Type 2 diabetes mellitus and colorectal cancer risk: a population-based, historical cohort study

2002 ◽  
Vol 97 (9) ◽  
pp. S121
Author(s):  
P LIMBURG
2006 ◽  
Vol 101 (8) ◽  
pp. 1872-1879 ◽  
Author(s):  
Paul J. Limburg ◽  
Robert A. Vierkant ◽  
Zachary S. Fredericksen ◽  
Cynthia L. Leibson ◽  
Robert A. Rizza ◽  
...  

2021 ◽  
Vol 160 (6) ◽  
pp. S-30
Author(s):  
Frederikke Sch⊘nfeldt Troelsen ◽  
Henrik Toft S⊘rensen ◽  
Lars Pedersen ◽  
Rune Erichsen

2019 ◽  
Vol 121 (10) ◽  
pp. 869-876 ◽  
Author(s):  
S. Ghazaleh Dashti ◽  
Wing Yan Li ◽  
Daniel D. Buchanan ◽  
Mark Clendenning ◽  
Christophe Rosty ◽  
...  

Abstract Background Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal cancer. Methods This study included 2023 (56.4% female) carriers with a mismatch repair gene mutation (737 in MLH1, 928 in MSH2, 230 in MSH6, 106 in PMS2, 22 in EPCAM) recruited by the Colon Cancer Family Registry between 1998 and 2012. Weighted Cox regression was used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the associations between self-reported type 2 diabetes, high cholesterol, triglyceride and colorectal cancer risk. Results  Overall, 802 carriers were diagnosed with colorectal cancer at a median age of 42 years. A higher risk of colorectal cancer was observed in those with self-reported type-2 diabetes (HR 1.92; 95% CI, 1.03–3.58) and high cholesterol (HR 1.76; CI 1.23–2.52) compared with those without these conditions. There was no evidence of high triglyceride being associated with colorectal cancer risk. Conclusion For people with Lynch syndrome, self-reported type-2 diabetes mellitus and high cholesterol were associated with increased colorectal cancer risk.


PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123279 ◽  
Author(s):  
Ding-Cheng Chan ◽  
Rong-Sen Yang ◽  
Chung-Han Ho ◽  
Yau-Sheng Tsai ◽  
Jhi-Joung Wang ◽  
...  

2015 ◽  
Vol 42 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Chin-Wang Hsu ◽  
Chin-Sheng Lin ◽  
Sy-Jou Chen ◽  
Shih-Hua Lin ◽  
Cheng-Li Lin ◽  
...  

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