In vivo genotoxicity study of single-wall carbon nanotubes using comet assay following intratracheal instillation in rats

2012 ◽  
Vol 64 (1) ◽  
pp. 124-129 ◽  
Author(s):  
Masato Naya ◽  
Norihiro Kobayashi ◽  
Shigehisa Endoh ◽  
Junko Maru ◽  
Kazumasa Honda ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Comet Assay ◽  
Intratracheal Instillation ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon

scholarly journals A 104-week pulmonary toxicity assessment of long and short single-wall carbon nanotubes after a single intratracheal instillation in rats

2017 ◽  
Vol 29 (11) ◽  
pp. 471-482 ◽  
Author(s):  
Kazumasa Honda ◽  
Masato Naya ◽  
Hiroshi Takehara ◽  
Hiromichi Kataura ◽  
Katsuhide Fujita ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Pulmonary Toxicity ◽  
Intratracheal Instillation ◽  
Toxicity Assessment ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon

scholarly journals Pulmonary and systemic responses of highly pure and well-dispersed single-wall carbon nanotubes after intratracheal instillation in rats

2011 ◽  
Vol 23 (13) ◽  
pp. 814-828 ◽  
Author(s):  
Norihiro Kobayashi ◽  
Masato Naya ◽  
Kohei Mizuno ◽  
Kazuhiro Yamamoto ◽  
Makoto Ema ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Intratracheal Instillation ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon ◽  
Systemic Responses

Single Wall Carbon Nanotubes in Rat Lung by Intratracheal Instillation

2012 ◽  
Vol 18 (S2) ◽  
pp. 1554-1555
Author(s):  
K. Yamamoto ◽  
T. Yoshida ◽  
R. Goto ◽  
A. Ogami ◽  
Y. Morimoto
Keyword(s):  
Carbon Nanotubes ◽  
Intratracheal Instillation ◽  
Single Wall Carbon Nanotubes ◽  
Rat Lung ◽  
Single Wall Carbon

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

scholarly journals Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model

2014 ◽  
pp. 4277 ◽  
Author(s):  
Antonio Barrientos-Duran ◽  
Ellen M. Carpenter ◽  
Nicole I. zur Nieden ◽  
Theodore I. Malinin ◽  
Juan Carlos Rodriguez-Manzaneque ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Tissue ◽  
Rat Model ◽  
Single Wall Carbon Nanotubes ◽  
Tissue Formation ◽  
Single Wall Carbon ◽  
Bone Tissue Formation

Non-invasive evaluation of cardiac repolarization in mice exposed to single-wall carbon nanotubes and ceria nanoparticles via intratracheal instillation

2016 ◽  
Vol 3 (3) ◽  
pp. 611-618 ◽  
Author(s):  
Karshak Kosaraju ◽  
Jarrett L. Lancaster ◽  
Stephen R. Meier ◽  
Steven Crawford ◽  
Steven Hurley ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Intratracheal Instillation ◽  
Single Wall Carbon Nanotubes ◽  
Cardiac Repolarization ◽  
Ceria Nanoparticles ◽  
Single Wall Carbon ◽  
Non Invasive ◽  
Novel Method ◽  
Invasive Evaluation

A novel method is proposed for non-invasive determination of cardiovascular toxicity due to ceria nanoparticles and single-wall carbon nanotubes from intratracheal instillation in mice.

Pulmonary Toxicity of Well-Dispersed Single-Wall Carbon Nanotubes Following Intratracheal Instillation

2012 ◽  
Vol 18-19 ◽  
pp. 9-25 ◽  
Author(s):  
Yasuo Morimoto ◽  
Masami Hirohashi ◽  
Masanori Horie ◽  
Akira Ogami ◽  
Takako Oyabu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Geometric Mean ◽  
Intratracheal Instillation ◽  
Neutrophil Infiltration ◽  
Lavage Fluid ◽  
Single Wall Carbon Nanotubes ◽  
Control Group ◽  
Distilled Water ◽  
Single Wall Carbon ◽  
Triton X

Single-Wall Carbon Nanotubes (SWCNTs) Were Well-Dispersed Using Ultrasonication to Conduct an Intratracheal Instillation Study. The Geometric Mean Diameter and Length of the SWCNT in Distilled Water Including 0.1 % Triton X-100 Was 44 Nm and 0.69 μm, Respectively. Rats Intratracheally Received 0.2 Mg or 0.4 Mg of SWCNT, and a Control Group Received Intratracheal Instillation of Distilled Water Containing 0.1 % Triton X-100 . The Rats Were then Sacrificed at 3 Days, 1 Week, 1 Month, 3 Months and 6 Months after Instillation. Bronchoalveolar Lavage Fluid (BALF) and Pathological Features Revealed that the Dose of SWCNT Induced Persistent Neutrophil Infiltration in Rat Lungs. In the Cytokine-Induced Neutrophil Chemoattractants (CINCs) Family, the Concentrations of CINC-1 and CINC-2 in the BALF Increased Persistently in the SWCNT-Exposed Groups. the Concentration of HO-1 in the BALF Was Also up-Regulated Persistently in the Exposed Groups. These Data Suggested that Well-Dispersed SWCNT Had an Inflammatory Potential in the Present Study.

Evaluation of the genotoxic potential of single-wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity assays

2011 ◽  
Vol 61 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Masato Naya ◽  
Norihiro Kobayashi ◽  
Kohei Mizuno ◽  
Kyomu Matsumoto ◽  
Makoto Ema ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon ◽  
Genotoxic Potential
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