Protective response mediated by immunization with recombinant proteins in a murine model of toxocariasis and canine infection by Toxocara canis

Vaccine ◽  
2022 ◽  
Author(s):  
Dumar Alexander Jaramillo-Hernández ◽  
Luis Fabián Salazar Garcés ◽  
Luis Gustavo Carvalho Pacheco ◽  
Carina Silva Pinheiro ◽  
Neuza Maria Alcantara-Neves
Keyword(s):  
Recombinant Proteins ◽  
Murine Model ◽  
Toxocara Canis ◽  
Protective Response ◽  
Canine Infection

Immunogenicity and protective response induced by recombinant Brucella abortus proteins Adk, SecB and combination of these two recombinant proteins against a virulent strain B. abortus 544 infection in BALB/c mice

2020 ◽  
Vol 143 ◽  
pp. 104137 ◽  
Author(s):  
Tran Xuan Ngoc Huy ◽  
Alisha Wehdnesday Bernardo Reyes ◽  
Son Hai Vu ◽  
Lauren Togonon Arayan ◽  
Huynh Tan Hop ◽  
...  
Keyword(s):  
Recombinant Proteins ◽  
Brucella Abortus ◽  
Virulent Strain ◽  
Protective Response

scholarly journals Immunoregulatory Effects of Somatic Extract of Toxocara canis on Airway Inflammations in Murine Model

2020 ◽  
Author(s):  
Milad BADRI ◽  
Fatemeh GHAFFARIFAR ◽  
Zuhair M. HASSAN ◽  
Abdolhossein DALIMI ◽  
Hélder CORTES
Keyword(s):  
Murine Model ◽  
Lavage Fluid ◽  
Toxocara Canis ◽  
Inhibitory Effect ◽  
Cell Number ◽  
Control Group ◽  
Tnf Α ◽  
Isolated Lung ◽  
Somatic Extract

Background: The immunomodulatory role of many parasites is well-documented. The current study designed to assess the immunoregulatory effects of the somatic extract (SE) of Toxocara canis on murine model of airway inflammations. Methods: The experiment was performed in department of parasitology of Tarbiat Modares University, Tehran, Iran from November 2018 to May 2019. Totally 30 female BALB/c mice divided into one control group and two experimental groups (10 mice in each group). The ovalbumin (OVA) group was sensitized with OVA in alum, while the SE group was administered with SE and OVA in alum intraperitoneally. The control group was injected with PBS in alum. Then, SE and OVA groups were intranasally challenged with OVA for three consecutive days and the control group encountered with PBS at the same time. One day after the last challenge, real-time PCR and histopathology survey were conducted on isolated lung tissues. Results: The gene expression of IL-25, IL-33, TNF-α and TLR-4 in SE group was significantly lower than OVA group (P<0.05). The level of IL-10, TGF-β and IFN-γ were considerably higher than the OVA group (P<0.05). The inflammation was reduced in SE group, as the total cell number of bronchoalveolar lavage fluid was less than OVA group. Based on the histopathology findings the inflammation was decreased in SE group compared to the OVA group. Conclusion: Although, an inhibitory effect of SE of T. canis on airway inflammations was detected, there is still a long way ahead regarding the indication of the precise mechanisms.

Immunogenicity and protection induced by recombinant Toxocara canis proteins in a murine model of toxocariasis

Vaccine ◽  
2020 ◽  
Vol 38 (30) ◽  
pp. 4762-4772
Author(s):  
Luis Fabián Salazar Garcés ◽  
Leonardo Freire Santiago ◽  
Sara Patrícia de Oliveira Santos ◽  
Dumar Alexander Jaramillo Hernández ◽  
Marcia Barbosa da Silva ◽  
...  
Keyword(s):  
Murine Model ◽  
Toxocara Canis

Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: New insights into the pathophysiology of an old infection

2018 ◽  
Vol 252 ◽  
pp. 173-179 ◽  
Author(s):  
Víctor Hugo Del Río-Araiza ◽  
Karen Elizabeth Nava-Castro ◽  
Fernando Alba-Hurtado ◽  
Andrés Quintanar-Stephano ◽  
Marco Antonio Muñoz-Guzmán ◽  
...  
Keyword(s):  
Murine Model ◽  
Toxocara Canis

Development of a highly sensitive IgG-ELISA based on recombinant arginine kinase of Toxocara canis for serodiagnosis of visceral larva migrans in the murine model

2008 ◽  
Vol 103 (4) ◽  
pp. 853-858 ◽  
Author(s):  
Susiji Wickramasinghe ◽  
Lalani Yatawara ◽  
Mitsuru Nagataki ◽  
Misa Takamoto ◽  
Yoshiya Watanabe ◽  
...  
Keyword(s):  
Murine Model ◽  
Arginine Kinase ◽  
Toxocara Canis ◽  
Larva Migrans ◽  
Visceral Larva Migrans ◽  
Highly Sensitive

Anti-OX40ligand treatment as a novel therapeutic strategy in a murine model of colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A685-A685
Author(s):  
B SINGH ◽  
V MALMSTROM ◽  
F POWRIE
Keyword(s):  
Murine Model ◽  
Therapeutic Strategy ◽  
Novel Therapeutic

404: Immune Mediated Survival Advantage and Primary Tumor Control of Cryoablation Compared to Nephrectomy in a Murine Model of Advanced Renal Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132 ◽  
Author(s):  
Sean P. Hedican ◽  
Eric R. Wilkinson ◽  
Thomas F. Warner ◽  
Fred T. Lee ◽  
Stephen Y. Nakada
Keyword(s):  
Renal Cancer ◽  
Murine Model ◽  
Primary Tumor ◽  
Survival Advantage ◽  
Tumor Control ◽  
Advanced Renal Cancer ◽  
Immune Mediated
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