Molecular imaging of proliferation in vivo: Positron emission tomography with [18F]fluorothymidine

Methods ◽  
2009 ◽  
Vol 48 (2) ◽  
pp. 205-215 ◽  
Author(s):  
Andreas K. Buck ◽  
Ken Herrmann ◽  
Changxian Shen ◽  
Tobias Dechow ◽  
Markus Schwaiger ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Non-invasive imaging of high-risk coronary plaque: the role of computed tomography and positron emission tomography

2020 ◽  
Vol 93 (1113) ◽  
pp. 20190740 ◽  
Author(s):  
Rong Bing ◽  
Krithika Loganath ◽  
Philip Adamson ◽  
David Newby ◽  
Alastair Moss
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Coronary Plaque ◽  
Emission Tomography ◽  
Plaque Morphology ◽  
Biological Processes ◽  
Non Invasive ◽  
Positron Emission

Despite recent advances, cardiovascular disease remains the leading cause of death globally. As such, there is a need to optimise our current diagnostic and risk stratification pathways in order to better deliver individualised preventative therapies. Non-invasive imaging of coronary artery plaque can interrogate multiple aspects of coronary atherosclerotic disease, including plaque morphology, anatomy and flow. More recently, disease activity is being assessed to provide mechanistic insights into in vivo atherosclerosis biology. Molecular imaging using positron emission tomography is unique in this field, with the potential to identify specific biological processes using either bespoke or re-purposed radiotracers. This review provides an overview of non-invasive vulnerable plaque detection and molecular imaging of coronary atherosclerosis.

scholarly journals PET and the multitracer concept in the study of neurodegenerative diseases

2015 ◽  
Vol 9 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Henry Engler ◽  
Andres Damian ◽  
Cecilia Bentancourt
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Neurodegenerative Diseases ◽  
Brain Tissue ◽  
Neurodegenerative Disorders ◽  
Clinical Symptoms ◽  
Emission Tomography ◽  
Positron Emission ◽  
The Brain

ABSTRACT The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo,anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of 18F-flourodeoxyglucose (FDG) and N-[11C-methyl]-L-deuterodeprenyl (DED), FDG and N-[11C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[11C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [15O]H2O.

scholarly journals Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2

2019 ◽  
Author(s):  
Salvatore Bongarzone ◽  
nicola raucci ◽  
Igor Fontana ◽  
Federico Luzi ◽  
Antony Gee
Keyword(s):  
Carbon Dioxide ◽  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Rapid Method ◽  
Methyl Iodide ◽  
Emission Tomography ◽  
Positron Emission

A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [<sup>11</sup>C]carbon dioxide and [<sup>11</sup>C]methyl iodide into fluoride-activated silanes.

scholarly journals Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2

2019 ◽  
Author(s):  
Salvatore Bongarzone ◽  
nicola raucci ◽  
Igor Fontana ◽  
Federico Luzi ◽  
Antony Gee
Keyword(s):  
Carbon Dioxide ◽  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Rapid Method ◽  
Methyl Iodide ◽  
Emission Tomography ◽  
Positron Emission

A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating carbon-11 labelling precursors such as [<sup>11</sup>C]carbon dioxide and [<sup>11</sup>C]methyl iodide into fluoride-activated silanes.

Synthesis of11C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1and Its Prodrug Using Positron Emission Tomography

2015 ◽  
Vol 80 (12) ◽  
pp. 6250-6258 ◽  
Author(s):  
Hisashi Doi ◽  
Aya Mawatari ◽  
Masakatsu Kanazawa ◽  
Satoshi Nozaki ◽  
Yukihiro Nomura ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals In Vivo Molecular Imaging by Positron Emission Tomography (PET) and its Application to Drug Design and Diagnosis

2004 ◽  
Vol 44 (6) ◽  
pp. 265-270 ◽  
Author(s):  
Masaaki SUZUKI ◽  
Hisashi DOI ◽  
Takamitsu HOSOYA ◽  
Yasuyoshi WATANABE
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Drug Design ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals <sup>11</sup>C-Labeled Capsaicin and Its <i>in Vivo</i> Molecular Imaging in Rats by Positron Emission Tomography

2015 ◽  
Vol 06 (02) ◽  
pp. 216-220 ◽  
Author(s):  
Miki Goto ◽  
Hiroshi Mizuma ◽  
Yasuhiro Wada ◽  
Masaaki Suzuki ◽  
Yasuyoshi Watanabe ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals

2014 ◽  
Vol 3 (1) ◽  
pp. 6 ◽  
Author(s):  
Eduardo Zimmer ◽  
Antoine Leuzy ◽  
Venkat Bhat ◽  
Serge Gauthier ◽  
Pedro Rosa-Neto
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Emission Tomography ◽  
Small Animals ◽  
Tau Pathology ◽  
Positron Emission
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