Association between heart rate–corrected QT interval and coronary risk factors in 2,894 healthy subjects (the DESIR study)

2000 ◽  
Vol 86 (5) ◽  
pp. 557-559 ◽  
Author(s):  
Laurent Fauchier ◽  
Pierre Maison-Blanche ◽  
Anne Forhan ◽  
Alain D’Hour ◽  
Patrick Lépinay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Qt Interval ◽  
Healthy Subjects ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
Corrected Qt Interval

Determinants of serum copper, zinc and selenium in healthy subjects

2005 ◽  
Vol 42 (5) ◽  
pp. 364-375 ◽  
Author(s):  
M Ghayour-Mobarhan ◽  
A Taylor ◽  
SA New ◽  
DJ Lamb ◽  
GAA Ferns
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Healthy Subjects ◽  
Serum Zinc ◽  
Serum Copper ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
Serum Concentrations ◽  
Lower Serum ◽  
Copper Zinc

Background: We have investigated the association between serum copper, zinc and selenium concentrations, dietary intake, and demographic characteristics, including individual coronary risk factors, in healthy subjects. Methods: Serum copper, zinc and selenium were measured by atomic absorption spectrometry in 189 healthy subjects. Serum glutathione peroxidase and caeruloplasmin were also determined for each subject. A previously validated food frequency questionnaire was used to estimate the dietary trace element intake. Results: Male subjects had significantly lower serum copper ( P<0.001) and caeruloplasmin ( P<0.001), and higher serum zinc ( P<0.05) and zinc:copper ratio ( P<0.001) than female subjects. Significant differences were observed in serum copper and caeruloplasmin concentrations ( P<0.01) with age. Weak but significant associations between dietary trace elements and their serum concentrations were observed for zinc ( r=0.18, P=0.02), copper ( r=0.17, P=0.03) and selenium ( r=0.19, P=0.02). Obese subjects had significantly lower serum concentrations of zinc ( P<0.05). In multifactorial analysis, dietary zinc ( P<0.05), serum high-density lipoprotein-cholesterol (HDL-C) ( P<0.05), diastolic blood pressure ( P<0.05) and age ( P=0.05) emerged as major predictors of serum zinc concentrations. The corresponding predictors for serum copper were C-reactive protein (CRP) ( P<0.001), serum HDL-C ( P<0.001), gender ( P=0.01), physical activity levels ( P<0.05) and dietary copper ( P<0.05). Serum selenium concentrations were predicted by serum total cholesterol ( P<0.01), serum CRP concentrations ( P<0.05) and dietary selenium ( P<0.03). Conclusion: Serum copper, zinc and selenium concentrations are influenced by physiological conditions such as age, diet and gender. Their serum concentrations are also associated with coronary risk factors, including body mass index, levels of physical activity, serum HDL-C and CRP.

scholarly journals Secondary risk factors of sudden cardiac death and genes of arterial hypertension

2020 ◽  
Vol 12 (3) ◽  
pp. 27-34
Author(s):  
Vasilii A. Kachnov ◽  
Vadim V. Tyrenko ◽  
Svetlana N. Kolyubaeva ◽  
Lilia A. Myakoshina ◽  
Alexandra S. Buntovskaya
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Sudden Cardiac Death ◽  
Arterial Hypertension ◽  
Qt Interval ◽  
Cardiac Death ◽  
Risk Variant ◽  
Corrected Qt Interval ◽  
Increased Risk ◽  
Heterozygous Variant

Purpose. To study the influence of polymorphisms of arterial hypertension genes and their various combinations on individual risk factors of sudden cardiac death. Materials and methods. 319 young people from 18 to 24 years of age who are entering military service by conscription were examined. The survey identified 69 individuals with signs of increased risk of sudden cardiac death after being examined for secondary risk factors of sudden cardiac death and taken a blood test to determine the polymorphisms of the genes AGT 521 CT, GNB3 825 CT, CYP11B2 344 CT, NOS3 786 TC. Results. The greatest influence on the severity of secondary risk factors was exerted by the following variants of a combination of gene polymorphisms: AGT 521 CT and NOS3 786 TC in the individuals with a heterozygous risk variant, both genes showed a significant increase in the duration of the corrected QT interval, heart rate, and a decrease in heart rate variability. AGT 521 CT and CYP11B2 344 CT homozygous risk variant of the CYP11B2 344 CT and the heterozygous risk variant AGT 521 CT is associated with a longer duration of the corrected QT interval, and the heterozygous risk variant for both genes is associated with higher heart rate values. AGT 521 CT and GNB3 825 CT combination of a homozygous risk variant of the gene GNB3 825 CT and the heterozygous variant of the gene AGT 521 CT is associated with the greatest effect on a heart rate. Conclusions. The presence of a homozygous risk variant of the gene NOS3 786 TC, a heterozygous risk variant of the gene GNB3 825 CT is prognostically unfavorable for its effect on the severity of secondary risk factors for sudden cardiac death. The combination of the heterozygous variant AGT 521 CT with a heterozygous variant of NOS3 786 TC and a homozygous risk variant by the gene CYP11B2 344 CT and the heterozygous risk variant AGT 521 CT are also the most unfavorable in terms of its effect on secondary risk factors for sudden cardiac death. Secondary risk factors of sudden cardiac death are influenced by both individual polymorphisms of genes of arterial hypertension, and their various combinations.

Electrocardiographic characteristics and associated outcomes in patients with Takotsubo syndrome. Insights from the RETAKO registry

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Martin-Demiguel ◽  
I Nunez-Gil ◽  
A Perez-Castellanos ◽  
O Vedia ◽  
A Uribarri ◽  
...  
Keyword(s):  
Heart Rate ◽  
Primary Endpoint ◽  
Qt Interval ◽  
Protective Factor ◽  
Independent Predictor ◽  
Prognostic Significance ◽  
Takotsubo Syndrome ◽  
St Segment Elevation ◽  
Corrected Qt Interval ◽  
St Segment

Abstract Background Our aim was to describe the prevalence and prognostic significance of electrocardiographic features in patients with Takotsubo syndrome (TTS). Methods Our data come from the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO). All patients with complete electrocardiogram were included. Results 246 patients were studied, mean age was 71.3±11.5 and 215 (87.4%) were women. ST-segment elevation was seen in 143 patients (59.1%) and was present in ≥2 wall leads in 97 (39.8%). Exclusive elevation in inferior leads was infrequent (5 - 2.0%). After 48 hours, 198 patients (88.0%) developed negative T-waves in a median of 8 leads with a mean amplitude of 0.7±0.5 mV. Mean corrected QT interval was 520±72 ms and it was independently associated with the primary endpoint of all-cause death and nonfatal cardiovascular events (p=0.002) and all-cause death (p=0.008). A higher heart rate at admission was also an independent predictor of the primary endpoint (p=0.001) and of developing acute pulmonary edema (p=0.04). ST-segment elevation with reciprocal depression was an independent predictor of all-cause death (p=0.04). Absence of ST-segment deviation was a protective factor (p=0.005) for the primary endpoint. Arrhythmias were independently associated with cardiogenic shock (p&lt;0.001). Conclusion Prolonged corrected QT interval, arrhythmia, heart rate at admission and broader repolarization alterations are associated with a poor outcome in TTS. Typical ECG at admission and after 48h. Funding Acknowledgement Type of funding source: None

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