Molecular characterization of Staphylococcus intermedius carriage by healthy dogs and comparison of antimicrobial susceptibility patterns to isolates from dogs with pyoderma

2005 ◽  
Vol 108 (1-2) ◽  
pp. 119-131 ◽  
Author(s):  
Faye A. Hartmann ◽  
David G. White ◽  
Susan E.H. West ◽  
Robert D. Walker ◽  
Douglas J. DeBoer
2015 ◽  
Vol 53 (6) ◽  
pp. 1806-1811 ◽  
Author(s):  
Giorgia Valsesia ◽  
Michael Hombach ◽  
Florian P. Maurer ◽  
Patrice Courvalin ◽  
Malgorzata Roos ◽  
...  

This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-typeEscherichia colipopulations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation ofin vitroAST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.


2002 ◽  
Vol 38 (5) ◽  
pp. 407-413 ◽  
Author(s):  
Annette D. Petersen ◽  
Robert D. Walker ◽  
Mark M. Bowman ◽  
Harold C. Schott ◽  
Edmund J. Rosser

Staphylococcus intermedius (S. intermedius) was isolated from 88.6% and 49.4% of skin and ear samples, respectively, during the years 1992 through 1997, and frequency of isolation remained unchanged. More than 95% of all S. intermedius isolates were susceptible to cephalothin and oxacillin, providing support for empirical treatment of canine skin and ear infections with cephalexin. Pseudomonas aeruginosa (P. aeruginosa) was isolated from 7.5% and 27.8% of skin and ear samples, respectively. The frequency of isolation from skin samples increased over the study period. Because of multidrug-resistant profiles for P. aeruginosa isolates, especially for ear isolates, empirical treatment of P. aeruginosa infections is not advisable.


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