Rates of molecular evolution vary in vertebrates for insulin-like growth factor-1 (IGF-1), a pleiotropic locus that regulates life history traits

2012 ◽  
Vol 178 (1) ◽  
pp. 164-173 ◽  
Author(s):  
Amanda M. Sparkman ◽  
Tonia S. Schwartz ◽  
Jill A. Madden ◽  
Scott E. Boyken ◽  
Neil B. Ford ◽  
...  
Keyword(s):  
Life History ◽  
Molecular Evolution ◽  
Growth Factor ◽  
Life History Traits ◽  
Insulin Like Growth Factor ◽  
Rates Of Molecular Evolution

scholarly journals Insulin-like growth factor-1 is associated with life-history variation across Mammalia

2014 ◽  
Vol 281 (1782) ◽  
pp. 20132458 ◽  
Author(s):  
Eli M. Swanson ◽  
Ben Dantzer
Keyword(s):  
Life History ◽  
Growth Factor ◽  
Life Histories ◽  
Life History Traits ◽  
Mammalian Species ◽  
Insulin Like Growth Factor ◽  
Life History Variation ◽  
Time Period ◽  
Path Analyses ◽  
Size Growth

Despite the diversity of mammalian life histories, persistent patterns of covariation have been identified, such as the ‘fast–slow’ axis of life-history covariation. Smaller species generally exhibit ‘faster’ life histories, developing and reproducing rapidly, but dying young. Hormonal mechanisms with pleiotropic effects may mediate such broad patterns of life-history variation. Insulin-like growth factor 1 (IGF-1) is one such mechanism because heightened IGF-1 activity is related to traits associated with faster life histories, such as increased growth and reproduction, but decreased lifespan. Using comparative methods, we show that among 41 mammalian species, increased plasma IGF-1 concentrations are associated with fast life histories and altricial reproductive patterns. Interspecific path analyses show that the effects of IGF-1 on these broad patterns of life-history variation are through its direct effects on some individual life-history traits (adult body size, growth rate, basal metabolic rate) and through its indirect effects on the remaining life-history traits. Our results suggest that the role of IGF-1 as a mechanism mediating life-history variation is conserved over the evolutionary time period defining mammalian diversification, that hormone–trait linkages can evolve as a unit, and that suites of life-history traits could be adjusted in response to selection through changes in plasma IGF-1.

scholarly journals Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals

Gene ◽  
2014 ◽  
Vol 549 (2) ◽  
pp. 228-236 ◽  
Author(s):  
Kalina T.J. Davies ◽  
Georgia Tsagkogeorga ◽  
Nigel C. Bennett ◽  
Liliana M. Dávalos ◽  
Christopher G. Faulkes ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Molecular Evolution ◽  
Growth Factor ◽  
Insulin Like Growth Factor

scholarly journals Exploring the mechanistic link between corticosterone and insulin-like growth factor-1 in a wild passerine bird

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5936 ◽  
Author(s):  
Zsófia Tóth ◽  
Jenny Q. Ouyang ◽  
Ádám Z. Lendvai
Keyword(s):  
Life History ◽  
Stress Response ◽  
Growth Factor ◽  
Physiological Stress ◽  
Passerine Bird ◽  
Insulin Like Growth Factor ◽  
Handling Stress ◽  
Trade Offs ◽  
Physiological Stress Response ◽  
Panurus Biarmicus

Background Physiological regulators of life history trade-offs need to be responsive to sudden changes of resource availability. When homeostasis is challenged by unpredictable stressors, vertebrates respond through a set of physiological reactions, which can promote organismal survival. Glucocorticoids have been traditionally recognized as one of the main regulators of the physiological stress response, but the role of an evolutionarily more conserved pathway, the hypothalamic-pituitary-somatotropic (HPS) axis producing insulin-like growth factor-1 (IGF-1) has received much less attention. Although IGF-1 is known to affect several life history traits, little is known about its role in the physiological stress response and it has never been studied directly in adult wild animals. Methods In this study, we combined field observations with a controlled experiment to investigate how circulating levels of IGF-1 change in response to stress and whether this change is due to concomitant change in glucocorticoids in a free-living songbird, the bearded reedling Panurus biarmicus. We used a standard capture-restraint protocol in field observation, in which we took first and second (stress induced: 15 minutes later) samples. In a follow-up experiment, we used a minimally invasive oral corticosterone manipulation. Results We showed that corticosterone levels significantly increased while IGF-1 levels significantly decreased during capture and handling stress. However, change in corticosterone levels were not related to change in IGF-1 levels. We found that experimentally elevated corticosterone levels did not affect IGF-1 levels. Discussion Our results are the first to highlight that circulating IGF-1 levels are responsive to stress independently from glucocorticoids and suggest that the HPS axis is an autonomous physiological pathway that may play an important role as regulator of life-history decisions.

scholarly journals Insulin-like growth factor 1 induces oxidative damage, but does not affect survival in a songbird

2020 ◽  
Author(s):  
Ádám Z. Lendvai ◽  
Zsófia Tóth ◽  
Janka Pénzes ◽  
Sarah Vogel-Kindgen ◽  
Bruno A. Gander ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Oxidative Damage ◽  
Natural Variation ◽  
Life History Traits ◽  
Insulin Like Growth Factor ◽  
Wild Animals ◽  
Elevated Plasma ◽  
Baseline Levels ◽  
Pre Treatment

AbstractLifespan evolves as a compromise between antagonistic selection forces. Insulin-like growth factor 1 (IGF-1) is a pleiotropic hormone that regulates several life-history traits. High levels of IGF-1 have been linked to increased mortality, partly by causing oxidative stress. However, these effects have no experimental evidence in wild animals. We implanted microspheres loaded with exogenous IGF-1 into bearded reedlings, a common short-lived Eurasian songbird. The treatment elevated plasma IGF-1 levels for at least 24 h. Oxidative damage to lipids significantly increased the day after the manipulation in treated birds, but returned to baseline levels four days post-treatment. The treatment had no effect on survival over 16 months; however, birds with higher pre-treatment (baseline) IGF-1 levels had better survival prospects. These results suggest that, although high IGF-1 levels may induce oxidative damage, natural variation in this hormone’s level may reflect the outcome of individual optimization.

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