Long Noncoding RNAs in Pluripotency of Stem Cells and Cell Fate Specification

2017 ◽  
pp. 223-252 ◽  
Author(s):  
Debosree Pal ◽  
M. R. S. Rao
Keyword(s):  
Stem Cells ◽  
Cell Fate ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals Monitoring the promoter activity of long noncoding RNAs and stem cell differentiation through knock-in of sgRNA flanked by tRNA in an intron

2021 ◽  
Author(s):  
Yu-Ting Zhao ◽  
Yangming Wang
Keyword(s):  
Stem Cells ◽  
Cell Fate ◽  
Promoter Activity ◽  
Embryonic Stem ◽  
Noncoding Rnas ◽  
Disease Status ◽  
Stem Cell Differentiation ◽  
Long Noncoding Rnas ◽  
Mammalian Genomes ◽  
Differentiation Status

Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that are often expressed in a tissue and cell specific manner. Therefore, a reporter that can faithfully reflect the expression or activity of lncRNAs can provide tools useful not only for uncovering the regulators of lncRNAs, but also for tracking cell fate and disease status. Here, we design a sgRNA precursor in an intron (GRIT) strategy that can monitor the promoter activity of lncRNAs. We used this strategy to report the expression of Lncenc1 and Neat1 in mouse embryonic stem cells (ESCs). Furthermore, we show that GRIT may be used to track differentiation status of stem cells. We anticipate that GRIT will be applicable in dissecting regulatory mechanisms underlying the transcription of lncRNAs, tracking cell fate switch during differentiation or disease progression and integrating the promoter activity of various RNAs for synthetic biology applications.

scholarly journals MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells

RSC Advances ◽  
2019 ◽  
Vol 9 (64) ◽  
pp. 37300-37311 ◽  
Author(s):  
Zixiang Wu ◽  
Shujing Liang ◽  
Wenyu Kuai ◽  
Lifang Hu ◽  
Airong Qian
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Fate ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
Recent Advances

The recent advances of miRNAs and lncRNAs in determining the cell fate of MSCs.

scholarly journals Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells

2011 ◽  
Vol 31 (23) ◽  
pp. 8351-8358 ◽  
Author(s):  
S.-J. Jeon ◽  
M. Fujioka ◽  
S.-C. Kim ◽  
A. S. B. Edge
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Inner Ear ◽  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms

2015 ◽  
Vol 17 (3) ◽  
pp. 300-315 ◽  
Author(s):  
Lluis Morey ◽  
Alexandra Santanach ◽  
Enrique Blanco ◽  
Luigi Aloia ◽  
Elphège P. Nora ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Embryonic Stem ◽  
Cell Fate Specification ◽  
Mesoderm Cell ◽  
Fate Specification

Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells

2018 ◽  
Vol 55 (9) ◽  
pp. 7107-7117 ◽  
Author(s):  
Raquel Coronel ◽  
Adela Bernabeu-Zornoza ◽  
Charlotte Palmer ◽  
Mar Muñiz-Moreno ◽  
Alberto Zambrano ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Precursor Protein ◽  
Cell Fate ◽  
Precursor Protein ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs

2015 ◽  
Vol 43 (5) ◽  
pp. 2638-2654 ◽  
Author(s):  
Sarah Nicklas ◽  
Satoshi Okawa ◽  
Anna-Lena Hillje ◽  
Laura González-Cano ◽  
Antonio del Sol ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cell Fate ◽  
Rna Helicase ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals Mammary gland development: cell fate specification, stem cells and the microenvironment

Development ◽  
2015 ◽  
Vol 142 (6) ◽  
pp. 1028-1042 ◽  
Author(s):  
J. L. Inman ◽  
C. Robertson ◽  
J. D. Mott ◽  
M. J. Bissell
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Cell Fate ◽  
Mammary Gland Development ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Gland Development
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