Clinical profile and comparison of scoring tools for the prediction of in-hospital mortality in convulsive status epilepticus in elderly

Background: The outcome of status epilepticus (SE) depends on various determinants such as age, type and duration of SE, etiology, management and associated comorbidities. This study was undertaken to describe the clinical profile and outcome of children with convulsive status epilepticus presenting to pediatric intensive care unit (PICU).Methods: Eighty-seven children between the age group 1 month to 12 years who at presentation or during the PICU stay had convulsive status epilepticus (CSE) were included in the study. Clinical profile, etiological spectrum and outcome at the end of hospital stay were analysed.Results: Median age of CSE was 4 years and 55 (63.2%) were below 5 years of age. Acute symptomatic etiology of CSE was a significant risk factor (p= 0.03) for refractory status epilepticus (RSE) which was seen in 31 patients (39%). Acute symptomatic etiology was the cause of CSE in 46 (59.2%) children. Remote symptomatic (26.4%), cryptogenic (18.4%) and progressive (2.3%) were other etiologies. Neuro-infection (29.8%) and febrile seizures (11.5%) were the most common acute symptomatic causes. Mortality and morbidity occurred in 23 (26.4%) and 8 (9.2%) patients respectively. Remaining 56 (64.6%) returned to baseline condition at the end of hospital stay. Longer duration (p= 0.03) and acute symptomatic etiology (p=0.049) were significant risk factors for mortality.Conclusions: Most common causes of CSE in children are acute symptomatic. Longer duration of status is associated with higher mortality. Hence, termination of seizure activity at the earliest, prudent management of respiratory or circulatory impairments in these children and improving the overall health care to prevent neuro-infections are important steps to improve outcome.

Download Full-text

Prediction of in-hospital mortality in status epilepticus: Evaluation of four scoring tools in younger and older adult patients

Epilepsy & Behavior ◽

10.1016/j.yebeh.2020.107572 ◽

2020 ◽

pp. 107572

Author(s):

Yan Jiang ◽

Min-Yan Cai ◽

Yi Yang ◽

Jun-Hong Geng ◽

Ying Zhang ◽

...

Keyword(s):

Status Epilepticus ◽

Hospital Mortality ◽

Older Adult ◽

Adult Patients ◽

Scoring Tools

Download Full-text

Convulsive status epilepticus due to different evolutionary stages of neurocysticercosis - solitary cyticercus granuloma, low cyst load, and single calcific lesion in an endemic country: Clinical profile

Seizure ◽

10.1016/j.seizure.2019.07.012 ◽

2019 ◽

Vol 71 ◽

pp. 229-232 ◽

Cited By ~ 1

Author(s):

Jagarlapudi M.K. Murthy ◽

Devdutt Suresh Deshmukh

Keyword(s):

Status Epilepticus ◽

Clinical Profile ◽

Convulsive Status Epilepticus ◽

Endemic Country

Download Full-text

Impact of co-morbidities on the mortality of patients with status epilepticus and the utility of RCBI score in evaluating the mortality of status epilepticus

10.21203/rs.2.20623/v1 ◽

2020 ◽

Author(s):

Yu Zhang ◽

Deng Chen ◽

Li-na Zhu ◽

ling liu

Keyword(s):

