Hepatocyte growth factor in gingival crevicular fluid and the distribution of hepatocyte growth factor-activator in gingival tissue from adult periodontitis

2002 ◽  
Vol 47 (9) ◽  
pp. 655-663 ◽  
Author(s):  
K Kakimoto ◽  
M Machigashira ◽  
T Ohnishi ◽  
T Kajihara ◽  
I Semba ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Gingival Crevicular Fluid ◽  
Gingival Tissue ◽  
Hepatocyte Growth Factor Activator ◽  
Crevicular Fluid ◽  
Hepatocyte Growth

scholarly journals Hepatocyte Growth Factor Levels in the Saliva and Gingival Crevicular Fluid in Smokers with Periodontitis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Sukumaran Anil ◽  
Sajith Vellappally ◽  
R. S. Preethanath ◽  
Sameer A. Mokeem ◽  
Hani S. AlMoharib ◽  
...  
Keyword(s):  
Growth Factor ◽  
Periodontal Disease ◽  
Hepatocyte Growth Factor ◽  
Gingival Crevicular Fluid ◽  
Control Group ◽  
Inflammatory Conditions ◽  
Healthy Control ◽  
Never Smokers ◽  
Crevicular Fluid ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF) production by oral fibroblasts is enhanced by various molecules that are induced during inflammatory conditions including periodontitis. HGF plays an important role in the progression of periodontitis, by stimulating intense growth of epithelial cells and preventing regeneration of connective tissue attachments. Smokers have a greater risk factor in the pathogenesis and progression of periodontal disease. The objective of the study was to estimate the level of HGF in saliva and gingival crevicular fluid (GCF) in smokers with periodontitis and to compare these levels with that of nonsmokers with periodontitis and healthy controls. The HGF levels were found to be significantly high in the saliva and GCF of smokers with periodontitis compared to both never-smokers with periodontitis and the healthy control group. The elevated levels of HGF in the saliva and GCF in the study population could explain the intrinsic mechanism triggering the severity of the periodontitis in smokers. Further studies are necessary to validate the current observations and to establish a sensitive marker to predict periodontal disease activity.

scholarly journals Activation of the zymogen of hepatocyte growth factor activator by thrombin.

1993 ◽  
Vol 268 (30) ◽  
pp. 22927-22932
Author(s):  
T Shimomura ◽  
J Kondo ◽  
M Ochiai ◽  
D Naka ◽  
K Miyazawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth Factor Activator ◽  
Hepatocyte Growth
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