Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration

2004 ◽  
Vol 297 (1) ◽  
pp. 197-211 ◽  
Author(s):  
A.N Kalehua ◽  
J.E Nagel ◽  
L.M Whelchel ◽  
J.J Gides ◽  
R.S Pyle ◽  
...  
1999 ◽  
Vol 67 (10) ◽  
pp. 5480-5482 ◽  
Author(s):  
Pascale E. P. Dekkers ◽  
Marcel Levi ◽  
Sander J. H. van Deventer ◽  
Tom van der Poll

ABSTRACT A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1β (MIP-1β) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1β. Levels of MIP-1β and MCP-1 release were differentially regulated during endotoxemia.


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