Leishmania infantum nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) B-domain: Antibody antiproliferative effect on the promastigotes and IgG subclass responses in canine visceral leishmaniasis

2019 ◽  
Vol 271 ◽  
pp. 38-44
Author(s):  
Ana Carolina Ribeiro Gomes Maia ◽  
Gabriane Nascimento Porcino ◽  
Priscila Faria-Pinto ◽  
Túlio Vieira Mendes ◽  
Luciana Maria Ribeiro Antinarelli ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Infantum ◽  
Antiproliferative Effect ◽  
Nucleoside Triphosphate ◽  
Igg Subclass ◽  
Canine Visceral Leishmaniasis ◽  
Nucleoside Triphosphate Diphosphohydrolase ◽  
Domain Antibody

scholarly journals Recombinant Leishmania (Leishmania) infantum Ecto-Nucleoside Triphosphate Diphosphohydrolase NTPDase-2 as a new antigen in canine visceral leishmaniasis diagnosis

Acta Tropica ◽  
2013 ◽  
Vol 125 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Ronny Francisco de Souza ◽  
Yaro Luciolo dos Santos ◽  
Raphael de Souza Vasconcellos ◽  
Lucas Borges-Pereira ◽  
Ivo Santana Caldas ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Infantum ◽  
Nucleoside Triphosphate ◽  
Canine Visceral Leishmaniasis ◽  
Nucleoside Triphosphate Diphosphohydrolase

Leishmania infantum amastigote nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1): Its inhibition as a new insight into mode of action of pentamidine

2019 ◽  
Vol 200 ◽  
pp. 1-6 ◽  
Author(s):  
Ana Carolina Ribeiro Gomes Maia ◽  
Gabriane Nascimento Porcino ◽  
Michelle Lima Detoni ◽  
Leonardo Ramos Quellis ◽  
Nayara Braga Emídio ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Leishmania Infantum ◽  
Nucleoside Triphosphate ◽  
Nucleoside Triphosphate Diphosphohydrolase ◽  
Insight Into

scholarly journals Label-free assay based on immobilized capillary enzyme reactor of Leishmania infantum nucleoside triphosphate diphosphohydrolase ( Lic NTPDase-2-ICER-LC/UV)

2016 ◽  
Vol 1008 ◽  
pp. 98-107 ◽  
Author(s):  
Luana Magalhães ◽  
Arthur Henrique Cavalcante de Oliveira ◽  
Raphael de Souza Vasconcellos ◽  
Christiane Mariotini-Moura ◽  
Rafaela de Cássia Firmino ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Nucleoside Triphosphate ◽  
Label Free ◽  
Enzyme Reactor ◽  
Nucleoside Triphosphate Diphosphohydrolase

scholarly journals Performance of an indigenous β-mercaptoethanol-modified antigen in comparison with a commercial reference in direct agglutination test for detection of canine visceral leishmaniasis

2014 ◽  
Vol 63 (1) ◽  
pp. 106-110
Author(s):  
Saul José Semião-Santos ◽  
Laura Barral Veloso ◽  
Paulo Paes de Andrade ◽  
Marcia Almeida de Melo ◽  
Luis Miguel Lourenço Martins ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Infantum ◽  
Leishmania Donovani ◽  
Agglutination Test ◽  
Canine Visceral Leishmaniasis ◽  
Direct Agglutination Test ◽  
Serum Samples

We compared the performance of a locally produced β-mercaptoethanol-modified promastigote antigen (β-ME-Ag) of an indigenous Leishmania infantum strain against that of a trypsinized Leishmania donovani reference (REF-Ag) in the direct agglutination test (DAT) for detection of canine visceral leishmaniasis (CVL). One hundred and fifty-one serum samples collected from dogs belonging to four groups with different conditions were included. At a DAT titre of 1 : 320, statistically determined as optimal cut-off value for β-ME-Ag, and 1 : 160 for REF-Ag, a sensitivity and a specificity of 100 % were estimated for β-ME-Ag in comparison with 96.6 % and 100 %, respectively, for REF-Ag. Overall, levels of agglutination titres recorded for the two antigens were highly concordant (Cohen’s κ = 0.879) in both the CVL and non-CVL groups. Based on current results, and ease experienced in processing the antigen and reading the test outcome, we recommend incorporation of β-ME-Ag in DAT for confirmation or exclusion of suspected CVL in dogs.

scholarly journals High Performance of ELISA test using recombinant rLiNTPDase2 from Leishmania infantum: a Phase II diagnosis of Canine Visceral Leishmaniasis

Acta Tropica ◽  
2020 ◽  
Vol 209 ◽  
pp. 105535
Author(s):  
Anna Cláudia Alves de Souza ◽  
Raissa Barbosa de Castro ◽  
Yaro Luciolo dos Santos ◽  
Nancy da Rocha Torres Pavione ◽  
Joice de Melo Agripino ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Phase Ii ◽  
Leishmania Infantum ◽  
High Performance ◽  
Elisa Test ◽  
Canine Visceral Leishmaniasis

scholarly journals A multicentric evaluation of the recombinant Leishmania infantum antigen-based immunochromatographic assay for the serodiagnosis of canine visceral leishmaniasis

2014 ◽  
Vol 7 (1) ◽  
pp. 136 ◽  
Author(s):  
Deborah Bittencourt Fraga ◽  
Edimilson da Silva ◽  
Luciano Pacheco ◽  
Lairton Borja ◽  
Isaac de Oliveira ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Infantum ◽  
Immunochromatographic Assay ◽  
Canine Visceral Leishmaniasis

Canine visceral leishmaniasis caused by Leishmania infantum in Senegal: risk of emergence in humans?

2010 ◽  
Vol 12 (14-15) ◽  
pp. 1219-1225 ◽  
Author(s):  
B. Faye ◽  
A.L. Bañuls ◽  
B. Bucheton ◽  
M.M. Dione ◽  
O. Bassanganam ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Infantum ◽  
Canine Visceral Leishmaniasis
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