012 ◽  
Vol 47 (No. 6) ◽  
pp. 169-180 ◽  
Author(s):  
R. Herich ◽  
M. Levkut
Keyword(s):  
Lactic Acid ◽  
Immune System ◽  
Lactic Acid Bacteria ◽  
Immune Responses ◽  
The Body ◽  
Secretory Iga ◽  
Defence Mechanisms ◽  
Effective Protection ◽  
Mucous Membranes ◽  
Micro Organisms

Mucous membranes of the body are in direct contact with the outside environment and they are colonised by a large number of different bacteria. Through mucous membranes, the organism is in permanent con-tact with different antigens. Mucous surfaces are protected by many defence mechanisms that ensure a permanent and effective protection. They include the production of secretory IgA, the production of mucus, cytoprotective peptides, defensins etc. Indigenous microflora markedly affects the structure of the host mucous, its function, and the development of the whole immune system. Protective microflora prevents pathogens from adhering by competi-tion for substrates and places of adhesion, and they simultaneously produce antibacterial substances and stimulate the production of specific antibodies and mucus. The early colonisation of the gut with living micro-organisms is important for the development of the gut protection barrier. The number of immune and epithelial cells increases. Probiotic micro-organisms including lactic acid bacteria (LAB) positively influence the composition of the gut microflora; they stimulate the production of secretory IgA; they affect the targeted transportation of the luminal antigens to Peyer’s patches and they increase the production of IFN-g. LAB stimulate the activity of non-specific and specific immune cells. These properties of the LAB depend on the particular species or strain of bacteria. These singularities are probably determined by differences in the cell wall composition. LAB belong to a group of benefi-cially acting bacteria and they are able to eliminate damage to the gut microenvironment; they stimulate local and systemic immune responses and they maintain the integrity of the gut wall.

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