Lymphatic endothelial cell fate specification in the mammalian embryo: An historical perspective

2021 ◽  
Author(s):  
Guillermo Oliver
Keyword(s):  
Endothelial Cell ◽  
Cell Fate ◽  
Historical Perspective ◽  
Lymphatic Endothelial Cell ◽  
Cell Fate Specification ◽  
Mammalian Embryo ◽  
Fate Specification

scholarly journals Lymphatic Endothelial Cell Plasticity in Development and Disease

Physiology ◽  
2017 ◽  
Vol 32 (6) ◽  
pp. 444-452 ◽  
Author(s):  
Wanshu Ma ◽  
Guillermo Oliver
Keyword(s):  
Cell Fate ◽  
Molecular Mechanisms ◽  
Immune Surveillance ◽  
Lymphatic Endothelial Cell ◽  
Lipid Absorption ◽  
Tissue Fluid ◽  
Mammalian Embryo ◽  
Fate Specification ◽  
Lymphatic Vasculature ◽  
Functional Features

The lymphatic vasculature is crucial for maintaining tissue-fluid homeostasis, providing immune surveillance and mediating lipid absorption. The lymphatic vasculature is tightly associated with the blood vasculature, although it exhibits distinct morphological and functional features. Endothelial cells (ECs) lineage fate specification is determined during embryonic development; however, accumulating evidence suggests that differentiated ECs exhibit remarkable heterogeneity and plasticity. In this review, we provide an overview of the molecular mechanisms promoting lymphatic cell fate specification in the mammalian embryo. We also summarize available data suggesting that lymphatic EC fate is reprogrammable in normal and pathological settings. We further discuss the possible advantages of cell fate manipulation to treat certain disorders associated with lymphatic dysfunction.

scholarly journals Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1

2017 ◽  
Vol 430 (1) ◽  
pp. 142-155 ◽  
Author(s):  
Kathleen Hübner ◽  
Kathrin S. Grassme ◽  
Jyoti Rao ◽  
Nina K. Wenke ◽  
Cordula L. Zimmer ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification

Sox proteins: regulators of cell fate specification and differentiation

Development ◽  
2013 ◽  
Vol 140 (20) ◽  
pp. 4129-4144 ◽  
Author(s):  
Y. Kamachi ◽  
H. Kondoh
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Sox Proteins

scholarly journals Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

2003 ◽  
Vol 259 (1) ◽  
pp. 150-161 ◽  
Author(s):  
Jun Motoyama ◽  
Ljiljana Milenkovic ◽  
Mizuho Iwama ◽  
Yayoi Shikata ◽  
Matthew P. Scott ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Cell Fate
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