scholarly journals Using an effective TB vaccination regimen to identify immune responses associated with protection in the murine model

Vaccine ◽  
2021 ◽  
Vol 39 (9) ◽  
pp. 1452-1462
Author(s):  
Nawamin Pinpathomrat ◽  
Naomi Bull ◽  
Janet Pasricha ◽  
Rachel Harrington-Kandt ◽  
Helen McShane ◽  
...  
Keyword(s):  
Immune Responses ◽  
Murine Model ◽  
Vaccination Regimen

scholarly journals Viremia in Equine Herpes Virus-1 infection and a possible link to Transient Protective Immunity

2021 ◽  
Vol 9 (1) ◽  
pp. 11-16
Author(s):  
AR Awan ◽  
OL Tulp ◽  
HJ Field
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Murine Model ◽  
Herpes Virus ◽  
Natural Infection ◽  
Fluorescent Antibody ◽  
Buffy Coat ◽  
Effective Vaccine ◽  
Infection Model ◽  
Herpès Virus

Equine herpes virus (EHV-1) causes respiratory infections in equine, and results in abortion, paresis, neonatal death, and retinopathy and the virus may become latent following initial infection. Virus entry is via the respiratory route, and the virus replicates in the host in ciliated and non-ciliated epithelial cells of the respiratory tract and in Type 1 and Type 2 pneumocytes in the lung parenchyma. After viral replication in the respiratory system, the virus can become disseminated to other parts of body via viraemic cells. The virus also can cross the placenta which leads to abortion of live or dead fetuses without premonitory signs. Infected horses show transient immunity after natural or experimental infection and immune responses to EHV-1, but the immunoprotective status begins to decline after a few months of active infection. Due to the transient immune response, recovered horses are not immunoprotected and thus are prone to subsequent re-infection. Immunity is not long lived after experimental or natural infection, and as a result the development of an effective vaccine has remained a challenge. In this study viraemic cells were studied in a murine EHV-1 infection model. Mice were infected intranasally and viraemic cells were studied on days three and five which occurs during the peak of the infection. The results of this study may help to identify the nature of viraemic cells and their role in the transient immune response to infection. Buffy coat cells and lungs were removed and stained with a fluorescent antibody test for EHV-1 antigen, and lung specimens were subjected to transmission electron microscopy. Both techniques confirmed the presence of viraemic cells in lung tissues. These viraemic cells were further stained for EHV-1 antigen, and for CD4 or CD8 biomarkers and results are discussed re: pathogenesis of EHV-1 infection, identification of viraemic cells in a murine model and possible link of viraemia to transient immune responses in EHV-1 infection, which demonstrate the validity of this murine model for the investigation of the cytopathologic mechanism and sequelae of EHV manifestation in this model.

scholarly journals Experimental vaccine induces Th1-driven immune responses and resistance to Neisseria gonorrhoeae infection in a murine model

2017 ◽  
Vol 10 (6) ◽  
pp. 1594-1608 ◽  
Author(s):  
Y Liu ◽  
L A Hammer ◽  
W Liu ◽  
M M Hobbs ◽  
R A Zielke ◽  
...  
Keyword(s):  
Immune Responses ◽  
Neisseria Gonorrhoeae ◽  
Murine Model

A crucial role of macrophages in the immune responses to oral DNA vaccination against hepatitis B virus in a murine model

Vaccine ◽  
2001 ◽  
Vol 20 (1-2) ◽  
pp. 140-147 ◽  
Author(s):  
Bo-jian Zheng ◽  
Patrick C.Y Woo ◽  
Mun-hon Ng ◽  
Hoi-wah Tsoi ◽  
Lei-po Wong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Murine Model ◽  
Crucial Role ◽  
Dna Vaccination ◽  
B Virus

Abstract 2754: Inhibition of nitric oxide synthase and cyclooxygenase potentiate immune responses that control aggressive mammary tumor in a murine model

2020 ◽  
Author(s):  
Veena Somasundaram ◽  
Debashree Basudhar ◽  
Christopher McGinity ◽  
Robert Y. Cheng ◽  
Lisa A. Ridnour ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Immune Responses ◽  
Mammary Tumor ◽  
Murine Model ◽  
Oxide Synthase

scholarly journals Lack of Galectin-3 Prevents Cardiac Fibrosis and Effective Immune Responses in a Murine Model ofTrypanosoma cruziInfection

2015 ◽  
Vol 212 (7) ◽  
pp. 1160-1171 ◽  
Author(s):  
Miguel A. Pineda ◽  
Henar Cuervo ◽  
Manuel Fresno ◽  
Manuel Soto ◽  
Pedro Bonay
Keyword(s):  
Immune Responses ◽  
Murine Model ◽  
Cardiac Fibrosis ◽  
Galectin 3

Long-term exposure to gaseous formaldehyde promotes allergen-specific IgE-mediated immune responses in a murine model

2008 ◽  
Vol 27 (1) ◽  
pp. 37-43 ◽  
Author(s):  
YH Gu ◽  
Y Fujimiya ◽  
N Kunugita
Keyword(s):  
Immune Responses ◽  
Murine Model ◽  
Inflammatory Responses ◽  
Killer Cell ◽  
Cell Activity ◽  
Specific Ige ◽  
World Health ◽  
Indoor Environments ◽  
Allergic Symptoms ◽  
Ige Mediated

It has long been questioned that whether exposure to formaldehyde in indoor environments may be a risk factor for developing allergen-specific IgE-mediated inflammatory responses, because there is limited clinical or experimental evidence that formaldehyde is involved in the cascade for IgE production. There is no known lower limit, below which there is no threat of serious allergic symptoms. The present study illustrates that the threshold limit of formaldehyde, 0.08 ppm (as defined by the World Health Organization), did not cause ovalbumin-specific IgE inflammatory immune responses, but higher than threshold concentrations of formaldehyde gas result in both enhanced allergen-specific IgE responses and NK (Natural Killer)-cell activity in peripheral blood cells in a murine model. Thus, formaldehyde gas may be involved in promoting allergic inflammatory effects in subjects primed with specific allergens by NK-cell activation. These results indicate that even threshold concentrations of formaldehyde gas may play a regulatory role for ‘systemic’ cell-mediated immune responses. The extensive use of adhesives for building materials has resulted in higher levels of indoor air pollutants. It is conceivable that increased time indoors may enhance pre-existing allergic symptoms by concomitant exposure to volatile organic compounds and formaldehyde. The affordable limit for formaldehyde might be much lower than currently established levels in indoor environments.

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