Volume-rendered, three-dimensional echocardiographi determination of the size, shape, and position of atrial septal defects: Validation in an in vitro model

We introduce a microfluidic platform in which we culture three-dimensional skeletal muscle tissues, while evaluating tissue formation and toxin-induced muscle injury.

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52 An in vitro model for determination of the rate of resistance development in HIV

Antiviral Research ◽

10.1016/0166-3542(93)90430-q ◽

1993 ◽

Vol 20 ◽

pp. 68 ◽

Cited By ~ 2

Author(s):

L. Vrang ◽

C. Rydergȧrd ◽

C. Ȧhgren ◽

J. Wahlberg ◽

M. Uhlén ◽

...

Keyword(s):

In Vitro Model ◽

Resistance Development ◽

Vitro Model

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Determination of Functional ABCG2 Activity and Assessment of Drug–ABCG2 Interactions in Dairy Animals Using a Novel MDCKII In Vitro Model

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23399 ◽

2013 ◽

Vol 102 (2) ◽

pp. 772-784 ◽

Cited By ~ 16

Author(s):

Louise Wassermann ◽

Sandra Halwachs ◽

Stefan Lindner ◽

Kerstin U. Honscha ◽

Walther Honscha

Keyword(s):

In Vitro Model ◽

Dairy Animals ◽

Vitro Model

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Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime

Toxicology in Vitro ◽

10.1016/j.tiv.2014.10.003 ◽

2015 ◽

Vol 29 (1) ◽

pp. 162-167 ◽

Cited By ~ 5

Author(s):

Franz Worek ◽

Gabriele Horn ◽

Timo Wille ◽

Horst Thiermann

Keyword(s):

Real Time ◽

In Vitro Model ◽

Time Determination ◽

Vitro Model ◽

Butyrylcholinesterase Activity

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Clearance of Levofloxacin by an in Vitro Model of Continuous Venovenous Hemodialysis (CVVHD)

The International Journal of Artificial Organs ◽

10.1177/039139880703001005 ◽

2007 ◽

Vol 30 (10) ◽

pp. 889-895 ◽

Cited By ~ 2

Author(s):

S. Siewert ◽

B. Drewelow ◽

S.C. Mueller

Keyword(s):

In Vitro Model ◽

Urea Clearance ◽

Flow Rates ◽

Dialysate Flow ◽

Dialysate Flow Rate ◽

Continuous Venovenous Hemodialysis ◽

Vitro Model ◽

Positive Correlations

Information about the elimination and the adequate dosing of levofloxacin during renal replacement therapy is scarce. The aim of this study was to characterize in vitro the elimination of levofloxacin during continuous venovenous hemodialysis (CVVHD) and to investigate whether the CVVHD clearances of creatinine and urea are correlated with the levofloxacin clearance in order to facilitate dosage adjustments. An in vitro model of CVVHD was established using five dialyzer membranes at varying dialysate flow rates applied in the clinical setting (8, 16, 25, 33 and 41 ml/min). Plasma and dialysate samples were drawn for determination of levofloxacin, creatinine and urea concentrations to evaluate clearances by CVVHD. During CVVHD, the clearance of levofloxacin varied between 9.02 and 33.30 ml/min, depending on the chosen setup. Positive correlations (p<0.001) were received for: dialysate flow rate (QD) and creatinine/urea clearances (R>0.93); QD and levofloxacin clearance (R 0.59–0.71); levofloxacin and creatinine clearance (R 0.69–0.75); and levofloxacin and urea clearance (R 0.56–0.75) as well. When dosing critically ill patients, therefore, extracorporeal as well as total clearance of levofloxacin should be considered.

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