The MILC Study—Exploring the prevalence and outcomes associated with breast milk expression: A prospective cohort study

IntroductionThere is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether effects are only short term or persist long term remain uncertain.Methods and analysesIn this prospective cohort study, we will use metagenomic sequencing to determine: (1) the effect of intrapartum antibiotics on the composition of the breast milk, and the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (2) the effect of antibiotic exposure in the first year of life on the composition of the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (3) the effect of disruption of the infant oral and intestinal microbiome on health outcomes and (4) the compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome.Ethics and disseminationThe ABERRANT study has been approved by the commission cantonale d’éthique de la recherche sur l’être humain (CER-VD) du Canton de Vaud (#2019–01567). Outcomes will be disseminated through publication and will be presented at scientific conferences.Trial registration numberNCT04091282.

Download Full-text

Cross-sectional assessment of infants’ exposure to toxic metals through breast milk in a prospective cohort study of mining communities in Ghana

BMC Public Health ◽

10.1186/s12889-017-4403-8 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 10

Author(s):

David Kwaku Bansa ◽

Adolf Kofi Awua ◽

Rose Boatin ◽

Theodosia Adom ◽

Edward Christian Brown-Appiah ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Toxic Metals ◽

Prospective Cohort ◽

Cross Sectional ◽

Mining Communities

Download Full-text

Breast milk Vitamin B12 Concentration and Incidence of Diarrhea and Respiratory Infections among Infants in Urban Tanzania: a prospective cohort study

10.21203/rs.2.22305/v2 ◽

2020 ◽

Author(s):

Omar Ndano Lweno ◽

Christopher R Sudfeld ◽

Ellen Hertzmark ◽

Karim P Manji ◽

Anne Marie Darling ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Vitamin B12 ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Respiratory Infections ◽

Recent Trial ◽

Indian Children ◽

Childhood Infections ◽

Vitamin B12 Supplementation

Abstract Objective: A recent trial of vitamin B12 supplementation among Indian children 6-30 months found no effect on the incidence of diarrhea and respiratory infections. These results differ with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania. Results: A prospective cohort study was undertaken to determine the association of breast milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had breast milk vitamin B12 inadequacy (<310 pmol/L). Using generalized estimating equations, we found no overall association of milk vitamin B12 concentration with incident diarrhea and acute respiratory infections in infants. Studies measuring longitudinal changes of breast milk B12 concentration over time are needed to clarify the role of breast milk vitamin B12 in childhood infections.

Download Full-text

Breast Milk Parasite-Specific Antibodies and Protection From Amebiasis and Cryptosporidiosis in Bangladeshi Infants: A Prospective Cohort Study

Clinical Infectious Diseases ◽

10.1093/cid/cis1044 ◽

2012 ◽

Vol 56 (7) ◽

pp. 988-992 ◽

Cited By ~ 44

Author(s):

Poonum S. Korpe ◽

Yue Liu ◽

Abdullah Siddique ◽

Mamun Kabir ◽

Katherine Ralston ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Specific Antibodies

Download Full-text

Breast milk vitamin B12 concentration and incidence of diarrhea and respiratory infections among infants in urban Tanzania: a prospective cohort study

BMC Research Notes ◽

10.1186/s13104-020-05003-7 ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Omar N. Lweno ◽

Christopher R. Sudfeld ◽

Ellen Hertzmark ◽

Karim P. Manji ◽

Anne Marie Darling ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Vitamin B12 ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Respiratory Infections

Download Full-text

Common Breastfeeding Problems and Their Effect on The Continuation of Exclusive or Predominant Breastfeeding in Kinshasa

10.21203/rs.3.rs-36783/v1 ◽

2020 ◽

Author(s):

Pelagie Babakazo ◽

Marc Bosonkie ◽

Eric Mafuta ◽

Nono Mvuama ◽

Mala-Ali Mapatano

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Sociodemographic Characteristics ◽

