Bovine herpesvirus-1: Genetic diversity of field strains from cattle with respiratory disease, genital, fetal disease and systemic neonatal disease and their relationship to vaccine strains

2016 ◽  
Vol 223 ◽  
pp. 115-121 ◽  
Author(s):  
R.W. Fulton ◽  
J.M. d’Offay ◽  
E.J. Dubovi ◽  
R. Eberle
Keyword(s):  
Genetic Diversity ◽  
Respiratory Disease ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Neonatal Disease ◽  
Herpesvirus 1

Genetic diversity of 3′ region of glycoprotein D gene of bovine herpesvirus 1 and 5

Virus Genes ◽  
2014 ◽  
Vol 48 (3) ◽  
pp. 438-447 ◽  
Author(s):  
Carolina Kist Traesel ◽  
Mariana Sá e Silva ◽  
Marcelo Weiss ◽  
Fernando Rosado Spilki ◽  
Rudi Weiblen ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Bovine Herpesvirus ◽  
Glycoprotein D ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

scholarly journals Assessment of bovine respiratory disease progression in calves challenged with bovine herpesvirus 1 and Mannheimia haemolytica using point-of-care and laboratory-based blood leukocyte differential assays

2021 ◽  
Author(s):  
J Baruch ◽  
N Cernicchiaro ◽  
C A Cull ◽  
K F Lechtenberg ◽  
J S Nickell ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Point Of Care ◽  
Bovine Respiratory Disease ◽  
Bovine Herpesvirus ◽  
Mannheimia Haemolytica ◽  
Bovine Herpesvirus 1 ◽  
Lung Consolidation ◽  
Herpesvirus 1 ◽  
Cell Concentrations ◽  
Blood Leukocyte

Abstract Blood leukocyte differentials can be useful for understanding changes associated with bovine respiratory disease (BRD) progression. By improving turnaround time, point-of-care leukocyte differential assays (PCLD) may provide logistical advantages to laboratory-based assays. Our objective was to assess BRD progression in steers challenged with bovine herpesvirus 1 and Mannheimia haemolytica using point-of-care and laboratory-based blood leukocyte differentials. Thirty Holstein steers (average body weight of 211 kg + 2.4 kg) were inoculated intranasally on day 0 with bovine herpesvirus 1 and intrabronchially on day 6 with Mannheimia haemolytica. Blood leukocytes differentials were measured using both assays from study day 0 to 13. Linear mixed models were fitted to evaluate the associations between: 1) the type of assay (laboratory-based or PCLD) with respect to leukocyte, lymphocyte, and neutrophil concentrations, 2) study day with cell concentrations, and 3) cell concentrations with lung consolidation measured at necropsy. Point-of-care leukocyte, lymphocyte, and neutrophil concentrations were significantly associated (P < 0.05) with the respective cell concentrations obtained from the laboratory-based leukocyte differential. Cell concentrations reported by both assays differed significantly (P < 0.05) over time, indicating shifts from healthy to viral and bacterial disease states. Lymphocyte concentrations, lymphocyte / neutrophil ratios obtained from both assays, and band neutrophil concentrations from the laboratory-based assay were significantly associated (P < 0.05) with lung consolidation, enhancing assessments of disease severity. The PCLD may be a useful alternative to assess BRD progression when laboratory-based leukocyte differentials are impractical.

Inhibition of T-lymphocyte mitogenic responses and effects on cell functions by bovine herpesvirus 1.

1989 ◽  
Vol 63 (4) ◽  
pp. 1525-1530 ◽  
Author(s):  
J J Carter ◽  
A D Weinberg ◽  
A Pollard ◽  
R Reeves ◽  
J A Magnuson ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Cell Functions ◽  
Herpesvirus 1

scholarly journals Neutralizing Antibodies to Bovine Herpesvirus 1 in Reindeer

1982 ◽  
Vol 23 (4) ◽  
pp. 565-569
Author(s):  
C. Ek-Kommonen ◽  
P. Veijalainen ◽  
M. Rantala ◽  
E. Neuvonen
Keyword(s):  
Neutralizing Antibodies ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

scholarly journals Regulation of Krüppel-Like Factor 15 Expression by Herpes Simplex Virus Type 1 or Bovine Herpesvirus 1 Productive Infection

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1148
Author(s):  
Fouad S. El-mayet ◽  
Kelly S. Harrison ◽  
Clinton Jones
Keyword(s):  
Steady State ◽  
Promoter Activity ◽  
Bovine Herpesvirus ◽  
Productive Infection ◽  
Bovine Herpesvirus 1 ◽  
Protein Levels ◽  
Herpesvirus 1 ◽  
Simplex Virus ◽  
Hsv 1

Expression of Krüppel-like factor 15 (KLF15), a stress-induced transcription factor, is induced during bovine herpesvirus 1 (BoHV-1) reactivation from latency, and KLF15 stimulates BoHV-1 replication. Transient transfection studies revealed that KLF15 and glucocorticoid receptor (GR) cooperatively transactivate the BoHV-1-immediate-early transcription unit 1 (IEtu1), herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0), and ICP4 promoters. The IEtu1 promoter drives expression of bICP0 and bICP4, two key BoHV-1 transcriptional regulatory proteins. Based on these studies, we hypothesized infection is a stressful stimulus that increases KLF15 expression and enhances productive infection. New studies demonstrated that silencing KLF15 impaired HSV-1 productive infection, and KLF15 steady-state protein levels were increased at late stages of productive infection. KLF15 was primarily localized to the nucleus following infection of cultured cells with HSV-1, but not BoHV-1. When cells were transfected with a KLF15 promoter construct and then infected with HSV-1, promoter activity was significantly increased. The ICP0 gene, and to a lesser extent, bICP0 transactivated the KLF15 promoter in the absence of other viral proteins. In contrast, BoHV-1 or HSV-1 encoded VP16 had no effect on KLF15 promoter activity. Collectively, these studies revealed that HSV-1 and BoHV-1 productive infection increased KLF15 steady-state protein levels, which correlated with increased virus production.

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