scholarly journals Critical Role for Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α in Induction of Experimental Autoimmune Myocarditis and Effective Anti–Monocyte Chemoattractant Protein-1 Gene Therapy

Circulation ◽  
2005 ◽  
Vol 112 (22) ◽  
pp. 3400-3407 ◽  
Author(s):  
Stefan Göser ◽  
Renate Öttl; ◽  
Alexander Brodner ◽  
Thomas J. Dengler ◽  
Jan Torzewski ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Critical Role ◽  
Autoimmune Myocarditis ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Inflammatory Protein ◽  
Experimental Autoimmune Myocarditis ◽  
Macrophage Inflammatory Protein ◽  
Experimental Autoimmune

scholarly journals Divergent Roles of Tumor Necrosis Factor and Platelet-Activating Factor in Endotoxin-Induced Release of Monocyte Chemoattractant Protein 1 and Macrophage Inflammatory Protein 1β in Chimpanzees

1999 ◽  
Vol 67 (10) ◽  
pp. 5480-5482 ◽  
Author(s):  
Pascale E. P. Dekkers ◽  
Marcel Levi ◽  
Sander J. H. van Deventer ◽  
Tom van der Poll
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Platelet Activating Factor ◽  
Necrosis Factor Alpha ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein ◽  
Necrosis Factor

ABSTRACT A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1β (MIP-1β) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1β. Levels of MIP-1β and MCP-1 release were differentially regulated during endotoxemia.

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