Milk Supply ◽

Lactating Mothers ◽

Exclusive Or ◽

Breastfeeding Problems

Abstract Background: Breastfeeding has numerous advantages for infant, mother and society. However, many mothers discontinue breastfeeding due to problems they encounter. This study aimed to identify problems commonly experienced by breastfeeding mothers during the first six months in Kinshasa and to determine their effect on the continuation of exclusive or predominant breastfeeding.Methods: A prospective cohort study was carried out in Kinshasa from October 2012 to July 2013. A total of 422 mother-infant couples were recruited shortly after being discharged from twelve maternity facilities in Kinshasa and followed-up for six months. Interviews were conducted at the mother’s house during the first week after birth, and thereafter at monthly intervals for six months. Data included mother’s sociodemographic characteristics, the breastfeeding problems she experienced and information on child’s feeding. The Cox Proportional Model was used to determine the effect of breastfeeding problems on the continuation of exclusive or predominant breastfeeding.Results: Cracked or sore nipples, insufficient production of milk and breast engorgement were the most commonly experienced problems by lactating mothers. The problems occurred mainly during the first week (17.1%; CI95% 13.7–21.1) and the rest of the first month (16.2%; CI95% 12.8–20.3). Experiencing breastfeeding problems during any period negatively affected the continuation of exclusive or predominant breastfeeding.Conclusions: The first month after birth presents the most risk for the occurrence of breastfeeding problems. Those problems negatively affect the course of breastfeeding. Mothers should be supported as soon as possible after delivery, to improve their breastfeeding performance and to be informed on how to maintain breast milk supply.

Download Full-text

Breast milk Vitamin B12 Concentration and Incidence of Diarrhea and Respiratory Infections among Infants in Urban Tanzania: a prospective cohort study

10.21203/rs.2.22305/v1 ◽

2020 ◽

Author(s):

Omar Ndano Lweno ◽

Christopher R Sudfeld ◽

Ellen Hertzmark ◽

Karim P Manji ◽

Anne Marie Darling ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Vitamin B12 ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Respiratory Infections ◽

Childhood Infections ◽

Increased Risk ◽

Vitamin B12 Supplementation

Abstract Trials of vitamin B12 supplementation in children 6-30 months have shown an increased risk of diarrhea and respiratory infections among participants. These results are not consistent with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania. A prospective cohort study was undertaken to determine the association of milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had vitamin B12 concentrations less than the value used to define adequate intake (<310 pmol/L) in breast milk. Using generalized estimating equations, we found no overall association of milk vitamin B12 concentration with incident diarrhea and ARI in infants. Prospective studies that perform longitudinal evaluations of milk B12 concentration over time are needed to clarify the role of milk vitamin B12 in childhood infections.

Download Full-text

Determinants of Non-Exclusive Breastfeeding Practice During the First 6 Months After an Elective Caesarean Birth: A Prospective Cohort Study

10.21203/rs.3.rs-207813/v1 ◽

2021 ◽

Author(s):

Noraini Mohamad ◽

Norkhafizah Saddki ◽

Nazirah Johar ◽

Zaharah Sulaiman ◽

Tengku Alina Tengku Ismail

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Exclusive Breastfeeding ◽

Prospective Cohort ◽

Milk Supply ◽

Factors Associated ◽

Caesarean Birth ◽

Phone Calls ◽

Breastfeeding Practice

Abstract Background: Caesarean birth is associated with higher rate of non-exclusive breastfeeding (NEBF) than vaginal birth. NEBF refers to the provision of food or fluid besides breast milk, excluding drugs and vitamins, to infants before 6 months of age. This study determined the prevalence and factors associated with NEBF practice during the first 6 months after an elective caesarean birth.Methods: This prospective cohort study recruited 171 mothers who underwent an elective caesarean birth at two tertiary hospitals in Kelantan, Malaysia. Face-to-face interviews were conducted 2 days after the caesarean birth to obtain information on the variables of interest. Follow-up phone calls were made at 1, 3 and 6 months after birth to determine the prevalence of NEBF. Simple and multiple logistic regressions were used for data analysis.Results: The prevalence of NEBF was 19.9%, 40.4% and 57.9% at 1 month, 3 months and 6 months, respectively. Factors found to be associated with NEBF practice at 1 month were age of the last child, last child breastfeeding practice, and confidence with adequacy of breast milk. Last child breastfeeding practice was also found to be associated with NEBF practice at 3 months, as well as perception of insufficient of breast milk supply. At 6 months, perception of insufficient breast milk supply remains as one of factors associated with NEBF practice, together with experience of breast pain as baby suckled.Conclusion: The prevalence of NEBF increased as the child grew older. Perceived breast milk insufficiency was the only factor associated with NEBF at all months.

Download Full-text