Status Epilepticus ◽

Hospital Mortality ◽

Roc Curve ◽

Poor Prognosis ◽

Influential Factors ◽

Western China ◽

Convulsive Status Epilepticus ◽

Roc Curve Analysis ◽

West China Hospital ◽

Area Under Roc Curve

Abstract Background: To investigate the influential factors of complications on prognosis of patients with status epilepticus, modify the Complication Burden Index （CBI）into the Rankin CBI（RCBI）, and analyze its practicability in status epilepticus in western China. Method: A total of 396 patients with status epilepticus were studied from December 2016 to January 2019 in West China Hospital. The clinical data were collected, including demographic characteristics, status epilepticus characteristics. Statistical analysis was performed using SPSS 22.0 and MedCalc ROC，and logistic regression was used to analyze the influencing factors of hospitalization death and poor prognosis (GOS scale is 1-3). Results: Of the 396 patients with status epilepticus included in the study, 43 (10.9%) died in hospital and 114 (28.8%) had poor prognosis. Using ROC curve analysis, when RCBI > 3, the area under the ROC curve of hospitalization death was 0.914 , p < 0.0001; When RCBI > 3, the area under ROC curve for poor prognosis was 0.882, p < 0.0001. There were 327 people with convulsive status epilepticus, including 41 deaths. When RCBI>3, the area under the hospital mortality curve was 0.915 (p<0.0001). A total of 100 patients had a poor prognosis. When RCBI>3, the area under the poor prognosis curve was 0.867 (p<0.0001). Conclusions: The hospital mortality rate of patients with status epilepticus is 10.9%. RCBI >3 points had a certain significance for predicting hospitalization death and poor prognosis of status epilepticus. There were no significant differences in RCBI scales for convulsive status epilepticus and non-convulsive status epilepticus.

Download Full-text

Clinical Profile, Aetiology, and Short Term Outcome of Convulsive Status Epilepticus in Children in Eastern India

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v5i1.109 ◽

2017 ◽

Vol 05 (01) ◽

pp. 15912-15916

Author(s):

Niloy Kumar Das ◽

Keyword(s):

Status Epilepticus ◽

Clinical Profile ◽

Convulsive Status Epilepticus ◽

Eastern India ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

Download Full-text

Improving the ability to predict hospital mortality among adults by combining two status epilepticus outcome scoring tools

Epilepsy & Behavior ◽

10.1016/j.yebeh.2020.107149 ◽

2020 ◽

Vol 110 ◽

pp. 107149 ◽

Cited By ~ 1

Author(s):

Yan Jiang ◽

Yi Yang ◽

Fei Feng ◽

Ying Zhang ◽

Xiao-Hang Wang ◽

...

Keyword(s):

Status Epilepticus ◽

Hospital Mortality ◽

Predict Hospital Mortality ◽

Scoring Tools

Download Full-text

CONVULSIVE STATUS EPILEPTICUS

The Professional Medical Journal ◽

10.29309/tpmj/2016.23.06.1603 ◽

2016 ◽

Vol 23 (06) ◽

pp. 660-664

Author(s):

Dileep Kumar ◽

Awais Bashir Larik ◽

Amir Shahzad

Keyword(s):

Status Epilepticus ◽

Hospital Mortality ◽

Statistical Significance ◽

Tertiary Care ◽

Care Facility ◽

Convulsive Status Epilepticus ◽

Inhospital Mortality ◽

Tertiary Care Facility ◽

History Of ◽

History Of Epilepsy

Objectives: To determine the in hospital mortality of convulsive status epilepticusin a tertiary care facility. Study Design: Cross sectional study. Place and Duration of Study:Neurology ward, Jinnah Postgraduate Medical Centre, Karachi, Medicine Department ofPeoples University Of Medical And Health Sciences Nawabshah from July 2015- Dec 2015.Material and Methods: All patients of either gender with age >15 years with status epilepticus,were included in the study. A detailed clinical history and relevant neurological examinationwas performed. All the patients who fulfill the inclusion criteria were enrolled in the study afterinformed written consent and explanation of the study protocol. All the information including inhospital mortality was entered on annexed proforma. All the patients were observed three to fivedays. Results: A total of 108 patients were included in this study fulfilling the inclusion criteria.The overall mean age of these patients was 31.3 ± 13.5 years. The age range of these patientswas 16 to 76 years. History of epilepsy was found in 106 (93.5%) of the patients, 88 (81.5%) ofthe patients had status epilepticus in past, 56 (51.9%) of the patients had drug withdrawal, 20(18.5%) of the patients had febrile illness and 2 (1.9%) of the patients had in hospital mortality.There was no statistical significance proportion difference was observed when comparedgender, history of epilepsy and status of epilepticus in past by in hospital mortality (p-values>0.05). Statistical significance proportion difference (p-value <0.05) was found in age and inhospital mortality. Conclusion: We recommend further studies to reach the firm conclusion.

Download Full-text