Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase

2002 ◽  
Vol 63 (11) ◽  
pp. 1997-2000 ◽  
Author(s):  
Javier Garcı́a-Villafranca ◽  
José Castro
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Hepatic Fatty Acid

scholarly journals ETV5 regulates hepatic fatty acid metabolism through PPAR signaling pathway

2020 ◽  
Author(s):  
Ada Admin ◽  
Zhuo Mao ◽  
Mingji Feng ◽  
Zhuoran Li ◽  
Minsi Zhou ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Association Studies ◽  
Sequencing Analysis ◽  
Dependent Manner ◽  
Alcoholic Fatty Liver ◽  
Hepatic Fatty Acid ◽  
Ppar Signaling

ETV5 is an ETS transcription factor which has been associated with obesity in genomic association studies. However, little is known about the role of ETV5 in hepatic lipid metabolism and non-alcoholic fatty liver disease (NAFLD). In the present study, we found that ETV5 protein expression was increased in diet- and genetic-induced steatotic liver. ETV5 responded to the nutrient status in an mTORC1 dependent manner and in turn regulated mTORC1 activity. Both viral-mediated and genetic depletion of ETV5 in mice led to increased lipid accumulation in the liver. RNA sequencing analysis revealed that PPAR signaling and fatty acid degradation/metabolism pathways were significantly downregulated in ETV5 deficient hepatocytes <i>in vivo</i> and <i>in vitro. </i>Mechanistically, ETV5 could bind to the PPRE region of PPAR downstream genes and enhance its transactivity. Collectively, our study identifies ETV5 as a novel transcription factor for the regulation of hepatic fatty acid metabolism which is required for the optimal β oxidation process. ETV5 may provide a therapeutic target for the treatment of hepatic steatosis.<br>

scholarly journals Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hua Yang ◽  
Fei Wang ◽  
Xinya Guo ◽  
Feng Liu ◽  
Zhonghua Liu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Therapeutic Strategy ◽  
Acid Metabolism ◽  
Latent Tuberculosis ◽  
Host Immunity ◽  
Acetyl Coa ◽  
Nutrient Sources ◽  
Mycobacterial Genome ◽  
Mycobacterial Protein

AbstractPathogenic mycobacteria induce the formation of hypoxic granulomas during latent tuberculosis (TB) infection, in which the immune system contains, but fails to eliminate the mycobacteria. Fatty acid metabolism-related genes are relatively overrepresented in the mycobacterial genome and mycobacteria favor host-derived fatty acids as nutrient sources. However, whether and how mycobacteria modulate host fatty acid metabolism to drive granuloma progression remains unknown. Here, we report that mycobacteria under hypoxia markedly secrete the protein Rv0859/MMAR_4677 (Fatty-acid degradation A, FadA), which is also enriched in tuberculous granulomas. FadA acts as an acetyltransferase that converts host acetyl-CoA to acetoacetyl-CoA. The reduced acetyl-CoA level suppresses H3K9Ac-mediated expression of the host proinflammatory cytokine Il6, thus promoting granuloma progression. Moreover, supplementation of acetate increases the level of acetyl-CoA and inhibits the formation of granulomas. Our findings suggest an unexpected mechanism of a hypoxia-induced mycobacterial protein suppressing host immunity via modulation of host fatty acid metabolism and raise the possibility of a novel therapeutic strategy for TB infection.

Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats

2012 ◽  
Vol 52 (3) ◽  
pp. 1015-1027 ◽  
Author(s):  
Takashi Ide ◽  
Ayana Azechi ◽  
Sayaka Kitade ◽  
Yoko Kunimatsu ◽  
Natsuko Suzuki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Lipoic Acid ◽  
Acid Metabolism ◽  
Combined Effect ◽  
Hepatic Fatty Acid

scholarly journals Maternal obesity or weight loss around conception impacts hepatic fatty acid metabolism in the offspring

Obesity ◽  
2014 ◽  
Vol 22 (7) ◽  
pp. 1685-1693 ◽  
Author(s):  
Lisa M. Nicholas ◽  
Leewen Rattanatray ◽  
Janna L. Morrison ◽  
David O. Kleemann ◽  
Simon K. Walker ◽  
...  
Keyword(s):  
Weight Loss ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Maternal Obesity ◽  
Acid Metabolism ◽  
Hepatic Fatty Acid

Hepatic Fatty Acid Metabolism as a Determinant of Plasma and Liver Triacylglycerol Levels. Studies on Tetradecylthioacetic and Tetradecylthiopropionic Acids

1995 ◽  
Vol 227 (3) ◽  
pp. 715-722 ◽  
Author(s):  
Daniel K. Asiedu ◽  
Ayman Al-Shurbaji ◽  
Arild C. Rustan ◽  
Ingemar Bjorkhem ◽  
Lars Berglund ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Hepatic Fatty Acid

Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats

2011 ◽  
Vol 1811 (7-8) ◽  
pp. 441-451 ◽  
Author(s):  
Jolita Ciapaite ◽  
Nicole M. van den Broek ◽  
Heleen te Brinke ◽  
Klaas Nicolay ◽  
Jeroen A. Jeneson ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
High Fat Diet ◽  
Acid Metabolism ◽  
High Fat ◽  
Differential Effects ◽  
Hepatic Fatty Acid ◽  
Short And Long Term
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