High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae

2021 ◽  
Vol 66 ◽  
pp. 87-97
Author(s):  
Xiaodong Li ◽  
Yinmei Wang ◽  
Zhenjun Fan ◽  
Yan Wang ◽  
Pingping Wang ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Sustainable Production ◽  
Panax Species ◽  
Engineered Saccharomyces Cerevisiae ◽  
High Level

Sustainable production of glutathione from lignocellulose-derived sugars using engineered Saccharomyces cerevisiae

2018 ◽  
Vol 103 (3) ◽  
pp. 1243-1254 ◽  
Author(s):  
Jyumpei Kobayashi ◽  
Daisuke Sasaki ◽  
Takahiro Bamba ◽  
Tomohisa Hasunuma ◽  
Akihiko Kondo
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Sustainable Production ◽  
Engineered Saccharomyces Cerevisiae

scholarly journals Tempo and Mode of Ty Element Evolution in Saccharomyces cerevisiae

Genetics ◽  
1999 ◽  
Vol 151 (4) ◽  
pp. 1341-1351 ◽  
Author(s):  
I King Jordan ◽  
John F McDonald
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Negative Selection ◽  
Sequence Variation ◽  
Size Variation ◽  
Sequence Comparisons ◽  
Ty Elements ◽  
Ty Element ◽  
Amino Acid Sequence Variation ◽  
Element Evolution ◽  
High Level

Abstract The Saccharomyces cerevisiae genome contains five families of long terminal repeat (LTR) retrotransposons, Ty1–Ty5. The sequencing of the S. cerevisiae genome provides an unprecedented opportunity to examine the patterns of molecular variation existing among the entire genomic complement of Ty retrotransposons. We report the results of an analysis of the nucleotide and amino acid sequence variation within and between the five Ty element families of the S. cerevisiae genome. Our results indicate that individual Ty element families tend to be highly homogenous in both sequence and size variation. Comparisons of within-element 5′ and 3′ LTR sequences indicate that the vast majority of Ty elements have recently transposed. Furthermore, intrafamily Ty sequence comparisons reveal the action of negative selection on Ty element coding sequences. These results taken together suggest that there is a high level of genomic turnover of S. cerevisiae Ty elements, which is presumably in response to selective pressure to escape host-mediated repression and elimination mechanisms.

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