High-Grade Gliomas Located in the Right Hemisphere Are Associated With Worse Quality of Life

Author(s):  
David Fortin ◽  
Christian Iorio-Morin ◽  
Anais Tellier ◽  
Philippe Goffaux ◽  
Maxime Descoteaux ◽  
...  
2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v190.4-v191
Author(s):  
Christian Iorio-Morin ◽  
Philippe Goffaux ◽  
Maxime Descoteau ◽  
Kevin Whittingstall ◽  
David Fortin

2014 ◽  
Vol 22 (5) ◽  
pp. 1349-1362 ◽  
Author(s):  
Kimberly R. Porter ◽  
Usha Menon ◽  
Nicholas A. Vick ◽  
John L. Villano ◽  
Michael L. Berbaum ◽  
...  

2008 ◽  
Vol 31 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Paul D. Brown ◽  
Paul A. Decker ◽  
Teresa A. Rummans ◽  
Matthew M. Clark ◽  
Marlene H. Frost ◽  
...  

Author(s):  
Amy D. Rodriguez

Abstract Purpose: This article introduces two types of prosody in human communication; describes right hemisphere contributions to prosody; describes prosodic deficits associated with right hemisphere damage; and discusses prevalence, quality of life, spontaneous recovery, and treatment of aprosodia. Method: Definitions of affective and linguistic prosody and aprosodia are provided. Results of lesion studies and neuroimaging studies are reviewed to inform the reader of the importance of the right hemisphere in prosody expression and comprehension, as well as to describe patterns of prosodic deficits in individuals with right hemisphere damage. Results and Conclusions: There is a large body of evidence supporting the role of the right hemisphere in affective prosody comprehension and production. Specifically, frontal brain regions and the basal ganglia are associated with aprosodia, suggesting there may be an underlying motor impairment. Because aprosodia is enduring and can impact quality of life, it is important to gain a better understanding of this disorder so that clinicians can accurately diagnose prosodic deficits and provide informed treatment.


2006 ◽  
Vol 38 (4) ◽  
pp. 212-220 ◽  
Author(s):  
Sherry Fox ◽  
Edward R. Laws ◽  
Frederick Anderson ◽  
Elana Farace

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 1524-1524
Author(s):  
P. D. Brown ◽  
K. V. Ballman ◽  
T. A. Rummans ◽  
M. J. Maurer ◽  
J. A. Sloan ◽  
...  

Author(s):  
C Iorio-Morin ◽  
P Goffaux ◽  
M Descoteau ◽  
K Whittingstall ◽  
D Fortin

Background: Because glioblastoma is currently incurable, the goal of therapy is the optimization of the patient’s quality of life (QOL). Tumor location is critical in screening surgical candidates, yet the impact of tumor location on QOL has never been demonstrated. By using a novel computer-driven algorithm, we set out to investigate the impact of tumor location on QOL. Methods: The tumors of fourty consecutive glioblastoma patients were segmented and the Euclidian distance between 90 brain regions and each tumor’s margin was calculated and correlated to the patients’ self-reported QOL as measured by the SNAS questionnaire. Results: QOL was statistically associated with proximity to three areas: the right para-hypocampal gyrus, the right posterior cingulate cortex and the right postcentral gyrus. We postulate that the adverse relation between proximity to these areas and QOL results from disruption in large-scale networks involved in high-order functions such as visuospatial memory. While harder to detect with a bedside clinical examination, such deficits are likely more impactful on QOL than those related to the motor cortex or Broca’s area. Conclusions: Tumor proximity to right parietooccipital region are associated with decreased QOL. This should be considered in the management strategies of glioma patients.


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